A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles [PDF]
Beilstein Journal of Organic Chemistry, 2019 A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles.
Alexei Lukin +4 more
doaj +2 more sources
Molecules, 2012 A series of 2,4-diaryl-5(4H)-imidazolones were prepared and evaluated for their anti-inflammatory activities. Some selected 2,4-diaryl-5(4H)-imidazolones exhibited excellent anti-inflammatory activity in the carrageenan-induced rat paw edema model ...
Abdel-Ghany H. El-Helby +4 more
doaj +2 more sources
Synthesis of Phthalyl Substituted Imidazolones and Schiff Bases as Antimicrobial Agents [PDF]
E-Journal of Chemistry, 2011 A new series of phthalyl substituted imidazolones (4a–g) and Schiff bases (5a–d) were synthesized from 2-methyl-(m-nitro-1,3-dioxo-1,3-dihydro-(2H)-isoindole-2-yl)-5-amino-1,3,4-thiadiazole (3a–b).
Pramilla Sah, Neha Saraswat, Manu Manu
doaj +2 more sources
Synthesis of some New Imidazolones and 1,2,4-Triazoles Bearing Benzo[b]thiophene Nucleus as Antimicrobial Agents [PDF]
Journal of Sciences, Islamic Republic of Iran, 2005 2-Phenyl-1-(3?,5?-dichloro-2?-benzo(b)thiophenoylamino)-4-arylidine-5-imidazolones (2a-j) were prepared from the 2-hydrazinocarbonyl-3,5-dichlorobenzo[b]thiophene 1 by the reaction with different oxazolinone which were prepared by the condensation of ...
doaj +2 more sources
Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]
ChemistryThis review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc +2 more sources
Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N-Functionalization of Heterocycles and Late-Stage Modifications. [PDF]
Angew Chem Int Ed EnglN‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Ospina F +10 more
europepmc +3 more sources
Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles
Molecules, 2021 A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones
Maksim Kukushkin +10 more
doaj +1 more source
Chemistry Proceedings, 2023 In this study, we investigated the conformational abilities of n,n’-(Alkanediyl)-bis(2-phenyl-3,5-dihydro-4H-imidazol-4-one)s (1) to gain insight into their biological potential as a platform for the generation of various QACs. Among the conformers of 1,
Anastasia A. Lobankova +2 more
doaj +1 more source
Synthesis of 2-Imidazolones and 2-Iminoimidazoles [PDF]
Organic Letters, 2011 Convenient methods for the direct conversion of imidazolium salts to the corresponding 2-imidazolone or 2-imino imidazole derivatives have been developed. Treatment of the salt with commercial bleach leads to effective oxidation at C2 and the formation of the corresponding imidazolone. Alternatively, treatment of the salt with an N-chloro amide affords
Heather M, Lima, Carl J, Lovely
openaire +2 more sources
Heterogeneous Pd-Catalyzed Efficient Synthesis of Imidazolones via Dehydrogenative Condensation between Ureas and 1,2-Diols [PDF]
, 2022 A heterogeneously catalyzed protocol for the acceptorless dehydrogenative condensation between N,N′-disubstituted ureas and 1,2-diols to afford imidazolones was developed.
Juan Camilo Arango-Daza (5884058) +4 more
core +2 more sources