Results 1 to 10 of about 392 (91)

In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition [PDF]

Scientific Reports
This work investigates the anti-trypanosomal activities of ten thiohydantoin derivatives against the parasite Trypanosoma cruzi. Compounds with aliphatic chains (THD1, THD3, and THD5) exhibited the most promising IC50 against the epimastigote form of T ...
Priscila Goes Camargo, Helena Tiemi Suzukawa, Patrícia Morais Lopes Pereira, Mariana Luiza Silva, Fernando Macedo Jr, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Sueli Fumie Yamada-Ogatta, Camilo Henrique da Silva Lima, Marcelle de Lima Ferreira Bispo   +9 more
doaj   +2 more sources

Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]

Molecules
Hydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede, Eo-Jin Park, Om Darlami, Dongyun Shin   +3 more
doaj   +2 more sources

Exploration of newly synthesized azo-thiohydantoins as the potential alkaline phosphatase inhibitors via advanced biochemical characterization and molecular modeling approaches [PDF]

BMC Chemistry
In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, elemental and HRMS analysis. The compounds were evaluated for alkaline phosphatase activity
Hafiz Muhammad Attaullah, Syeda Abida Ejaz, Pervaiz Ali Channar, Aamer Saeed, Rabail Ujan, Seema Zargar, Sajid Ali Channar, Reshma Sahito, Tanveer A. Wani, Qamar Abbas   +9 more
doaj   +2 more sources

Synthesis of thiourea derivatives bearing the benzo[b]thiophene nucleus as potential antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2005
The synthesis of a group of thiohydantoins and thiobarbiturates derived from 2-N-arylthiopyridocarbonyl-3,5-dichlorobenzo[b]thiophene is described. The structures of the new compounds are supported by IR, 1H-NMR and mass spectral data.
Thakar K.M., Paghdar D.J., Chovatia P.T., Joshi H.S.   +3 more
doaj   +3 more sources

Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)

Molecules, 2021
Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds.
Ranran Zhang, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, Minghua Qiu   +5 more
doaj   +1 more source

Synthesis, characterization and cytotoxicity of palladium(II) complex of 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one [PDF]

Journal of the Serbian Chemical Society, 2013
The polydentate ligand, 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one, was synthesized by intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethylchloroacetate.
Šmit Biljana, Pavlović Radoslav Z., Radosavljević-Mihailović Ana, Došen Anja, Ćurčić Milena G., Šeklić Dragana S., Živanović Marko N.   +6 more
doaj   +1 more source

Heterocyclic systems containing S/N regioselective nucleophilic competition: Facile synthesis, antitubercular and antimicrobial activity of thiohydantoins and iminothiazolidinones containing the benzo [PDF]

Journal of the Serbian Chemical Society, 2005
The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)-thioureas 1a-k were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated with chloroacetic acid, yielded ...
Kachhadia V.V., Patel M.R., Joshi H.S.
doaj   +1 more source

Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)

Natural Products and Bioprospecting, 2018
Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before.
Yan-Jie Huang, Xing-Rong Peng, Ming-Hua Qiu   +2 more
doaj   +1 more source

Convenient Synthesis of 2-Thioimidazolone/Menadione Conjugates via a Two-Step Sequence Starting with Direct Amination of Menadione

SynOpen, 2020
A convenient route to conjugates of 2-thiohydantoins and menadione with linkers of various chemical nature through a two-stage reaction sequence (direct amination of the menadione with a functional amine followed by modification of a functional group) is
Dmitry A. Guk, Olga O. Krasnovskaya, Nikolai V. Zyk, Elena K. Beloglazkina   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity

Molecules, 2023
Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine.
Yan A. Ivanenkov, Maxim E. Kukushkin, Anastasia A. Beloglazkina, Radik R. Shafikov, Alexander A. Barashkin, Andrey A. Ayginin, Marina S. Serebryakova, Alexander G. Majouga, Dmitry A. Skvortsov, Viktor A. Tafeenko, Elena K. Beloglazkina   +10 more
doaj   +1 more source