A Simple Synthesis of 2-Thiohydantoins [PDF]
Molecules, 2006 2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Yulu Zhang +2 more
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In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition [PDF]
Scientific ReportsThis work investigates the anti-trypanosomal activities of ten thiohydantoin derivatives against the parasite Trypanosoma cruzi. Compounds with aliphatic chains (THD1, THD3, and THD5) exhibited the most promising IC50 against the epimastigote form of T ...
Priscila Goes Camargo +9 more
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Exploration of newly synthesized azo-thiohydantoins as the potential alkaline phosphatase inhibitors via advanced biochemical characterization and molecular modeling approaches [PDF]
BMC ChemistryIn the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, elemental and HRMS analysis. The compounds were evaluated for alkaline phosphatase activity
Hafiz Muhammad Attaullah +9 more
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Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]
MoleculesHydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede +3 more
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Synthesis of thiourea derivatives bearing the benzo[b]thiophene nucleus as potential antimicrobial agents [PDF]
Journal of the Serbian Chemical Society, 2005 The synthesis of a group of thiohydantoins and thiobarbiturates derived from 2-N-arylthiopyridocarbonyl-3,5-dichlorobenzo[b]thiophene is described. The structures of the new compounds are supported by IR, 1H-NMR and mass spectral data.
Thakar K.M. +3 more
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Molecules, 2021 Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds.
Ranran Zhang +5 more
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Synthesis, characterization and cytotoxicity of palladium(II) complex of 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one [PDF]
Journal of the Serbian Chemical Society, 2013 The polydentate ligand, 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one, was synthesized by intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethylchloroacetate.
Šmit Biljana +6 more
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ANTITHYROID ACTIVITY OF THIOHYDANTOINS [PDF]
British Journal of Pharmacology and Chemotherapy, 1958 The antithyroid activity of 2‐thiohydantoin and some derivatives has been measured in rats, after a single dose and, also, after daily administration for 6 weeks. 2‐Thiohydantoin and its 5‐alkyl derivatives from 5‐methyl to 5‐sec‐butyl‐ showed considerable antithyroid activity at a dose of 0.05 m.mole/kg.
R, KILPATRICK, D T, ELMORE, D R, WOOD
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Fluorous Synthesis of Hydantoins and Thiohydantoins. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Wei, Zhang, Yimin, Lu
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Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)
Natural Products and Bioprospecting, 2018 Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before.
Yan-Jie Huang +2 more
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