Molecules, 2018 The preparation of 5-methylene-thiohydantoins using solid-phase synthesis is reported in this paper. After sulfonylation of immobilized Ser (t-Bu)-OH with 4-nitrobenzenesulfonyl chloride followed by alkylation with various bromoketones, the 4-Nos group ...
Petra Králová +3 more
doaj +2 more sources
Molecules, 1999 The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alkyl ...
Martin Kovac +2 more
doaj +2 more sources
Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)
Natural Products and Bioprospecting, 2018 Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before.
Yan-Jie Huang +2 more
doaj +2 more sources
Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea [PDF]
Beilstein Journal of Organic Chemistry, 2019 A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev +5 more
doaj +2 more sources
Heterocyclic systems containing S/N regioselective nucleophilic competition: facile synthesis, antitubercular and antimicrobial activity of thiohydantoins and iminothiazolidinones containing the benzo[b]thiophene moiety [PDF]
Journal of the Serbian Chemical Society, 2005 The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)thioureas 1ak were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated with chloroacetic acid, yielded ...
H. S. JOSHI +2 more
doaj +1 more source
Acta Chimica SlovenicaThis study investigates a series of zingerone 2-thiohydantoins for anticancer activity towards human breast adenocarcinoma and explores possible mechanisms of anticancer action.
Petar Stanić +6 more
doaj +2 more sources
[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones. [PDF]
Int J Mol Sci, 2023 Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and 1,3-dienes (cyclopentadiene, cyclohexadiene, 2,3-dimethylbutadiene, isoprene).
Shybanov DE +8 more
europepmc +2 more sources
Kinetics and mechanism of racemisation reactions of configurationally labile stereogenic centres in drug-like molecules in aqueous solutions; thiohydantoins and related compounds [PDF]
In this thesis, studies of the kinetic and mechanism of racemisation of several drug-like molecule have been presented. Chapter 1 provides background information on the general mechanisms of racemisation of drugs in general, and hydantoin derivatives. In
Ahmad, Hiwa Omer
core +6 more sources
Fluorous Synthesis of Hydantoins and Thiohydantoins. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Wei, Zhang, Yimin, Lu
openaire +2 more sources
Angewandte Chemie, Volume 134, Issue 11, March 7, 2022., 2022 A prebiotic synthesis of the nucleobase orotate, and the citric acid cycle intermediate pyruvate, proceeds in a single pot from two small glycine derivatives, hydantoin and glyoxylate, under mild aqueous conditions. These findings support a co‐evolution of pathways to core protometabolites and nucleic acid building blocks in a common environment ...
Alyssa P. Clay +5 more
wiley +2 more sources