Results 41 to 50 of about 465 (157)

1,2‐Diaza‐1,3‐Dienes as a Multifaceted Synthons for the Synthesis of Heterocycles: A Fifteen‐Years Update

open access: yesEuropean Journal of Organic Chemistry, Volume 27, Issue 44, November 25, 2024.
1,2‐Diaza‐1,3‐butadienes, also called azoalkenes, have received considerable attention as key synthons for constructing various heterocyclic scaffolds. This minireview summarizes the contribution of our group in this field over the period from 2009 to the present, focusing on the role of the azoene building block in forming the heterocyclic structures.
Lucia De Crescentini   +4 more
wiley   +1 more source

HYDANTOINS: SYNTHESIS OF 5-THIOHYDANTOINS. [NINETEENTH PAPER.] [PDF]

open access: yesJournal of the American Chemical Society, 1912
n ...
Johnson, Treat B., Chernoff, Lewis H.
openaire   +2 more sources

Chiral Quaternary Ammonium Salt‐Catalyzed Enantioselective Addition Reactions of Hydantoins

open access: yesHelvetica Chimica Acta, Volume 107, Issue 3, March 2024.
Abstract We herein report a protocol for the asymmetric 1,4‐addition of hydantoins to various Michael acceptors by utilizing Cinchona alkaloid‐based chiral quaternary ammonium salt catalysts. Various products were obtained with moderate to good enantioselectivities and accompanying computational investigations helped to identify key interactions ...
Katharina Röser   +5 more
wiley   +1 more source

Dopaminergic neuronal death via necroptosis in Parkinson's disease: A review of the literature

open access: yesEuropean Journal of Neuroscience, Volume 59, Issue 6, Page 1079-1098, March 2024.
We reviewed the current literature on the potential role of necroptosis, a recently characterized regulated cell death mechanism, in Parkinson's disease (PD) pathogenesis. We summarized findings from studies on necroptosis in PD preclinical models and PD human tissue samples, discussing how manipulating necroptosis might open a novel therapeutic ...
Maria Regoni   +2 more
wiley   +1 more source

Necrostatin‐1 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes

open access: yesJournal of Biomedical Materials Research Part A, Volume 112, Issue 2, Page 288-295, February 2024.
Abstract Immunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in the absence of immunosuppression but graft survival time is still limited. This limited graft survival is caused by a combination of tissue responses to the encapsulating biomaterial and islets. A significant loss of islet cells occurs in the immediate
Alexandra M. Smink   +4 more
wiley   +1 more source

A comparison of the exposure system of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts

open access: yesFood Science &Nutrition, Volume 12, Issue 1, Page 471-480, January 2024.
The exposure systems of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts diHOPrVal were compared. DiHOPrVal formation was observed using several chemicals other than glycidol with different behaviors in vitro and in vivo. However, in both cases, the amount of diHOPrVal produced was very small compared with glycidol. This study
Yuko Shimamura   +4 more
wiley   +1 more source

Exploring zingerone 2-thiohydantoins as anticancer agents against breast adenocarcinoma: Cytotoxicity, HSA and DNA binding, molecular docking and ADMET prediction

open access: yesActa Chimica Slovenica
This study investigates a series of zingerone 2-thiohydantoins for anticancer activity towards human breast adenocarcinoma and explores possible mechanisms of anticancer action.
Petar Stanić   +6 more
doaj   +1 more source

Enobosarm in Muscle Wasting

open access: yes
JCSM Communications, Volume 9, Issue 1, January/June 2026.
Stephan von Haehling
wiley   +1 more source

Studies in the Synthesis of Thiohydantoins: Part II. Derivatives of 3-(Benzothiazole-2-YL) Thiohydantoins

open access: yes, 1975
Department of Chemistry, Sambalpur University, Sambalpur and Department of Chemistry, G. M. College, Sambalpur. Manuscript received 27 May 1972; accepted 4 July 1975. Several substituted benzothiazolyl thiohydantoias (I), their arylideae derivatives (II) and dibromo compounds (W) have been synthesised.
M. BEHERA, P. N. DHAL, A. NAYAK
openaire   +2 more sources

A FLUORIMETRIC ASSAY FOR MINUTE AMOUNTS OF SOME THIOHYDANTOINS

open access: yesJournal of Pharmacy and Pharmacology, 1958
Abstract A fluorimetric assay sensitive to μg. quantities of certain thiohydantoins has been devised using dichloroquinone chloroimide as a fluorescence reagent. The nature of the buffer used is critical. Satisfactory results have been obtained for recoveries from urine, spinal fluid and plasma.
M E, AUERBACH, E, ANGELL
openaire   +2 more sources

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