Results 21 to 30 of about 697 (188)
ANTITHYROID ACTIVITY OF THIOHYDANTOINS [PDF]
British Journal of Pharmacology and Chemotherapy, 1958 The antithyroid activity of 2‐thiohydantoin and some derivatives has been measured in rats, after a single dose and, also, after daily administration for 6 weeks. 2‐Thiohydantoin and its 5‐alkyl derivatives from 5‐methyl to 5‐sec‐butyl‐ showed considerable antithyroid activity at a dose of 0.05 m.mole/kg.
R, KILPATRICK, D T, ELMORE, D R, WOOD
openaire +2 more sources
Fluorous Synthesis of Hydantoins and Thiohydantoins. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Wei, Zhang, Yimin, Lu
openaire +2 more sources
Angewandte Chemie, Volume 134, Issue 11, March 7, 2022., 2022 A prebiotic synthesis of the nucleobase orotate, and the citric acid cycle intermediate pyruvate, proceeds in a single pot from two small glycine derivatives, hydantoin and glyoxylate, under mild aqueous conditions. These findings support a co‐evolution of pathways to core protometabolites and nucleic acid building blocks in a common environment ...
Alyssa P. Clay +5 more
wiley +2 more sources
The Chemical Record, Volume 23, Issue 11, November 2023., 2023 Efforst are described for developing Brønsted base‐catalyzed, site‐ and stereoselective α‐functionalization of a variety of unsaturated enolizable carbonyl compounds via transient enolates featuring an extended π‐system. Abstract Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis.
Mikel Oiarbide, Claudio Palomo
wiley +1 more source
European Journal of Organic Chemistry, Volume 2022, Issue 40, October 26, 2022., 2022 A new strategy has been proposed for the synthesis of an array of imidazo[5,1‐c][1,4]oxazine chemotypes by using a planned aza‐Michael addition in a 3‐CR heteroring‐forming, post‐cyclization transformation followed by an intramolecular fused‐heterocycles formation process.
Giacomo Mari +4 more
wiley +1 more source
A recent update on new synthetic chiral compounds with antileishmanial activity
Chirality, Volume 34, Issue 10, Page 1279-1297, October 2022., 2022 ∎ Abstract Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and ...
Michele Verboni +2 more
wiley +1 more source
Archiv der Pharmazie, Volume 355, Issue 5, May 2022., 2022 Structurally distinct enzalutamide‐based proteolysis‐targeting chimeras (PROTACs) were designed, synthesized, and biochemically analyzed. For the first time, androgen receptor degraders were evaluated in lung cancer cells, where significant degradation of the target was observed.
Lukas M. Gockel +8 more
wiley +1 more source
Aldol Reactions of Conformationally Stable Axially Chiral Thiohydantoin Derivatives. [PDF]
ACS Omega, 2021 Two novel axially chiral ortho-trifluoromethylphenyl thiohydantoin derivatives have been prepared atroposelectively from the reaction of R and S alanine methyl ester HCl salts with ortho-trifluoromethylphenyl isothiocyanate in the presence of triethyl ...
Sarigul Ozbek S, Bacak Erdik M, Dogan I.
europepmc +2 more sources
European Journal of Organic Chemistry, Volume 2021, Issue 41, Page 5649-5660, November 8, 2021., 2021 Intramolecularly hydrogen‐bonded analogues of the green fluorescence protein chromophore with an aminoimidazole moiety were synthesised and characterised. The fluorescence mechanism and substituent effects were investigated in a combined experimental‐computational approach, and a 279‐fold improvement in the quantum yield was realised.
Ervin Kovács +7 more
wiley +1 more source