Results 181 to 190 of about 62,607,340 (217)
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24R,25-Dihydroxyvitamin D3 increases bone mass in vivo
Osteoporosis International, 1993Reviewing the results obtained in this series of experiments we can conclude firstly that 24R,25(OH)2D3 is able to increase bone volume when administered exogenously. This action in increasing the bone volume in normal vitamin-D-replete animals may represent the anabolic action of the vitamin D-endocrine system on bone in vivo.
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Biological evaluation of epoxy analogs of 1α,25-dihydroxyvitamin D3
Steroids, 1995The biological activity of 16-epoxy side-chain analogs of 1 alpha,25-dihydroxyvitamin D3, (1 alpha,25(OH)2D3) was evaluated in vitro and in vivo. Compared to 1 alpha,25(0H)2D3, all analogs had lower affinities for the pig duodenal vitamin D receptor and also for the human serum vitamin D binding protein.
K, Allewaert +7 more
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1α,25-dihydroxyvitamin D3 corrects osteomalacia in hypoparathyroidism and pseudohypoparathyroidism
Acta Endocrinologica, 1983Abstract. Deficiency of circulating 1α,25-dihydroxyvitamin D (1α,25(OH)2D) regularly occurs in hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP). Osteomalacia is occasionally found in the two diseases. Two patients, one with HP and the other with PHP, both with symptomatic and biopsy-proven osteomalacia, were studied before and after treatment
S, Epstein +4 more
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Excretion of metabolites of 1α,25-dihydroxyvitamin D3 in rat bile
Archives of Biochemistry and Biophysics, 1980Abstract Bile is the major excretory route for 1,25-dihydroxyvitamin D3 and its metabolites. The amount of radioactivity as a percentage of the total dose found in either urine or combined feces and intestinal contents of bile duct-cannulated rats does not vary with the dose of 1α,25-dihydroxy-[3α-3H]vitamin D3 whereas the percentage of the dose ...
B L, Onisko +3 more
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1980
The secosteroid vitamin D plays an essential role in calcium (Ca) and phosphorus (Pi) homeostasis and serves as a precursor of a minimum of eight hydroxylated metabolites1. Of these the two dihydroxylated derivatives produced by the kidney, particularly 1α, 25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 24R,25-dihydroxyvitamin D3 [24,25(OH)2 D3] appear to ...
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The secosteroid vitamin D plays an essential role in calcium (Ca) and phosphorus (Pi) homeostasis and serves as a precursor of a minimum of eight hydroxylated metabolites1. Of these the two dihydroxylated derivatives produced by the kidney, particularly 1α, 25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 24R,25-dihydroxyvitamin D3 [24,25(OH)2 D3] appear to ...
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Endocrine, 2001
Recent studies indicate that 1alpha,25-dihydroxyvitamin D3 (1alpha,25[OH]2D3) and 24R,25-dihydroxyvitamim D3 (24R,25[OH]2D3) differentially regulate proliferation, differentiation, and matrix synthesis of growth plate chondrocytes. To determine whether both metabolites play the same or different roles in vivo, we used the vitamin D-deficient rat as a ...
D D, Dean +6 more
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Recent studies indicate that 1alpha,25-dihydroxyvitamin D3 (1alpha,25[OH]2D3) and 24R,25-dihydroxyvitamim D3 (24R,25[OH]2D3) differentially regulate proliferation, differentiation, and matrix synthesis of growth plate chondrocytes. To determine whether both metabolites play the same or different roles in vivo, we used the vitamin D-deficient rat as a ...
D D, Dean +6 more
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Evidence for Disordered Control of 1,25-Dihydroxyvitamin D Production in Absorptive Hypercalciuria
New England Journal of Medicine, 1984Karl Insogna +2 more
exaly
Low 1,25-Dihydroxyvitamin D in Heparin-Induced Osteopenia.
Lancet, The, 1980D Aarskog, Lage Aksnes, Dagfinn Aarskog
exaly