Results 101 to 110 of about 51,947 (207)

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Characterization of the 26S proteasome network in Plasmodium falciparum

, 2015
In eukaryotic cells, the ubiquitin-proteasome system as a key regulator of protein quality control is an excellent drug target. We therefore aimed to analyze the 26S proteasome complex in the malaria parasite Plasmodium falciparum, which still threatens ...
Prieto, J., Yates, J., Delahunty, C., Fritz-Wolf, K., Rahlfs, S., Becker, K., Wang, L.   +6 more
core   +1 more source

26S proteasome regulates the degradation of microtubule

四川大学学报. 自然科学版, 2019
To analyze the degradation mechanism of microtubules protein in the plant cell, we used anti-MT, proteasome inhibitor MG132 combining the in vivo and in vitro techniques of genetics and plant molecular biology to reveal that the degradation of TUA and ...
PAN Ting, YANG Mu-Tong, LIU Yang-Xuan, SUN Xiu-Qiang, TU Sheng-Bin, JAN Smalle, WANG Song-Hu   +6 more
doaj  

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Proteasome dynamics in response to metabolic changes

Frontiers in Cell and Developmental Biology
Proteasomes, essential protease complexes in protein homeostasis, adapt to metabolic changes through intracellular movements. As the executive arm of the ubiquitin-proteasome system, they selectively degrade poly-ubiquitinated proteins in an ATP ...
Cordula Enenkel, Oliver P. Ernst, Oliver P. Ernst   +2 more
doaj   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Biochemical characterization of IDE-26S proteasome interaction.

, 2015
The chymotriptic-like (A), tryptic-like (B) and caspase-like (C) activities of a highly purified 26S proteasome were assayed on specific fluorogenic substrates in presence of highly purified eukaryotic IDE. The reported values represent the ratio between
Francesca Sciandra (606570), Umberto Tarantino (772007), Stefano Marini (173645), Magda Gioia (605480), Diego Sbardella (173620), Massimo Coletta (175517), Grazia Raffaella Tundo (772006), Chiara Ciaccio (173617), Andrea Brancaccio (75133), Manuela Bozzi (606571)   +9 more
core   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Parkin Directly Modulates 26S Proteasome Activity

, 2010
Parkinson's disease (PD) is a common neurodegenerative disease that involves the deterioration of dopaminergic neurons in the substantia nigra pars compacta.
Boram Min, Eunju Im, Lang Yoo, Christine Stichel-Gunkel, Jong Bok Yoon, Hyun Jung Lee, Jiho Yoo, Hermann Lübbert, Kwang Chul Chung, Ji Won Um, Hyun-Soo Cho   +10 more
core   +1 more source