Results 91 to 100 of about 51,947 (207)

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Disease-associated prion protein oligomers inhibit the 26S proteasome [PDF]

, 2007
* Kristiansen, M., Deriziotis, P. These authors contributed equally to this work.* - The mechanism of cell death in prion disease is unknown but is associated with the production of a misfolded conformer of the prion protein.
Deriziotis, P., Ovaa, H., Naumann, H., Portis, JL, Jackson, G., Kristiansen, M, Deriziotis, P, Clarke, AR, Menéndez-Benito, V, Dantuma, NP, Collinge, J., van Leeuwen, FWB, Tabrizi, S., van, Leeuwen FWB, Dimcheff, D., van Leeuwen, F., Dimcheff, DE, Ovaa, H, Collinge, J, Portis, J., Jackson, GS, Kristiansen, M., Dantuma, N., Menéndez-Benito, V., Tabrizi, SJ, Naumann, H, Clarke, A.   +26 more
core   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

A kinetic model for USP14 regulated substrate degradation in 26S proteasome.

PLoS Computational Biology
Despite high-resolution structural studies on the USP14-proteasome-substrate complexes, time-resolved cryo-electron microscopy (cryo-EM) results on USP14-regulated allostery of the 26S proteasome are still very limited and a quantitative understanding of
Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao   +3 more
doaj   +1 more source

The 26S Proteasome and Initiation of Gene Transcription

Biomolecules, 2014
Transcription activation is the foremost step of gene expression and is modulated by various factors that act in synergy. Misregulation of this process and its associated factors has severe effects and hence requires strong regulatory control.
Geetha Durairaj, Peter Kaiser
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Emodin potentiates the antiproliferative effect of interferon alpha/beta by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

, 2016
The 26S proteasome is a negative regulator of type I interferon (IFN-alpha/beta) signaling. Inhibition of the 26S proteasome by small molecules may be a new strategy to enhance the efficacy of type I IFNs and reduce their side effects.
He, YJ, Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Peoples R China., Wang, F (reprint author), Chinese Acad Sci, Sichuan Translat Med Res Hosp, Chengdu, Peoples R China., Shen, XF, Wang, P, Yang, LJ, Liu, WL, Li, S, Huang, JM, Wang, F, Suksamrarn, A, Zhang, GL   +11 more
core  

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome (Version v1)

Computational raw data of the paper "Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome".Peer ...
Coll-Martínez, Bernat, Gallisà-Suñé, Núria, Bujons, Jordi, González-Artero, Alba, Carneros, Héctor, Roda, Tania, Casasampere, Mireia, Fabriàs, Gemma, Zuin, Alice, Crosas, Bernat, Delgado, Antonio, Casas, Josefina, Abad, José Luis, Fernández-Nogueira, Patricia, Alqahtani, Abdulateef   +14 more
core   +1 more source