Results 81 to 90 of about 51,947 (207)

Proteins interacting with the 26S proteasome.

, 2004
Udgivelsesdato: 2004-JulThe 26S proteasome is the multi-protein protease that recognizes and degrades ubiquitinylated substrates targeted for destruction by the ubiquitin pathway.
Gordon, C, Hartmann-Petersen, R
core   +1 more source

Research and Therapeutic Advances of 26S Proteasome Subunit 
in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer
Lung cancer is one of the most common cancers worldwide and is the leading cause of cancer deaths. Lung adenocarcinoma is the most common type of lung cancer.
Chenrui MOU, Shaotong ZOU, Chao REN, Zihan YI, Jianlin SHI   +4 more
doaj   +1 more source

Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity.

PLoS Pathogens, 2018
Regulated degradation of proteins by the 26S proteasome plays important roles in maintenance and signalling in eukaryotic cells. Proteins are marked for degradation by the action of E3 ligases that site-specifically modify their substrates by adding ...
James J Furniss, Heather Grey, Zhishuo Wang, Mika Nomoto, Lorna Jackson, Yasuomi Tada, Steven H Spoel   +6 more
doaj   +1 more source

Important roles of C-terminal residues in degradation of capsid protein of classical swine fever virus

Virology Journal, 2019
Background Capsid (C) protein plays an important role in the replication of classical swine fever virus (CSFV). The ubiquitin proteasome system (UPS) involves in replication of many viruses via modulation of viral proteins.
Yuming Chen, Erpeng Zhu, Shuangqi Fan, Hongxing Ding, Shengming Ma, Mengjiao Zhu, Shaofeng Deng, Jinding Chen, Mingqiu Zhao   +8 more
doaj   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Observation of an unstained 26S proteasome.

, 2012
(A) Image of an unstained human erythrocyte 26S proteasome obtained by our method using FE-SEM. The image conditions are as follows: accelerating voltage 3.6-kV EB, application of a 2D Gaussian filter (size 9×9 pixels, σ = 2).
Toshihiko Ogura (131016)
core   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression [PDF]

, 2019
Dependence on the 26S proteasome is an Achilles' heel for triple-negative breast cancer (TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib, successfully targets MM but often leads to drug-resistant disease relapse and ...
Dixon, Jack E., Banerjee, Sourav, Chavez, Lukas, Sah, Robert L., Juarez, Edwin F., Wiley, Sandra E, Dixon, Jack E, Chapman, Owen, Mesirov, Jill P., Liang, Ruqi, Gutierrez, Haydee L., Wiley, Sandra E., Cooper, Kimberly L., Wei, Tiantian, Juarez, Edwin F, Mesirov, Jill P, Wang, Jue, Lei, Xiaoguang, de la Vega, Laureano, Mayfield, Joshua E, Xiao, Junyu, Sah, Robert L, Banerjee, Sourav; id_orcid, Cooper, Kimberly L, Lee, Jenna J, Costello, Caitlin, Mayfield, Joshua E., Tandon, Vasudha, de la Vega, Laureano; id_orcid, Lee, Jenna J., Gutierrez, Haydee L   +30 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

Nature Communications, 2017
The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long ...
David Haselbach, Jil Schrader, Felix Lambrecht, Fabian Henneberg, Ashwin Chari, Holger Stark   +5 more
doaj   +1 more source