Results 131 to 140 of about 27,758 (248)

Identification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry. [PDF]

J Biol Chem
MacRae NS, Dong KC, Harimoto H, Martin A.   +3 more
europepmc   +1 more source

Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity. [PDF]

Biomolecules, 2023
Steinberger S, Adler J, Shaul Y.
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome. [PDF]

Nat Commun
Casasampere M, Carneros H, Roda T, Zuin A, Gallisà-Suñé N, González-Artero A, Coll-Martínez B, Abad JL, Alqahtani A, Casas J, Fernández-Nogueira P, Delgado A, Bujons J, Fabriàs G, Crosas B.   +14 more
europepmc   +1 more source

The Exploitation of Host 26S Proteasome as a New Stratedy for Bacterial Pathogenicity. [PDF]

Front Plant Sci, 2022
Wang C, Zeng L.
europepmc   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

P53: Stability from the Ubiquitin-Proteasome System and Specific 26S Proteasome Inhibitors. [PDF]

ACS Omega, 2022
do Patrocinio AB, Rodrigues V, Guidi Magalhães L.   +2 more
europepmc   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

The ubiquitin-26S proteasome system and autophagy relay proteome homeostasis regulation during silique development. [PDF]

Plant J, 2022
Yu P, Hua Z.
europepmc   +1 more source