Results 151 to 160 of about 27,758 (248)

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome. [PDF]

Nat Struct Mol Biol
Arkinson C, Dong KC, Gee CL, Costello SM, Soe AC, Hura GL, Marqusee S, Martin A.   +7 more
europepmc   +1 more source

Simulating the directional translocation of a substrate by the AAA+ motor in the 26S proteasome. [PDF]

Proc Natl Acad Sci U S A, 2021
Saha A, Warshel A.
europepmc   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Activators of the 26S proteasome when protein degradation increases. [PDF]

Exp Mol Med
Lee D.
europepmc   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome. [PDF]

Cell Rep
Htet ZM, Dong KC, Martin A.
europepmc   +1 more source

Developing a Bimolecular Affinity Purification Strategy to Isolate 26S Proteasome Holocomplexes for Complex-Centric Proteomic Analysis. [PDF]

Anal Chem, 2021
Yu C, Wang X, Li W, Liu Y, Huang L.
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Oxidative and salt stresses alter the 26S proteasome holoenzyme and associated protein profiles in Arabidopsis thaliana. [PDF]

BMC Plant Biol, 2021
Bonea D, Noureddine J, Gazzarrini S, Zhao R.   +3 more
europepmc   +1 more source