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The Effects Of 27-Hydroxycholesterol And Palmitic Acid On Parkinson's Disease-Like Pathology

, 2018
Jared Schommer
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Pathophysiological role of 27-hydroxycholesterol in human diseases

Advances in Biological Regulation, 2022
Oxysterols are oxygenated cholesterol derivatives and important regulators of cholesterol metabolism, lipid homeostasis, the immune system, and membrane fluidity regulation. Although the detailed mechanism of action of oxysterols remains unclear, activation of some nuclear receptors, such as liver X receptor α (LXRα) and RAR-related orphan receptors ...
Dayea Kim, Kwang Min Lee, Chanhee Lee, Yeon Suk Jo, Muradillaeva Shakhnoza Muradillaevna, Jae Ho Kim, Jong Hyuk Yoon, Parkyong Song   +7 more
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Oxysterols: 27-hydroxycholesterol and its radiolabeled analog

Steroids, 2000
We describe a convenient and stereoselective route to the synthesis of 27-hydroxycholesterol. Also its radiolabeled analog, 22, 23 di [(3)H]-27-hydroxycholesterol with high specific radioactivity (55 Ci/mmol) was synthesized by this method. Julia condensation of steroidal 22-sulfone with aldehyde, led to the addition of the 23-27 carbon side chain ...
T E, D'Ambra, N B, Javitt, J, Lacy, P, Srinivasan, T, Warchol   +4 more
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27‐Hydroxycholesterol enhanced osteoclastogenesis in lung adenocarcinoma microenvironment

Journal of Cellular Physiology, 2018
Abstract27‐Hydroxycholesterol (27‐HC) has been implicated in the pathological process of estrogen receptor positive breast cancer. However, the role of 27‐HC in lung adenocarcinoma is still unclear. Because bone metastasis is a main reason for the high mortality of lung adenocarcinoma, this study aimed to investigate the effect of 27‐HC on ...
Lishan Zhang, Ming Liu, Jinglei Liu, Xingkai Li, Ming Yang, Benhua Su, Yanliang Lin   +6 more
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7α-Hydroxylation of 27-hydroxycholesterol in human liver microsomes

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1992
Human liver microsomes were found to catalyze 7 alpha-hydroxylation of 27-hydroxycholesterol at a rate of up to about 0.2 nmol/mg protein per min. The product of the reaction, 5-cholestene-3 beta, 7 alpha, 27-triol, was identified by means of combined gas chromatography-mass spectrometry.
I, Björkhem, B, Nyberg, K, Einarsson
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Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes

The Journal of Steroid Biochemistry and Molecular Biology, 2017
Exosomes from cancer cells are rich sources of biomarkers and may contain elevated levels of lipids of diagnostic value. 27-Hydroxycholesterol (27-OHC) is associated with proliferation and metastasis in estrogen receptor positive (ER+) breast cancer.
Hanne, Roberg-Larsen, Kaja, Lund, Kristina Erikstad, Seterdal, Stian, Solheim, Tore, Vehus, Nina, Solberg, Stefan, Krauss, Elsa, Lundanes, Steven Ray, Wilson   +8 more
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27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells

Life Sciences, 2004
To study the effect of 27-hydroxycholesterol (27OHC) on the catabolism of sphingomyelin, we cultured endothelial cells (ECs) from human umbilical veins with 27OHC, then measured activities of acid sphingomyelinase (ASMase) and neutral sphingomyelinase (NSMase) and sphingomyelin consumption by using [14C]sphingomyelin, and determined NSMase mRNA ...
Qi, Zhou, Mark R, Band, Alvaro, Hernandez, Zonglin L, Liu, Fred A, Kummerow   +4 more
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27‐Hydroxycholesterol Exacerbates the Pathogenesis of Asthma

Immunology
ABSTRACT 27‐Hydroxycholesterol (27‐HC) is an oxidative metabolite of cholesterol and an oxysterol catalysed by the mitochondrial cytochrome P450 enzyme, sterol 27‐hydroxylase (CYP27A1). In addition to inducing the release of eosinophil chemotactic factors such as RANTES and Eotaxin, 27‐HC enhances the differentiation of lung ...
Ya Li, Xingyue Liu, Feifei Shang, Minzhu Niu, Jiaqi Yan, Minyu Xie, Xiangnan Tao, Han Huang, Wenwen Wu, Shu Dong, Yingzi Chen, Fan Wu, Shujun Guo, Yulin Du, Mengqing Hua, Chuanwang Song   +15 more
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An alternative pathway of reverse cholesterol transport: The oxysterol 27-hydroxycholesterol

Atherosclerosis, 2010
Reverse cholesterol transport, although not well understood, is an important mechanism in the pathophysiology of atherosclerosis. Macrophages can eliminate some cholesterol from atherosclerotic lesions by an oxidative mechanism involving sterol 27-hydroxylase. Patients with inherited "cerebrotendinous xanthomatosis" lack sterol 27-hydroxylase (CYP27A1)
Oliver, Weingärtner, Ulrich, Laufs, Michael, Böhm, Dieter, Lütjohann   +3 more
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Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis.

Chest, 2012
27-Hydroxycholesterol (27-OHC) is produced from cholesterol by sterol 27-hydroxylase as an intermediate in the biosynthesis pathway of bile acid. Recently, 27-OHC was reported to cause inflammation and apoptosis in various types of cells. The aim of this study was to assess the production of 27-OHC in the airways of patients with COPD and to elucidate ...
Takashi, Kikuchi, Hisatoshi, Sugiura, Akira, Koarai, Tomohiro, Ichikawa, Yoshiaki, Minakata, Kazuto, Matsunaga, Masanori, Nakanishi, Tsunahiko, Hirano, Keiichirou, Akamatsu, Satoru, Yanagisawa, Kanako, Furukawa, Hiroki, Kawabata, Masakazu, Ichinose   +12 more
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