Results 181 to 190 of about 1,842,116 (207)

Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes

The Journal of Steroid Biochemistry and Molecular Biology, 2017
Exosomes from cancer cells are rich sources of biomarkers and may contain elevated levels of lipids of diagnostic value. 27-Hydroxycholesterol (27-OHC) is associated with proliferation and metastasis in estrogen receptor positive (ER+) breast cancer.
Hanne, Roberg-Larsen, Kaja, Lund, Kristina Erikstad, Seterdal, Stian, Solheim, Tore, Vehus, Nina, Solberg, Stefan, Krauss, Elsa, Lundanes, Steven Ray, Wilson   +8 more
openaire   +2 more sources

Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients

Neuroscience Letters, 2004
Alterations in brain cholesterol metabolism and reduced 24S-hydroxycholesterol plasma levels have been described in Alzheimer's disease (AD) and vascular dementia (VD). We hypothesize that changes in peripheral cholesterol metabolism, such as alterations in the plasma levels of 27-hydroxycholesterol, might also be involved.
H, Kölsch, R, Heun, A, Kerksiek, K V, Bergmann, W, Maier, D, Lütjohann   +5 more
openaire   +2 more sources

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Nature Medicine, 2007
The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in the vasculature.
Michihisa, Umetani, Hideharu, Domoto, Andrew K, Gormley, Ivan S, Yuhanna, Carolyn L, Cummins, Norman B, Javitt, Kenneth S, Korach, Philip W, Shaul, David J, Mangelsdorf   +8 more
openaire   +2 more sources

An alternative pathway of reverse cholesterol transport: The oxysterol 27-hydroxycholesterol

Atherosclerosis, 2010
Reverse cholesterol transport, although not well understood, is an important mechanism in the pathophysiology of atherosclerosis. Macrophages can eliminate some cholesterol from atherosclerotic lesions by an oxidative mechanism involving sterol 27-hydroxylase. Patients with inherited "cerebrotendinous xanthomatosis" lack sterol 27-hydroxylase (CYP27A1)
Oliver, Weingärtner, Ulrich, Laufs, Michael, Böhm, Dieter, Lütjohann   +3 more
openaire   +2 more sources

Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol

2016
The estrogen receptors (ERs) belong to the nuclear receptor superfamily, and as such act as ligand inducible transcription factors, mediating the effects of estrogens. However, their pharmacology is complex, having the ability to be differentially activated by ligands.
openaire   +2 more sources

Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases

Ageing Research Reviews, 2021
J P Pais de Barros, M Hammami, John J Mackrill   +2 more
exaly  

The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation

Immunity, 2021
Bruno C Trindade, Simona Ceglia, Alyssa Berthelette   +2 more
exaly  

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease

Antioxidants, 2021
Paola Gamba, Serena Giannelli, Erica Staurenghi   +2 more
exaly  

4β‐Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half‐life of elimination after induction with rifampicin

British Journal of Clinical Pharmacology, 2009
Ulf Diczfalusy, Kajsa P Kanebratt, Tommy B Andersson   +2 more
exaly  

Time course of the increase in 4β‐hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy

British Journal of Clinical Pharmacology, 2008
Leif Bertilsson, Ulf Diczfalusy
exaly