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25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties [PDF]

International Journal of Molecular Sciences, 2021
Cholesterol is responsible for the plasticity of plasma membranes and is involved in physiological and pathophysiological responses. Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol.
Marco M Domingues, Barbara Gomes, Axel Hollmann   +2 more
exaly   +2 more sources

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Diclofenac inhibits 27-hydroxycholesterol-induced inflammation

Biochemical and Biophysical Research Communications, 2016
27-Hydroxycholesterol (27OHChol) is a cholesterol oxidation product that induces inflammation. In the current study we investigated the effects of diclofenac on inflammatory responses caused by 27OHChol using human monocyte/macrophage (THP-1) cells. Transcription and secretion of CCL2, CCL3, and CCL4 chemokines enhanced by 27OHChol were significantly ...
Bo-Young, Kim, Yonghae, Son, Seong-Kug, Eo, Young Chul, Park, Koanhoi, Kim   +4 more
openaire   +2 more sources

Oxysterols: 27-hydroxycholesterol and its radiolabeled analog

Steroids, 2000
We describe a convenient and stereoselective route to the synthesis of 27-hydroxycholesterol. Also its radiolabeled analog, 22, 23 di [(3)H]-27-hydroxycholesterol with high specific radioactivity (55 Ci/mmol) was synthesized by this method. Julia condensation of steroidal 22-sulfone with aldehyde, led to the addition of the 23-27 carbon side chain ...
T E, D'Ambra, N B, Javitt, J, Lacy, P, Srinivasan, T, Warchol   +4 more
openaire   +2 more sources

27‐Hydroxycholesterol Exacerbates the Pathogenesis of Asthma

Immunology
ABSTRACT 27‐Hydroxycholesterol (27‐HC) is an oxidative metabolite of cholesterol and an oxysterol catalysed by the mitochondrial cytochrome P450 enzyme, sterol 27‐hydroxylase (CYP27A1). In addition to inducing the release of eosinophil chemotactic factors such as RANTES and Eotaxin, 27‐HC enhances the differentiation of lung ...
Ya Li, Xingyue Liu, Feifei Shang, Minzhu Niu, Jiaqi Yan, Minyu Xie, Xiangnan Tao, Han Huang, Wenwen Wu, Shu Dong, Yingzi Chen, Fan Wu, Shujun Guo, Yulin Du, Mengqing Hua, Chuanwang Song   +15 more
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27‐Hydroxycholesterol enhanced osteoclastogenesis in lung adenocarcinoma microenvironment

Journal of Cellular Physiology, 2018
Abstract27‐Hydroxycholesterol (27‐HC) has been implicated in the pathological process of estrogen receptor positive breast cancer. However, the role of 27‐HC in lung adenocarcinoma is still unclear. Because bone metastasis is a main reason for the high mortality of lung adenocarcinoma, this study aimed to investigate the effect of 27‐HC on ...
Lishan Zhang, Ming Liu, Jinglei Liu, Xingkai Li, Ming Yang, Benhua Su, Yanliang Lin   +6 more
openaire   +2 more sources

27-hydroxycholesterol roles in respiratory disease pathogenesis

International Immunopharmacology
27-Hydroxycholesterol (27-HC) is an oxidative metabolite of cholesterol, enzymatically produced by the mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase (CYP27A1). Endogenous 27-HC maintains cholesterol homeostasis primarily via the selective inhibition of sterol regulatory element-binding protein 2 (SREBP-2). By binding to liver X receptors (
Ya, Li, Jiaqi, Yan, Chuanwang, Song
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7β-Hydroxycholesterol induces Ca2+ oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells

Atherosclerosis, 2000
In the present study, we characterize the early cytotoxic effects of 7β-hydroxycholesterol, a major cytotoxin in oxidized LDL, in human aortic smooth muscle cells. Within a few minutes after addition, 7β-hydroxycholesterol induced Ca 2+ oscillations with
Mikko P S Ares, Johan Thyberg, Lisa Juntti-Berggren   +2 more
exaly   +2 more sources

7α-Hydroxylation of 27-hydroxycholesterol in human liver microsomes

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1992
Human liver microsomes were found to catalyze 7 alpha-hydroxylation of 27-hydroxycholesterol at a rate of up to about 0.2 nmol/mg protein per min. The product of the reaction, 5-cholestene-3 beta, 7 alpha, 27-triol, was identified by means of combined gas chromatography-mass spectrometry.
I, Björkhem, B, Nyberg, K, Einarsson
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Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis.

Chest, 2012
27-Hydroxycholesterol (27-OHC) is produced from cholesterol by sterol 27-hydroxylase as an intermediate in the biosynthesis pathway of bile acid. Recently, 27-OHC was reported to cause inflammation and apoptosis in various types of cells. The aim of this study was to assess the production of 27-OHC in the airways of patients with COPD and to elucidate ...
Takashi, Kikuchi, Hisatoshi, Sugiura, Akira, Koarai, Tomohiro, Ichikawa, Yoshiaki, Minakata, Kazuto, Matsunaga, Masanori, Nakanishi, Tsunahiko, Hirano, Keiichirou, Akamatsu, Satoru, Yanagisawa, Kanako, Furukawa, Hiroki, Kawabata, Masakazu, Ichinose   +12 more
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Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol

Chemistry and Physics of Lipids, 2020
Oxysterols are cholesterol metabolites with multiple functions in controlling cellular homeostasis. In particular, 27-hydroxycholesterol (27-OH-Chol) has been shown to regulate a variety of physiological functions, but little is known about its uptake, intracellular trafficking, and efflux from cells.
Maria Szomek, Laust Moesgaard, Peter Reinholdt, Sophia Bell Haarhøj Hald, Daniel Petersen, Kathiresan Krishnan, Douglas F. Covey, Jacob Kongsted, Daniel Wüstner   +8 more
openaire   +3 more sources