Results 41 to 50 of about 11,352 (188)

The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice [PDF]

Gastroenterology, 2013
Non-alcoholic steatohepatitis is characterized by hepatic steatosis with inflammation. Although steatosis is benign and reversible, inflammation can increase liver damage. Hepatic inflammation has been associated with accumulation of cholesterol in lysosomes of Kupffer cells.
Bieghs, Veerle, Hendrikx, Tim, van Gorp, Patrick J., Verheyen, Fons, Guichot, Yasmin Dias, Walenbergh, Sofie M. A., Jeurissen, Mike L. J., Gijbels, Marion, Rensen, Sander S., Bast, Aalt, Plat, Jogchum, Kalhan, Satish C., Koek, Ger H., Leitersdorf, Eran, Hofker, Marten H., Lütjohann, Dieter, Shiri-Sverdlov, Ronit   +16 more
openaire   +5 more sources

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis

Journal of Lipid Research, 2010
Patients with a recessively inherited “pure” hereditary spastic paresis (SPG5) have mutations in the gene coding for the oxysterol 7 α hydroxylase (CYP7B1).
Rebecca Schüle, Teepu Siddique, Han-Xiang Deng, Yi Yang, Sandra Donkervoort, Magnus Hansson, Ricardo E. Madrid, Nailah Siddique, Ludger Schöls, Ingemar Björkhem   +9 more
doaj   +1 more source

SUN-590 27-Hydroxycholesterol Triggers the Whitening of Brown Adipose Tissue [PDF]

J Endocr Soc, 2020
Asghari A, Bui L, Stephen R, Umetani M.
europepmc   +3 more sources

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
doaj   +1 more source

The oncogenic roles of 27‑hydroxycholesterol in glioblastoma

Oncology Letters, 2019
Glioblastoma is the most frequent primary malignant brain tumor in adults. Oxysterols are oxidation products of cholesterol generated by enzymatic reactions. 27-hydroxycholesterol (27-HC), an oxysterol, is an abundant metabolite of cholesterol. 27-HC significantly accelerates mammary cancer growth, proliferation and progression in experimental models ...
Liu, Lu, Li, Mei-Yuan, Xing, Yu, Wang, Xiao-Yun, Wang, Yong   +4 more
openaire   +3 more sources

Cholesterol, oxysterol, triglyceride, and coenzyme Q homeostasis in ALS. Evidence against the hypothesis that elevated 27-hydroxycholesterol is a pathogenic factor.

PLoS ONE, 2014
High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease amyotrophic lateral sclerosis (ALS) and to be associated with increased survival time.
Anna Wuolikainen, Jure Acimovic, Anita Lövgren-Sandblom, Paolo Parini, Peter M Andersen, Ingemar Björkhem, Ingemar Björkhem   +6 more
doaj   +1 more source

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, EarlyView.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator [PDF]

Molecular Endocrinology, 2008
AbstractSelective estrogen receptor (ER) modulators (SERMs) are ER ligands whose relative agonist/antagonist activities vary in a cell- and promoter-dependent manner. The molecular basis underlying this selectivity can be attributed to the ability of these ligands to induce distinct alterations in ER structure leading to differential recruitment of ...
Carolyn D, DuSell, Michihisa, Umetani, Philip W, Shaul, David J, Mangelsdorf, Donald P, McDonnell   +4 more
openaire   +2 more sources