Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate [PDF]
Open Biology, 2013 Complex 3′-5′-cyclic diguanylic acid (c-di-GMP) responsive regulatory networks that are modulated by the action of multiple diguanylate cyclases (DGC; GGDEF domain proteins) and phosphodiesterases (PDE; EAL domain proteins) have evolved in many bacteria.
Melissa Lacey +3 more
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Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP
Pharmaceuticals, 2021 Cyclic guanosine-3′,5′-monophosphate, better known as cyclic-GMP or cGMP, is a classical second messenger involved in a variety of intracellular pathways ultimately controlling different physiological functions.
Ernesto Fedele, Roberta Ricciarelli
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Functional Analysis of the Expanded Phosphodiesterase Gene Family in Toxoplasma gondii Tachyzoites
mSphere, 2022 Toxoplasma motility is both activated and suppressed by 3′,5′-cyclic nucleotide signaling. Cyclic GMP (cGMP) signaling through Toxoplasma gondii protein kinase G (TgPKG) activates motility, whereas cyclic AMP (cAMP) signaling through TgPKAc1 inhibits ...
William J. Moss +3 more
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Microorganisms, 2021 Diguanylate cyclases (DGCs) and phosphodiesterases (PDEs) are essential enzymes deputed to maintain the intracellular homeostasis of the second messenger cyclic dimeric (3′→5′) GMP (c-di-GMP).
Desirèe Nuzzo +3 more
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Frontiers in Plant Science, 2021 Azospirillum baldaniorum is a plant growth-promoting rhizobacterium (PGPR) capable of fixing nitrogen, the synthesis of several phytohormones including indole-acetic acid, and induction of plant defenses against phytopathogens.
Daniel Sierra Cacho +5 more
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Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence [PDF]
Proceedings of the National Academy of Sciences, 2006 The opportunistic pathogen Pseudomonas aeruginosa is responsible for systemic infections in immunocompromised individuals and chronic respiratory disease in patients with cystic fibrosis. Cyclic nucleotides are known to play a variety of roles in the regulation of virulence-related factors in pathogenic bacteria.
Kulesekara, Hemantha +11 more
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Correction for Kulasakara et al., Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence [PDF]
Proceedings of the National Academy of Sciences, 2006 microbiology . For the article “Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence,” by Hemantha Kulesekara, Vincent …
Hemantha Kulasakara +11 more
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Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases [PDF]
, 2017 The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs)
A Deepthi +70 more
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BMC Genomics, 2022 Background Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a bacterial second messenger that affects diverse processes in different bacteria, including the cell cycle, motility, and biofilm formation.
Sonja Koppenhöfer, Andrew S. Lang
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Comparative genomics analysis of c-di-GMP metabolism and regulation in Microcystis aeruginosa
BMC Genomics, 2020 Background Cyanobacteria are of special concern because they proliferate in eutrophic water bodies worldwide and affect water quality. As an ancient photosynthetic microorganism, cyanobacteria can survive in ecologically diverse habitats because of their
Meng Chen +5 more
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