Results 11 to 20 of about 4,140 (67)

Demonstration, in leukemia L-1210 cells, of a phosphodiesterase acting on 3':5'-cyclic CMP but not on 3':5'-cyclic AMP or 3':5'-cyclic GMP.

Journal of Biological Chemistry, 1978
cCMP-specific phosphodiesterase activity was demonstrated in the 80 to 100% ammonium sulfate fraction obtained from disrupted leukemia L-1210 cells. The activity was linear with time (up to 60 min), was a function of protein concentration, and was markedly stimulated by Mg2+ and by ammonium sulfate.
Cheng, Y, Bloch, A
openaire   +2 more sources

Discovery of Novel c-di-GMP-Related Genes in Leptospira interrogans

Pathogens
Cyclic di-GMP (bis-(3′→5′) cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation.
Anielle Salviano de Almeida Ferrari, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Gabriela Roberto Silva, Cauê Augusto Boneto Gonçalves, Daniel Enrique Sanchez-Limache, Bruna Sayuri Cardoso Ogusku, Anacleto Silva de Souza, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +9 more
doaj   +1 more source

c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa

mSphere
The universal bacterial second messenger bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) plays critical roles in regulating a variety of bacterial functions such as biofilm formation and virulence.
Qishun Feng, Xin Dai, Qiulan Wu, Lianhui Zhang, Liang Yang, Yang Fu   +5 more
doaj   +1 more source

Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity.
Leonard Chiu, Vineet Agrawal, David Armstrong, Evan Brittain, Sheila Collins, Anna R. Hemnes, Joseph A. Hill, JoAnn Lindenfeld, Sanjiv J. Shah, Lynne W. Stevenson, Thomas J. Wang, Deepak K. Gupta   +11 more
doaj   +1 more source

Structural and biochemical insights into the inhibition of <i>Mycobacterium tuberculosis</i> cyclic dinucleotide phosphodiesterase by a sulfur-modified cyclic dinucleotide analog. [PDF]

RSC Chem Biol
Hanuman DS, Neeharika S, Murari SK, Yeboah SK, Sintim HO, Rajakumara E.   +5 more
europepmc   +1 more source

Redox Imbalance and NOS-Dependent Modulation of Superoxide in the Bladder Mucosa of Women With IC/BPS: A Preliminary Study. [PDF]

J Cell Mol Med
de Oliveira MG, Antunes E, Passos GR, Brito LGO, D'Ancona CAL, Monica FZ.   +5 more
europepmc   +1 more source

Emerging roles of pterins as signaling molecules in bacteria. [PDF]

Biochem Soc Trans
Rucker P, Augusta L, Fuqua C, Allen KD.
europepmc   +1 more source

Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation. [PDF]

PLoS Genet
Cınar Cakmak B, Saric JD, Wrede K, Holmes NA, Haist J, Schumacher MA, Buttner MJ, Tschowri N.   +7 more
europepmc   +1 more source

Oxygen-responsive KoBdcA/KoBdcB/KoBpdA system regulates c-di-GMP levels to control bacterial cellulose biosynthesis and motility in <i>Kosakonia oryzendophytica</i> FY-07. [PDF]

Microbiol Spectr
Zhao X, Shi Y, Tian W, Tian Y, Hu C, Guo Z, Ma T, Li G, Gao G.   +8 more
europepmc   +1 more source

Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases. [PDF]

Cells
Vennard CS, Oladeji SM, Sintim HO.
europepmc   +1 more source