Results 1 to 10 of about 2,432 (111)

Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts

Life, 2021
GGDEF-containing proteins respond to different environmental cues to finely modulate cyclic diguanylate (c-di-GMP) levels in time and space, making the allosteric control a distinctive trait of the corresponding proteins.
Federico Mantoni, Loredana Cappellacci, Alessandro Paiardini   +2 more
exaly   +3 more sources

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases [PDF]

Microbial Biotechnology
The nearly ubiquitous second messenger cyclic di‐GMP signalling system decides about the bacterial lifestyle transition between sessility and motility. GGDEF diguanylate cyclase and EAL phosphodiesterase domains conventionally conduct the turnover of the
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
doaj   +2 more sources

Diverse Biological Functions and Domain-Specific Interactions of the Diguanylate Cyclase PA2072 in Pseudomonas aeruginosa PAO1 [PDF]

International Journal of Microbiology
Nucleotide bis-(3,5)-cyclic di-guanosine monophosphate (c-di-GMP) is a universal and versatile secondary messenger. It is involved in the regulation of significant functions such as motility, biofilm formation, virulence, drug resistance, cell cycle ...
Xiaojing Gao, Yan Zhang, Lingna Guo, Huimin Zhang, Jianwen Sun, Jianfang Sun, Weidong Huang   +6 more
doaj   +2 more sources

Expression Patterns, Genomic Conservation and Input Into Developmental Regulation of the GGDEF/EAL/HD-GYP Domain Proteins in Streptomyces

Frontiers in Microbiology, 2018
To proliferate, antibiotic-producing Streptomyces undergo a complex developmental transition from vegetative growth to the production of aerial hyphae and spores.
Sara Alina Neumann, Mahmoud Al-Bassam, Natalia Tschowri   +2 more
exaly   +3 more sources

Retrieving of diguanylate cyclases responsible for biofilm formation and antibiotic resistance in Acinetobacter baumannii [PDF]

BMC Microbiology
Background As a common opportunistic nosocomial pathogen, Acinetobacter baumannii has emerged as an increasingly multidrug-resistant threat due to its strong biofilm lifestyle. The GGDEF/EAL domain proteins regulate c-di-GMP metabolism, thereby affecting
Boqiao Li, Ling Zou, Xiaobo Liu
doaj   +2 more sources

Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation. [PDF]

PLoS Genetics
Soil bacteria of the genus Streptomyces are natural producers of over two-thirds of clinically used antibiotics. Their ability to generate these valuable metabolites is tightly linked to a developmental program involving the transition from vegetative ...
Buse Cınar Cakmak, Johanna D Saric, Katrin Wrede, Neil A Holmes, Julian Haist, Maria A Schumacher, Mark J Buttner, Natalia Tschowri   +7 more
doaj   +2 more sources

Discovery of Novel c-di-GMP-Related Genes in Leptospira interrogans [PDF]

Pathogens
Cyclic di-GMP (bis-(3′→5′) cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation.
Anielle Salviano de Almeida Ferrari, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Gabriela Roberto Silva, Cauê Augusto Boneto Gonçalves, Daniel Enrique Sanchez-Limache, Bruna Sayuri Cardoso Ogusku, Anacleto Silva de Souza, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +9 more
doaj   +2 more sources

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption [PDF]

Microbial Biotechnology
The second messenger bis‐(3′ → 5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, Pablo I. Nikel, Andrea M. Smania   +5 more
doaj   +2 more sources

Investigations on genomic, topological and structural properties of diguanylate cyclases involved in Vibrio cholerae biofilm signalling using in silico techniques: Promising drug targets in combating cholera [PDF]

Current Research in Structural Biology
During various stages of its life cycle, Vibrio cholerae initiate biofilm signalling cascade. Intercellular high level of the signalling nucleotide 3′-5′ cyclic dimeric guanosine monophosphate (c-di-GMP), synthesized by diguanylate cyclases (DGCs) from ...
Tuhin Manna, Subhamoy Dey, Monalisha Karmakar, Amiya Kumar Panda, Chandradipa Ghosh   +4 more
doaj   +2 more sources

Diguanylate Cyclase GdpX6 with c-di-GMP Binding Activity Involved in the Regulation of Virulence Expression in Xanthomonas oryzae pv. oryzae

Microorganisms, 2021
Cyclic diguanylate monophosphate (c-di-GMP) is a secondary messenger present in bacteria. The GGDEF-domain proteins can participate in the synthesis of c-di-GMP as diguanylate cyclase (DGC) or bind with c-di-GMP to function as a c-di-GMP receptor. In the
Weiwei Yan, Yiming Wei, Susu Fan, Chao Yu, Fang Tian, Qi Wang, Fenghuan Yang, Huamin Chen   +7 more
doaj   +1 more source