Results 1 to 10 of about 4,652 (199)

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases [PDF]

Microbial Biotechnology
The nearly ubiquitous second messenger cyclic di‐GMP signalling system decides about the bacterial lifestyle transition between sessility and motility. GGDEF diguanylate cyclase and EAL phosphodiesterase domains conventionally conduct the turnover of the
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
doaj   +3 more sources

Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts [PDF]

Life, 2021
GGDEF-containing proteins respond to different environmental cues to finely modulate cyclic diguanylate (c-di-GMP) levels in time and space, making the allosteric control a distinctive trait of the corresponding proteins.
Federico Mantoni, Alessandro Paiardini, Adele Di Matteo   +2 more
exaly   +8 more sources

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption [PDF]

Microbial Biotechnology
The second messenger bis‐(3′ → 5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, Pablo I. Nikel, Andrea M. Smania   +5 more
doaj   +3 more sources

PafS Containing GGDEF-Domain Regulates Life Activities of Pseudomonas glycinae MS82

Microorganisms, 2022
Cyclic dimeric guanosine monophosphate (c-di-GMP) is synthesized by diguanylate cyclase (DGC) with the GGDEF domain. As a ubiquitous bacterial second messenger, it regulates diverse life-activity phenotypes in some bacteria.
Xianyi Chen, Shaoxuan Qu, Xin Luo, Shi-En Lu, Youzhou Liu, Huiping Li, Lijuan Hou, Jinsheng Lin, Ning Jiang, Lin Ma   +9 more
doaj   +3 more sources

Expression Patterns, Genomic Conservation and Input Into Developmental Regulation of the GGDEF/EAL/HD-GYP Domain Proteins in Streptomyces

Frontiers in Microbiology, 2018
To proliferate, antibiotic-producing Streptomyces undergo a complex developmental transition from vegetative growth to the production of aerial hyphae and spores.
Mahmoud M Al-Bassam, Sara Alina Neumann, Natalia Tschowri   +2 more
exaly   +3 more sources

Domain architecture of the Mycobacterium tuberculosis MabR (Rv2242), a member of the PucR transcription factor family [PDF]

Heliyon
MabR (Rv2242), a PucR-type transcription factor, plays a crucial role in regulating mycolic acid biosynthesis in Mycobacterium tuberculosis. To understand its regulatory mechanisms, we determined the crystal structures of its N-terminal and C-terminal ...
Véronique Megalizzi, Abdalkarim Tanina, Camille Grosse, Manon Mirgaux, Pierre Legrand, Gaëtan Dias Mirandela, Alexandre Wohlkönig, Pablo Bifani, René Wintjens   +8 more
doaj   +2 more sources

Diguanylate Cyclase GdpX6 with c-di-GMP Binding Activity Involved in the Regulation of Virulence Expression in Xanthomonas oryzae pv. oryzae

Microorganisms, 2021
Cyclic diguanylate monophosphate (c-di-GMP) is a secondary messenger present in bacteria. The GGDEF-domain proteins can participate in the synthesis of c-di-GMP as diguanylate cyclase (DGC) or bind with c-di-GMP to function as a c-di-GMP receptor. In the
Weiwei Yan, Yiming Wei, Susu Fan, Chao Yu, Fang Tian, Qi Wang, Fenghuan Yang, Huamin Chen   +7 more
doaj   +1 more source

Patterns of abundance, chromosomal localization, and domain organization among c-di-GMP-metabolizing genes revealed by comparative genomics of five alphaproteobacterial orders

BMC Genomics, 2022
Background Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a bacterial second messenger that affects diverse processes in different bacteria, including the cell cycle, motility, and biofilm formation.
Sonja Koppenhöfer, Andrew S. Lang
doaj   +1 more source

Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate

Nature Communications, 2023
Previous studies have demonstrated that bis-(3',5')-cyclic diguanosine monophosphate (bis-3',5'-c-di-GMP) is a ubiquitous second messenger employed by bacteria. Here, we report that 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) controls the important
Xia Li, Wenfang Yin, Junjie Desmond Lin, Yong Zhang, Quan Guo, Gerun Wang, Xiayu Chen, Binbin Cui, Mingfang Wang, Min Chen, Peng Li, Ya-Wen He, Wei Qian, Haibin Luo, Lian-Hui Zhang, Xue-Wei Liu, Shihao Song, Yinyue Deng   +17 more
doaj   +1 more source

Production of 3',3'-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility.

PLoS Genetics, 2022
Bacterial second messengers are important for regulating diverse bacterial lifestyles. Cyclic di-GMP (c-di-GMP) is produced by diguanylate cyclase enzymes, named GGDEF proteins, which are widespread across bacteria.
Rebecca C Lowry, Zachary F Hallberg, Rob Till, Tyler J Simons, Ruth Nottingham, Fiona Want, R Elizabeth Sockett, Ming C Hammond, Carey Lambert   +8 more
doaj   +1 more source