Modulation of biofilm-formation in Salmonella enterica serovar Typhimurium by the periplasmic DsbA/DsbB oxidoreductase system requires the GGDEF-EAL domain protein STM3615. [PDF]
PLoS ONE, 2014 In Salmonella enterica serovar Typhimurium (S. Typhimurium), biofilm-formation is controlled by the cytoplasmic intracellular small-molecular second messenger cyclic 3', 5'-di- guanosine monophosphate (c-di-GMP) through the activities of GGDEF and EAL ...
Naeem Anwar +3 more
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Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]
, 2012 In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in
BMC Microbiology, 2012 Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections.
Cruz Diana P +4 more
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Molecular Plant-Microbe Interactions, 2014 Degenerate GGDEF and EAL domain proteins represent major types of cyclic diguanylic acid (c-di-GMP) receptors in pathogenic bacteria. Here, we characterized a FimX-like protein (Filp) which possesses both GGDEF and EAL domains in Xanthomonas oryzae pv ...
Fenghuan Yang +7 more
doaj +1 more source
Characterization of the Xylella fastidiosa PD1671 gene encoding degenerate c-di-GMP GGDEF/EAL domains, and its role in the development of Pierce's disease. [PDF]
PLoS ONE, 2015 Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce's disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of ...
Luciana Cursino +9 more
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A Staphylococcal GGDEF Domain Protein Regulates Biofilm Formation Independently of Cyclic Dimeric GMP [PDF]
Journal of Bacteriology, 2008 ABSTRACTCyclic dimeric GMP (c-di-GMP) is an important biofilm regulator that allosterically activates enzymes of exopolysaccharide biosynthesis. Proteobacterial genomes usually encode multiple GGDEF domain-containing diguanylate cyclases responsible for c-di-GMP synthesis.
Linda M, Holland +7 more
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Proteins with GGDEF and EAL domains regulatePseudomonas putidabiofilm formation and dispersal [PDF]
FEMS Microbiology Letters, 2006 Microbial biofilm formation often causes problems in medical and industrial settings, and knowledge about the factors that are involved in biofilm development and dispersion is useful for creating strategies to control the processes. In this report, we present evidence that proteins with GGDEF and EAL domains are involved in the regulation of biofilm ...
Morten, Gjermansen +2 more
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Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate [PDF]
Open Biology, 2013 Complex 3′-5′-cyclic diguanylic acid (c-di-GMP) responsive regulatory networks that are modulated by the action of multiple diguanylate cyclases (DGC; GGDEF domain proteins) and phosphodiesterases (PDE; EAL domain proteins) have evolved in many bacteria.
Melissa Lacey +3 more
doaj +1 more source
A Zinc Lock on GGDEF Domain Dimerization Inhibits E. coli Biofilms [PDF]
Structure, 2013 In this issue of Structure, Zähringer and colleagues present crystal structures of an important signal transduction enzyme, diguanylate cyclase DgcZ from E. coli. The authors show that zinc ions bound to the CZB domain inhibit enzyme activity and reveal how zinc availability affects biofilm formation.
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The structure–function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain [PDF]
Microbiology, 2007 The GGDEF response regulator WspR couples the chemosensory Wsp pathway to the overproduction of acetylated cellulose and cell attachment in the Pseudomonas fluorescens SBW25 wrinkly spreader (WS) genotype. Here, it is shown that WspR is a diguanylate cyclase (DGC), and that DGC activity is elevated in the WS genotype compared to that in the ancestral ...
Malone, J. G. +5 more
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