Results 31 to 40 of about 3,106 (185)

Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation. [PDF]

Protein Sci
Abstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Fuchs M, Winkler A.
europepmc   +2 more sources

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption [PDF]

Microbial Biotechnology
The second messenger bis‐(3′ → 5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, Pablo I. Nikel, Andrea M. Smania   +5 more
doaj   +2 more sources

Investigations on genomic, topological and structural properties of diguanylate cyclases involved in Vibrio cholerae biofilm signalling using in silico techniques: Promising drug targets in combating cholera [PDF]

Current Research in Structural Biology
During various stages of its life cycle, Vibrio cholerae initiate biofilm signalling cascade. Intercellular high level of the signalling nucleotide 3′-5′ cyclic dimeric guanosine monophosphate (c-di-GMP), synthesized by diguanylate cyclases (DGCs) from ...
Tuhin Manna, Subhamoy Dey, Monalisha Karmakar, Amiya Kumar Panda, Chandradipa Ghosh   +4 more
doaj   +2 more sources

Rôle des protéines à domaines GGDEF et/ou EAL chez Legionella pneumophila

, 2011
Legionella pneumophila est un pathogène intracellulaire, agent de la Légionellose, et dont le réservoir dans l’environnement est constitué d’amibes aquatiques comme Acanthamoeba castellani. Mes objectifs de thèse étaient l’identification de mécanismes moléculaires contrôlant la virulence et la multi-résistance chez L.
Levet-Paulo, Mélanie, Levet, Levet-Paulo, Mélanie,   +1 more
openaire   +2 more sources

Diguanylate Cyclase GdpX6 with c-di-GMP Binding Activity Involved in the Regulation of Virulence Expression in Xanthomonas oryzae pv. oryzae

Microorganisms, 2021
Cyclic diguanylate monophosphate (c-di-GMP) is a secondary messenger present in bacteria. The GGDEF-domain proteins can participate in the synthesis of c-di-GMP as diguanylate cyclase (DGC) or bind with c-di-GMP to function as a c-di-GMP receptor. In the
Weiwei Yan, Yiming Wei, Susu Fan, Chao Yu, Fang Tian, Qi Wang, Fenghuan Yang, Huamin Chen   +7 more
doaj   +1 more source

Patterns of abundance, chromosomal localization, and domain organization among c-di-GMP-metabolizing genes revealed by comparative genomics of five alphaproteobacterial orders

BMC Genomics, 2022
Background Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a bacterial second messenger that affects diverse processes in different bacteria, including the cell cycle, motility, and biofilm formation.
Sonja Koppenhöfer, Andrew S. Lang
doaj   +1 more source

Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate

Nature Communications, 2023
Previous studies have demonstrated that bis-(3',5')-cyclic diguanosine monophosphate (bis-3',5'-c-di-GMP) is a ubiquitous second messenger employed by bacteria. Here, we report that 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) controls the important
Xia Li, Wenfang Yin, Junjie Desmond Lin, Yong Zhang, Quan Guo, Gerun Wang, Xiayu Chen, Binbin Cui, Mingfang Wang, Min Chen, Peng Li, Ya-Wen He, Wei Qian, Haibin Luo, Lian-Hui Zhang, Xue-Wei Liu, Shihao Song, Yinyue Deng   +17 more
doaj   +1 more source

Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus [PDF]

Molecular Microbiology, 2003
SummarySeveral members of the two‐component signal transduction family have been implicated in the control of  polar development in Caulobacter crescentus: PleC and DivJ, two polarly localized histidine sensor kinases; and the response regulators DivK and PleD.
Aldridge, P., Paul, R., Goymer, P., Rainey, P., Jenal, U.   +4 more
openaire   +4 more sources

Production of 3',3'-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility.

PLoS Genetics, 2022
Bacterial second messengers are important for regulating diverse bacterial lifestyles. Cyclic di-GMP (c-di-GMP) is produced by diguanylate cyclase enzymes, named GGDEF proteins, which are widespread across bacteria.
Rebecca C Lowry, Zachary F Hallberg, Rob Till, Tyler J Simons, Ruth Nottingham, Fiona Want, R Elizabeth Sockett, Ming C Hammond, Carey Lambert   +8 more
doaj   +1 more source

Role of the GGDEF protein family in Salmonella cellulose biosynthesis and biofilm formation [PDF]

Molecular Microbiology, 2004
Summary Salmonella enterica serovar Typhimurium is capable of producing cellulose as the main exopolysaccharide compound of the biofilm matrix. It has been shown for Gluconacetobacter xylinum that cellulose biosynthesis is allosterically regulated by bis‐(3′,5′) cyclic diguanylic acid, whose synthesis/degradation depends on diguanylate cyclase ...
García, Begoña, Latasa Osta, Cristina, Solano Goñi, Cristina, García del Portillo, Francisco, Gamazo de la Rasilla, Carlos, Lasa, Íñigo   +5 more
openaire   +3 more sources