The HD-GYP domain protein RpfG of Xanthomonas oryzae pv. oryzicola regulates synthesis of extracellular polysaccharides that contribute to biofilm formation and virulence on rice. [PDF]
PLoS ONE, 2013 Bacterial leaf streak caused by Xanthomonas oryzae pv. oryzicola (Xoc) is one of the most important diseases in rice. However, little is known about the pathogenicity mechanisms of Xoc.
Yuanbao Zhang +7 more
doaj +22 more sources
Expression Patterns, Genomic Conservation and Input Into Developmental Regulation of the GGDEF/EAL/HD-GYP Domain Proteins in Streptomyces [PDF]
Frontiers in Microbiology, 2018 To proliferate, antibiotic-producing Streptomyces undergo a complex developmental transition from vegetative growth to the production of aerial hyphae and spores.
Mahmoud M. Al-Bassam +4 more
doaj +7 more sources
A systematic analysis of the in vitro and in vivo functions of the HD-GYP domain proteins of Vibrio cholerae [PDF]
BMC Microbiology, 2014 Background The second messenger cyclic diguanylate (c-di-GMP) plays a central role in bacterial adaptation to extracellular stimuli, controlling processes such as motility, biofilm development, cell development and, in some pathogens, virulence.
Benjamin Mudrak, Rita Tamayo
exaly +8 more sources
C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG. [PDF]
PLoS ONE, 2013 In biofilms, the bacterial community optimizes the strategies to sense the environment and to communicate from cell to cell. A key player in the development of a bacterial biofilm is the second messenger c-di-GMP, whose intracellular levels are modulated
Valentina Stelitano +5 more
doaj +6 more sources
Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre. [PDF]
Mol Microbiol, 2014 Bis-(3′,5′) cyclic di-guanylate (c-di-GMP) is a key bacterial second messenger that is implicated in the regulation of many crucial processes that include biofilm formation, motility and virulence.
Bellini D +7 more
europepmc +10 more sources
The Structure of an Unconventional HD-GYP Protein from
mBio, 2011 Cyclic-di-GMP is a near-ubiquitous bacterial second messenger that is important in localized signal transmission during the control of various processes, including virulence and switching between planktonic and biofilm-based lifestyles.
Andrew L. Lovering +4 more
doaj +5 more sources
Patterns of abundance, chromosomal localization, and domain organization among c-di-GMP-metabolizing genes revealed by comparative genomics of five alphaproteobacterial orders [PDF]
BMC Genomics, 2022 Background Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a bacterial second messenger that affects diverse processes in different bacteria, including the cell cycle, motility, and biofilm formation.
Sonja Koppenhöfer, Andrew S. Lang
doaj +2 more sources
Structural analyses uncover protease-adhesin interactions and c-di-GMP receptor regulation in sulfate-reducing bacteria [PDF]
Nature CommunicationsDesulfovibrio vulgaris is a sulfate-reducing organism with biofim-forming capacity relevant for bioremediation and microbe-induced corrosion. Biofilm formation of D. vulgaris depends on two large adhesins that are regulated by proteins encoded in the Dvh
Maria E. Font +6 more
doaj +2 more sources
A nitric oxide-sensing two-component system regulates a range of infection-related phenotypes in Burkholderia pseudomallei [PDF]
mSphereThe tier 1 bioterrorism agent Burkholderia pseudomallei causes melioidosis, a tropical disease with fatality rates that can exceed 40% despite antibiotic therapy.
Matthew W. Scurlock +2 more
doaj +2 more sources
Improving the cultivated rice Sakha104 (Oryza sativa L.) using gene pools of some relative wild species [PDF]
PeerJBackground Rice (Oryza sativa L.) is considered a staple food for one-half of the world’s population. The yield of rice must increase to keep up with the world’s population growth.
Walid H. Elgamal +6 more
doaj +3 more sources