Results 41 to 50 of about 104,269 (134)

Farmland abandonment and season drive scavenging dynamics in livestock‐rewilded landscapes

Ecological Applications, Volume 35, Issue 8, December 2025.
Abstract Farmland abandonment occurs commonly across European mountain regions, which causes triggering of habitat encroachment through shrub regeneration and natural afforestation. However, its impact on vertebrate scavenger communities and ecological processes, such as the removal of small carcasses remains poorly understood.
Rocío R. Daza, Pablo Acebes, Pedro P. Olea   +2 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, Volume 5, Issue 9, September 2025.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Antidopaminergic Medications and Clinical Changes in Measures of Huntington's Disease: A Causal Analysis

Movement Disorders, Volume 40, Issue 5, Page 928-937, May 2025.
Abstract Background Antidopaminergic medications (ADM) are often used for symptom management of Huntington's disease (HD). Evidence from past research suggests that ADMs are associated with worse clinical outcomes in HD, but their impact on various domains remains underexplored.
Michal Geva, Y. Paul Goldberg, Henk Schuring, Andrew M. Tan, Jeffrey D. Long, Michael R. Hayden   +5 more
wiley   +1 more source

Active Site Metal Occupancy and Cyclic Di-GMP Phosphodiesterase Activity of Thermotoga maritima HD-GYP

, 2016
HD-GYPs make up a subclass of the metal-dependent HD phosphohydrolase superfamily and catalyze conversion of cyclic di­(3′,5′)-guanosine monophosphate (c-di-GMP) to 5′-phosphoguanylyl-(3′→5′)-guanosine (pGpG) and GMP. Until now, the only reported crystal
Kyle D. Miner (1322889), Donald M. Kurtz (1321203)   +1 more
core   +1 more source

NMR Solution Structure of the N‐Terminal GSPII Domain from the Thermus Thermophilus Traffic ATPase PilF and Reconstruction of its c‐di‐GMP Binding Capability

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
GSPII‐A is the first of three consecutive GSPII domains of PilF from Thermus thermophilus and the only one that does not bind c‐di‐GMP. In this study we solve the structure of GSPII‐A and show the key factors hindering c‐di‐GMP binding. Through mutagenesis, we elucidate the minimal motif conservation needed for c‐di‐GMP recognition. Abstract The cyclic
Konstantin Neißner, Carolin Frohnapfel, Heiko Keller, Elke Duchardt‐Ferner, Vanessa Schneider, Zeinab Kamjou, Beate Averhoff, Jens Wöhnert   +7 more
wiley   +1 more source

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption

Microbial Biotechnology, Volume 18, Issue 4, April 2025.
All 32 diguanylate cyclase (DGC)‐encoding genes of P. aeruginosa PA14 were interrupted by premature STOP codons, introduced through a multiplexed cytosine base‐editor. The synthesis of c‐di‐GMP was impaired in the resulting strain lacking all 32 DGCs (strain PA14Δ32). Phenotypic analysis confirmed major behaviour changes in P. aeruginosa PA14Δ32, which
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, Pablo I. Nikel, Andrea M. Smania   +5 more
wiley   +1 more source

Balancing ecotourism and wildlife management through a conservation behavior approach

Conservation Science and Practice, Volume 7, Issue 3, March 2025.
We surveyed ecologists, conservationists, and ecotourism professionals to investigate consequences of ecotourism on animal behavior. We highlight four main behavioral themes and solutions for engendering more sustainable ecotourism that mitigates behavioral impacts.
Rachel Y. Chock, Eduardo Bessa, Josue David Arteaga‐Torres, Liv Baker, Richard Buchholz, Barbara Clucas, Cassandra Nuñez, Gabriela M. Pinho, Bruce A. Schulte, Daniel T. Blumstein, Bernard Kitheka, Alexander G. Allison, J. Edgardo Arevalo, Debra A. Hamilton, Claudio M. Monteza‐Moreno, Laney H. Nute, Javier Rodríguez‐Fonseca, Luis Sandoval, Jessica Stamn, Jennifer L. Verdolin, Lynn Von Hagen, Jimmy W. Wehsener, Brett M. Seymoure   +22 more
wiley   +1 more source

Vibrio cholerae V‑cGAP3 Is an HD-GYP Phosphodiesterase with a Metal Tunable Substrate Selectivity

, 2022
Cyclic dinucleotides (CDNs) are signaling molecules involved in the immune response and virulence factor production. CDN cellular levels are fine-tuned by metal-dependent phosphodiesterases (PDEs), among which HD-GYPs make up a subclass of the larger HD ...
Sining Sun (8976038), Richard Wang (84158), Maria-Eirini Pandelia (1327917)   +2 more
core   +1 more source

Environmental determinants of West Nile virus vector abundance at the wildlife–livestock interface Determinantes ambientales de la abundancia de vectores del virus del Nilo Occidental en la interfaz fauna‐ganado

Medical and Veterinary Entomology, Volume 39, Issue 1, Page 200-215, March 2025.
Mosquito communities in southern inland Iberia are dominated by highly competent vectors of West Nile virus. The coexistence of Culex pipiens and Culex theileri in southern inland Iberia indicates that both species should be involved in West Nile virus transmission.
Laia Casades‐Martí, Alfonso Peralbo‐Moreno, Sarah Delacour‐Estrella, Francisco Ruiz‐Fons   +3 more
wiley   +1 more source

Avian Influenza Screening in Captive Wild Birds and Biosecurity Appraisal of Zoological Gardens in Southwestern Nigeria

Veterinary Medicine International, Volume 2025, Issue 1, 2025.
Avian influenza (AI) is a severe respiratory disease affecting wild and domestic birds globally. There is currently no approved vaccine for AI control in Nigeria. Therefore, biosecurity measures remain the primary preventive strategy. However, there is limited information on the AI carrier status of captive wild birds and the implementation of ...
Ridwan Olamilekan Adesola, Adetolase Azizat Bakre, Bamidele Nyemike Ogunro, Oladipo Omotosho, Oluwaseun Adeolu Ogundijo, Clement Adebajo Meseko, Bitrus Inuwa, Abdulafees Hamzat, Luqman Adeola Balogun, Damilola John Gbore, Usman Opeyemi Olatunji, Delower Hossain, Babatunde Ibrahim Olowu, Valentine Chidalu Okeke, Tomiwa Adisa, Quadri Olanrewaju Raji, Sodiq Tolase, Abdulhakeem Binhambali, Lipi Buch   +18 more
wiley   +1 more source