Results 21 to 30 of about 137,432 (128)

Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre. [PDF]

Mol Microbiol, 2014
Bis-(3',5') cyclic di-guanylate (c-di-GMP) is a key bacterial second messenger that is implicated in the regulation of many crucial processes that include biofilm formation, motility and virulence.
Bellini D, Caly DL, McCarthy Y, Bumann M, An SQ, Dow JM, Ryan RP, Walsh MA.   +7 more
europepmc   +2 more sources

Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris. [PDF]

Proc Natl Acad Sci U S A, 2010
RpfG is a paradigm for a class of widespread bacterial two-component regulators with a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain.
Ryan RP, McCarthy Y, Andrade M, Farah CS, Armitage JP, Dow JM.   +5 more
europepmc   +2 more sources

Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover.

Proc Natl Acad Sci U S A, 2006
HD-GYP is a protein domain of unknown biochemical function implicated in bacterial signaling and regulation. In the plant pathogen Xanthomonas campestris pv.
Ryan RP, Fouhy Y, Lucey JF, Crossman LC, Spiro S, He YW, Zhang LH, Heeb S, Cámara M, Williams P, Dow JM.   +10 more
europepmc   +2 more sources

c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases. [PDF]

PLoS Genetics, 2011
Clostridium difficile infections have become a major healthcare concern in the last decade during which the emergence of new strains has underscored this bacterium's capacity to cause persistent epidemics.
Eric Bordeleau, Louis-Charles Fortier, François Malouin, Vincent Burrus   +3 more
doaj   +1 more source

Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation

Frontiers in Chemistry, 2020
The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho, R. Grant Tryon, Jeong-Ho Kim   +2 more
doaj   +1 more source

The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of Xanthomonas campestris [PDF]

, 2014
A cell-cell signalling system mediated by the fatty acid signal DSF controls the virulence of Xanthomonas campestris pv. campestris (Xcc) to plants. The synthesis and recognition of the DSF signal depends upon different Rpf proteins.
An, Shi Qi, Allan, John H., An, Shi-Qi, Dow, J. Maxwell, Febrer, Melanie, McCarthy, Yvonne, Ryan, Robert P.   +6 more
core   +1 more source

Identification of the Regulatory Components Mediated by the Cyclic di-GMP Receptor Filp and Its Interactor PilZX3 and Functioning in Virulence of Xanthomonas oryzae pv. oryzae

Molecular Plant-Microbe Interactions, 2020
The degenerate GGDEF/EAL domain protein Filp was previously shown to function as a cyclic di-GMP (c-di-GMP) signal receptor through its specific interaction with an atypical PilZ domain protein PilZX3 (formerly PXO_02715) and that this interaction is ...
Muhammad Umar Shahbaz, Shanshan Qian, Fei Yun, Jie Zhang, Chao Yu, Fang Tian, Fenghuan Yang, Huamin Chen   +7 more
doaj   +1 more source

Identification of a cyclic-di-GMP-modulating response regulator that impacts biofilm formation in a model sulfate reducing bacterium

Frontiers in Microbiology, 2014
We surveyed the eight putative cyclic-di-GMP-modulating response regulators (RRs) in Desulfovibrio vulgaris Hildenborough that are predicted to function via two-component signaling.
Lara eRajeev, Eric G Luning, Sara eAltenburg, Grant Matthew Zane, Edward E Baidoo, Michela eCatena, Jay D Keasling, Jay D Keasling, Judy D Wall, Matthew W Fields, Aindrila eMukhopadhyay   +10 more
doaj   +1 more source

Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]

, 2014
Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Caly, Delphine L., Joseph Ward (645977), Yvonne McCarthy (109070), Melanie Febrer (185470), Murdoch, Sarah L., Dow, J. Maxwell, Joseph Ward, Robert P. Ryan (108478), Ryan, Robert P., An, Shi Qi, An Shi-qi, Ryan Robert P., Shi-qi An, Robert P Ryan, J. Maxwell Dow (269095), J Maxwell Dow, McCarthy Yvonne, Caly Delphine L., Dow J. Maxwell, An, Shi-qi, Ward Joseph, Delphine L Caly, Yvonne McCarthy, McCarthy, Yvonne, Sarah L Murdoch, Melanie Febrer, Sarah L. Murdoch (645976), Ward, Joseph, Shi-qi An (5661025), Febrer Melanie, Febrer, Melanie, Delphine L. Caly (146386), Murdoch Sarah L.   +32 more
core   +1 more source

Identification of c-di-GMP Signaling Components in Xanthomonas oryzae and Their Orthologs in Xanthomonads Involved in Regulation of Bacterial Virulence Expression

Frontiers in Microbiology, 2019
Xanthomonas oryzae pv. oryzae (Xoo) causes bacterial leaf blight of rice, one of the most devastating bacterial diseases of this staple crop worldwide. Xoo produces a range of virulence-related factors to facilitate its pathogenesis in rice, however, the
Fenghuan Yang, Dingrong Xue, Fang Tian, William Hutchins, Ching-Hong Yang, Chenyang He   +5 more
doaj   +1 more source