Gas-Selective Catalytic Regulation by a Newly Identified Globin-Coupled Sensor Phosphodiesterase Containing an HD-GYP Domain from the Human Pathogen Vibrio fluvialis. [PDF]
BiochemistryGlobin-coupled sensors constitute an important family of heme-based gas sensors, an emerging class of heme proteins. In this study, we have identified and characterized a globin-coupled sensor phosphodiesterase containing an HD-GYP domain (GCS-HD-GYP) from the human pathogen Vibrio fluvialis, which is an emerging foodborne pathogen of increasing public
Kitanishi K, Aoyama N, Shimonaka M.
europepmc +3 more sources
Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris. [PDF]
Proc Natl Acad Sci U S A, 2010 RpfG is a paradigm for a class of widespread bacterial two-component regulators with a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris pv.
Ryan RP +5 more
europepmc +6 more sources
Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site. [PDF]
J Bacteriol, 2015 ABSTRACT The intracellular level of the bacterial secondary messenger cyclic di-3′,5′-GMP (c-di-GMP) is determined by a balance between its biosynthesis and degradation, the latter achieved via dedicated phosphodiesterases (PDEs) bearing a characteristic EAL or HD-GYP domain. We here report the crystal structure of PA4781, one of
Rinaldo S +9 more
europepmc +4 more sources
Genetic mapping of loci associated with yield and their components in black common bean (Phaseolus vulgaris L.). [PDF]
Plant GenomeAbstract The increase in world population linked to climate change leads to the need to develop more productive and more adapted cultivars of food species. Quantitative trait loci (QTLs) mapping is a useful tool although, interaction between genotype and the environment is still a challenge.
Reche DL +6 more
europepmc +2 more sources
Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales. [PDF]
Mol Plant PatholErwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Niroula D +3 more
europepmc +2 more sources
c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases. [PDF]
PLoS Genetics, 2011 Clostridium difficile infections have become a major healthcare concern in the last decade during which the emergence of new strains has underscored this bacterium's capacity to cause persistent epidemics.
Eric Bordeleau +3 more
doaj +1 more source
Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation
Frontiers in Chemistry, 2020 The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho +2 more
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Cyclic di‐GMP signaling—Where did you come from and where will you go?
Molecular Microbiology, Volume 120, Issue 4, Page 564-574, October 2023., 2023 Multilayer regulation by the diffusible molecule cyclic di‐GMP promotes coordinated association of bacterial cells into tissue‐like structures surrounded by protective extracellular substances. At low cyclic di‐GMP, those cells oppositely become motile/acutely virulent.
Ute Römling
wiley +1 more source
Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris. [PDF]
Molecular microbiology, 2013 RpfG is a member of a class of wide spread bacterial two-component regulators with an HD-GYP cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris, RpfG together with the sensor kinase RpfC regulates multiple factors as a response to the cell-to-cell Diffusible Signalling Factor (DSF).
Ryan, R +6 more
openaire +4 more sources
Retraction for Ryan et al., Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover. [PDF]
Proc Natl Acad Sci U S A, 2017 europepmc +4 more sources