The HD-GYP Domain, Cyclic Di-GMP Signaling, and Bacterial Virulence to Plants
Molecular Plant-Microbe Interactions, 2006 Cyclic di-GMP is an almost ubiquitous second messenger in bacteria that was first described as an allosteric activator of cellulose synthase but is now known to regulate a range of functions, including virulence in human and animal pathogens. Two protein
J. Maxwell Dow +3 more
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To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility. [PDF]
Mol MicrobiolMotility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Mohaghegh F, Scadden J, Baker MAB.
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Genetic mapping of loci associated with yield and their components in black common bean (Phaseolus vulgaris L.). [PDF]
Plant GenomeAbstract The increase in world population linked to climate change leads to the need to develop more productive and more adapted cultivars of food species. Quantitative trait loci (QTLs) mapping is a useful tool although, interaction between genotype and the environment is still a challenge.
Reche DL +6 more
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Proteomic Analysis of Three Independent Series of Sequential Cystic Fibrosis Strains in an International Pseudomonas aeruginosa Reference Panel Indicates Positive Selection in Late Infection Strains. [PDF]
MicrobiologyopenComparison of proteomes from three series of sequential Pseudomonas aeruginosa isolates from people with cystic fibrosis identified eleven proteins with increased abundance in at least one late isolate per patient. Three proteins were increased in all five late isolates, and the probability of this occurring by chance is 5.06 × 10−53, indicating strong
Drabinska J +3 more
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Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales. [PDF]
Mol Plant PatholErwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Niroula D +3 more
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Sequence Conservation, Domain Architectures, and Phylogenetic Distribution of the HD-GYP Type c-di-GMP Phosphodiesterases [PDF]
Journal of Bacteriology, 2022 Michael Y Galperín, Shan-Ho Chou
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HD-[HD-GYP] Phosphodiesterases: Activities and Evolutionary Diversification within the HD-GYP Family [PDF]
Biochemistry, 2020 Sining Sun, Maria-Eirini Pandelia
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A systematic analysis of the in vitro and in vivo functions of the HD-GYP domain proteins of Vibrio cholerae. [PDF]
BMC Microbiol, 2014 Background The second messenger cyclic diguanylate (c-di-GMP) plays a central role in bacterial adaptation to extracellular stimuli, controlling processes such as motility, biofilm development, cell development and, in some pathogens, virulence.
McKee RW +4 more
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Gas-Selective Catalytic Regulation by a Newly Identified Globin-Coupled Sensor Phosphodiesterase Containing an HD-GYP Domain from the Human Pathogen Vibrio fluvialis. [PDF]
BiochemistryGlobin-coupled sensors constitute an important family of heme-based gas sensors, an emerging class of heme proteins. In this study, we have identified and characterized a globin-coupled sensor phosphodiesterase containing an HD-GYP domain (GCS-HD-GYP ...
Kitanishi K, Aoyama N, Shimonaka M.
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Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site. [PDF]
J Bacteriol, 2015 The intracellular level of the bacterial secondary messenger cyclic di 3 amp; 8242;,5 amp; 8242; GMP c di GMP is determined by a balance between its biosynthesis and degradation, the latter achieved via dedicated phosphodiesterases PDEs bearing a ...
Rinaldo S +9 more
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