Results 21 to 30 of about 4,652 (199)

Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales. [PDF]

Mol Plant Pathol
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Niroula D, Bhandari K, Sundin GW, Joshi JR.   +3 more
europepmc   +2 more sources

Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity [PDF]

FEMS Microbiology Letters, 2001
A conserved domain, called GGDEF (referring to a conserved central sequence pattern), is detected in many procaryotic proteins, often in various combinations with putative sensory-regulatory components. Most sequenced bacterial genomes contain several different GGDEF proteins.
N, Ausmees, R, Mayer, H, Weinhouse, G, Volman, D, Amikam, M, Benziman, M, Lindberg   +6 more
openaire   +3 more sources

<i>Staphylococcus aureus</i> uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling. [PDF]

Proc Natl Acad Sci U S A
Staphylococcus aureus is a Gram-positive pathogen responsible for numerous antibiotic-resistant infections. Identifying vulnerabilities in S. aureus is crucial for developing new antibiotics to treat these infections.
Mychack A, Evans D, Gilles T, James MJ, Walker S.   +4 more
europepmc   +4 more sources

Role of the GGDEF protein family in Salmonella cellulose biosynthesis and biofilm formation [PDF]

Molecular Microbiology, 2004
Summary Salmonella enterica serovar Typhimurium is capable of producing cellulose as the main exopolysaccharide compound of the biofilm matrix. It has been shown for Gluconacetobacter xylinum that cellulose biosynthesis is allosterically regulated by bis‐(3′,5′) cyclic diguanylic acid, whose synthesis/degradation depends on diguanylate cyclase ...
García, Begoña, Latasa Osta, Cristina, Solano Goñi, Cristina, García del Portillo, Francisco, Gamazo de la Rasilla, Carlos, Lasa, Íñigo   +5 more
openaire   +3 more sources

Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus [PDF]

Molecular Microbiology, 2003
SummarySeveral members of the two‐component signal transduction family have been implicated in the control of  polar development in Caulobacter crescentus: PleC and DivJ, two polarly localized histidine sensor kinases; and the response regulators DivK and PleD.
Aldridge, P., Paul, R., Goymer, P., Rainey, P., Jenal, U.   +4 more
openaire   +3 more sources

Socializing, networking and development: a report from the second ‘Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis’ [PDF]

, 2012
In mid-June, the second Young Microbiologists Symposium took place under the broad title of ‘Microbe signalling, organization and pathogenesis’ on the picturesque campus of University College Cork, Ireland.
Barret, Brackman, Brown, Bush, Cascales, Corrigan, Costerton, Coulthurst, D'Autreaux, Davey, Delalez, Fazli, Gerlach, Hagan, Holland, Hood, Housden, Kleanthous, Kuchma, Kuchma, Kuchma, Lawley, Lebeer, Malone, McCarthy, Merritt, Murdoch, O'Connell Motherway, O'Connell Motherway, O'Toole, Porter, Ramsay, Ramsay, Rigel, Roberts, Ryan, Ryan, Ryan, Ryan, Ryan, Schwarz, Sharma, Shioya, Smith, Thompson, Twomey, Waters, Yang, Youle   +48 more
core   +1 more source

Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]

, 2015
The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel, Aldridge, Amikam, Aragón, Barahona, Baraquet, Bell, Benach, Bingle, Boehm, Boyd, Brencic, Christen, Clare E.M. Stevenson, Compant, Cuppels, David M. Lawson, De, Duerig, Eleftheria Trampari, Emsley, Engl, Fazli, Gal, Galibert, Gledhill, Haas, Hengge, Hickman, Ho, Hughes, Iino, Imada, Jacob G. Malone, Jonas, Kelley, Krasteva, Krissinel, Kuchma, Kuchma, Kulasakara, Lee, Lindeberg, Little, Lovering, Lucchini, Lugtenberg, Macnab, Macnab, Martínez-Granero, Matilla, McNicholas, Miller, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Moscoso, Moscoso, Naseby, Navazo, Nesper, Newell, Newell, Pfeilmeier, Pultz, Pérez-Mendoza, Qi, Rainey, Richard H. Little, Roelofs, Ryan, Schirmer, Solano, Srivastava, Starkey, Steiner, Story, Sudarsan, Tchigvintsev, Thomas Wilhelm, Tschowri, Wassmann, Wilhelm, Woodcock, Xin   +89 more
core   +1 more source

Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae

BMC Microbiology, 2012
Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections.
Cruz Diana P, Huertas Mónica G, Lozano Marcela, Zárate Lina, Zambrano María   +4 more
doaj   +1 more source

Modulation of biofilm-formation in Salmonella enterica serovar Typhimurium by the periplasmic DsbA/DsbB oxidoreductase system requires the GGDEF-EAL domain protein STM3615. [PDF]

PLoS ONE, 2014
In Salmonella enterica serovar Typhimurium (S. Typhimurium), biofilm-formation is controlled by the cytoplasmic intracellular small-molecular second messenger cyclic 3', 5'-di- guanosine monophosphate (c-di-GMP) through the activities of GGDEF and EAL ...
Naeem Anwar, Syed Fazle Rouf, Ute Römling, Mikael Rhen   +3 more
doaj   +1 more source

Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]

, 2014
Bis-(3 ',5 ') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence.
A Teplyakov, C Momany, C Saveanu, CD Boyd, CR Guzzo, D-G Ha, David Mackey, Delphine L. Caly, F Tao, GG Anderson, H Mulcahy, H Slater, H Sondermann, IS Pultz, J Duevel, J Mansfield, J Nesper, J. Maxwell Dow, Joseph Ward, K-H Chin, KB Twomey, Melanie Febrer, MY Galperin, R Hengge, Robert P. Ryan, RP Ryan, RP Ryan, RP Ryan, RP Ryan, RP Ryan, RP Ryan, S Moreau-Marquis, S-Q An, S-Q An, S-Q An, Sarah L. Murdoch, SE Maddocks, Shi-qi An, T Lundback, T Schirmer, U Romling, X Qiao, X-H Lu, Y Fouhy, Y McCarthy, Y McCarthy, Yvonne McCarthy   +46 more
core   +5 more sources