Modulation of biofilm-formation in Salmonella enterica serovar Typhimurium by the periplasmic DsbA/DsbB oxidoreductase system requires the GGDEF-EAL domain protein STM3615. [PDF]
PLoS ONE, 2014 In Salmonella enterica serovar Typhimurium (S. Typhimurium), biofilm-formation is controlled by the cytoplasmic intracellular small-molecular second messenger cyclic 3', 5'-di- guanosine monophosphate (c-di-GMP) through the activities of GGDEF and EAL ...
Naeem Anwar +3 more
doaj +1 more source
Microbiology Spectrum, 2023 Colony pattern formations of bacteria with motility manifest complicated morphological self-organization phenomena. Leptolyngbya boryana is a filamentous cyanobacterium, which has been used as a genetic model organism for studying metabolism including ...
Kazuma Toida +10 more
doaj +1 more source
GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP
npj Biofilms and Microbiomes, 2022 In bacteria, the monopolar localization of enzymes and protein complexes can result in a bimodal distribution of enzyme activity between the dividing cells and heterogeneity of cellular behaviors.
Tim Rick +12 more
doaj +1 more source
Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]
, 2012 In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core +1 more source
Comparative analysis of diguanylate cyclase and phosphodiesterase genes in
BMC Microbiology, 2012 Background Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections.
Cruz Diana P +4 more
doaj +1 more source
eLife, 2019 A newfound signaling pathway employs a GGDEF enzyme with unique activity compared to the majority of homologs associated with bacterial cyclic di-GMP signaling.
Zachary F Hallberg +7 more
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Molecular Plant-Microbe Interactions, 2014 Degenerate GGDEF and EAL domain proteins represent major types of cyclic diguanylic acid (c-di-GMP) receptors in pathogenic bacteria. Here, we characterized a FimX-like protein (Filp) which possesses both GGDEF and EAL domains in Xanthomonas oryzae pv ...
Fenghuan Yang +7 more
doaj +1 more source
Characterization of the Xylella fastidiosa PD1671 gene encoding degenerate c-di-GMP GGDEF/EAL domains, and its role in the development of Pierce's disease. [PDF]
PLoS ONE, 2015 Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce's disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of ...
Luciana Cursino +9 more
doaj +1 more source
Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control [PDF]
, 2014 When Caulobacter crescentus enters S-phase the replication initiation inhibitor CtrA dynamically positions to the old cell pole to be degraded by the polar ClpXP protease.
Ebbensgaard, Anna Elisabeth +7 more
core +1 more source
Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3���, 3���-cGAMP) [PDF]
, 2016 Over 30 years ago, GGDEF domain-containing enzymes were shown to be diguanylate cyclases that produce cyclic di-GMP (cdiG), a second messenger that modulates the key bacterial lifestyle transition from a motile to sessile biofilm-forming state.
Hammond, Ming C +19 more
core +1 more source