Results 11 to 20 of about 3,043 (159)

PafS Containing GGDEF-Domain Regulates Life Activities of Pseudomonas glycinae MS82

Microorganisms, 2022
Cyclic dimeric guanosine monophosphate (c-di-GMP) is synthesized by diguanylate cyclase (DGC) with the GGDEF domain. As a ubiquitous bacterial second messenger, it regulates diverse life-activity phenotypes in some bacteria.
Xianyi Chen, Shaoxuan Qu, Xin Luo, Shi-En Lu, Youzhou Liu, Huiping Li, Lijuan Hou, Jinsheng Lin, Ning Jiang, Lin Ma   +9 more
doaj   +2 more sources

Systematic Analysis of Two Tandem GGDEF/EAL Domain Genes Regulating Antifungal Activities in Pseudomonas glycinae MS82

Horticulturae, 2023
Cyclic diguanylate (c-di-GMP) affects bacterial physiological and biochemical functions like biofilm, motility, virulence, and bacterial secretion systems. GGDEF/EAL-domain proteins, participating in c-di-GMP synthesis and degradation, are widely present
Jinsheng Lin, Shaoxuan Qu, Xianyi Chen, Huiping Li, Lijuan Hou, Shi-En Lu, Ping Xu, Ning Jiang, Lin Ma   +8 more
doaj   +2 more sources

Production of 3',3'-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility. [PDF]

PLoS Genetics, 2022
Bacterial second messengers are important for regulating diverse bacterial lifestyles. Cyclic di-GMP (c-di-GMP) is produced by diguanylate cyclase enzymes, named GGDEF proteins, which are widespread across bacteria.
Rebecca C Lowry, Zachary F Hallberg, Rob Till, Tyler J Simons, Ruth Nottingham, Fiona Want, R Elizabeth Sockett, Ming C Hammond, Carey Lambert   +8 more
doaj   +2 more sources

Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase [PDF]

Nature Communications, 2021
As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely ...
Raphael D. Teixeira, Fabian Holzschuh, Tilman Schirmer   +2 more
doaj   +2 more sources

Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation. [PDF]

Protein Sci
Abstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Fuchs M, Winkler A.
europepmc   +2 more sources

Patterns of abundance, chromosomal localization, and domain organization among c-di-GMP-metabolizing genes revealed by comparative genomics of five alphaproteobacterial orders

BMC Genomics, 2022
Background Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a bacterial second messenger that affects diverse processes in different bacteria, including the cell cycle, motility, and biofilm formation.
Sonja Koppenhöfer, Andrew S. Lang
doaj   +1 more source

Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate

Nature Communications, 2023
Previous studies have demonstrated that bis-(3',5')-cyclic diguanosine monophosphate (bis-3',5'-c-di-GMP) is a ubiquitous second messenger employed by bacteria. Here, we report that 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) controls the important
Xia Li, Wenfang Yin, Junjie Desmond Lin, Yong Zhang, Quan Guo, Gerun Wang, Xiayu Chen, Binbin Cui, Mingfang Wang, Min Chen, Peng Li, Ya-Wen He, Wei Qian, Haibin Luo, Lian-Hui Zhang, Xue-Wei Liu, Shihao Song, Yinyue Deng   +17 more
doaj   +1 more source

Comparative Genomic Analysis Identifies FleQ and GcbB as Virulence-Associated Factors in Pseudomonas syringae pv. tabaci Strains. [PDF]

Mol Plant Pathol
Comparative genomic analysis between highly virulent strain Pta6605 and less virulent strain Pta7375 showed that point mutations in fleQ and gcbB are responsible for the contrasting virulence‐related phenotypes between the two strains. ABSTRACT Pseudomonas syringae pv.
Hidayat MT, Yoshioka K, Nishimura T, Asai S, Masuda S, Shirasu K, Sakata N, Yamamoto M, Noutoshi Y, Toyoda K, Ichinose Y, Matsui H.   +11 more
europepmc   +2 more sources

CdgB GGDEF domain structure.

, 2022
(A) Sequence alignment between CdgB GGDEF domain from A. baldaniorum Sp245 (GenBank access number CCD03171.1) and other GGDEF domains of known structure. PleD, C. crescentus (GenBank access number YP_002517919.1), and RbdA, P.
Sandra R. Reyes-Carmona (14165033), Víctor I. Viruega-Góngora (14165027), Alberto Ramírez-Mata (6336152), María L. Xiqui-Vázquez (14165036), David Zamorano-Sánchez (8582430), Iris S. Acatitla-Jácome (14165030), Beatriz Eugenia Baca (6336146)   +6 more
core   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales. [PDF]

Mol Plant Pathol
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Niroula D, Bhandari K, Sundin GW, Joshi JR.   +3 more
europepmc   +2 more sources