Results 11 to 20 of about 4,652 (199)
Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate [PDF]
Open Biology, 2013 Complex 3′-5′-cyclic diguanylic acid (c-di-GMP) responsive regulatory networks that are modulated by the action of multiple diguanylate cyclases (DGC; GGDEF domain proteins) and phosphodiesterases (PDE; EAL domain proteins) have evolved in many bacteria.
Melissa Lacey +3 more
doaj +4 more sources
Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase [PDF]
Nature Communications, 2021 As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely ...
Raphael D. Teixeira +2 more
doaj +7 more sources
GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP
npj Biofilms and Microbiomes, 2022 In bacteria, the monopolar localization of enzymes and protein complexes can result in a bimodal distribution of enzyme activity between the dividing cells and heterogeneity of cellular behaviors.
Tim Rick +12 more
doaj +6 more sources
Microbiology Spectrum, 2023 Colony pattern formations of bacteria with motility manifest complicated morphological self-organization phenomena. Leptolyngbya boryana is a filamentous cyanobacterium, which has been used as a genetic model organism for studying metabolism including ...
Kazuma Toida +10 more
doaj +3 more sources
Horticulturae, 2023 Cyclic diguanylate (c-di-GMP) affects bacterial physiological and biochemical functions like biofilm, motility, virulence, and bacterial secretion systems. GGDEF/EAL-domain proteins, participating in c-di-GMP synthesis and degradation, are widely present
Jinsheng Lin +8 more
doaj +2 more sources
eLife, 2019 A newfound signaling pathway employs a GGDEF enzyme with unique activity compared to the majority of homologs associated with bacterial cyclic di-GMP signaling.
Zachary F Hallberg +7 more
doaj +3 more sources
In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes [PDF]
BMC Microbiology, 2018 Background The cyclic-di-GMP (c-di-GMP) second messenger exemplifies a signaling system that regulates many bacterial behaviors of key importance; among them, c-di-GMP controls the transition between motile and sessile life-styles in bacteria. Cellular c-
Alberto Ramírez Mata +4 more
doaj +3 more sources
Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1. [PDF]
PLoS ONE, 2015 Bacterial invasion plays a critical role in the establishment of Pseudomonas aeruginosa infection and is aided by two major virulence factors--surface appendages and secreted proteases.
Ayshwarya Ravichandran +4 more
doaj +8 more sources
New Functions and Subcellular Localization Patterns of c-di-GMP Components (GGDEF Domain Proteins) in B. subtilis [PDF]
Frontiers in Microbiology, 2017 The universal and pleiotropic cyclic dinucleotide second messenger c-di-GMP is most prominently known to inversely regulate planktonic and sessile lifestyles of Gram-negative species. In the Gram-positive model organism Bacillus subtilis, intracellular c-
Patricia Bedrunka, Peter L. Graumann
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Comparative Genomic Analysis Identifies FleQ and GcbB as Virulence-Associated Factors in Pseudomonas syringae pv. tabaci Strains. [PDF]
Mol Plant PatholComparative genomic analysis between highly virulent strain Pta6605 and less virulent strain Pta7375 showed that point mutations in fleQ and gcbB are responsible for the contrasting virulence‐related phenotypes between the two strains. ABSTRACT Pseudomonas syringae pv.
Hidayat MT +11 more
europepmc +2 more sources