British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind +6 more
wiley +1 more source
Poultry ScienceThrough the selective breeding of superior strains, livestock and poultry can achieve enhanced disease resistance and production performance, thereby improving farming efficiency and increasing chicken meat yield.
Shifan Deng +7 more
doaj +1 more source
Scientific Reports, 2023 Disordered sleep is a global social problem and an established significant risk factor for psychological and metabolic diseases. We profiled non-targeted metabolites in saliva from mouse models of chronic sleep disorder (CSD).
Katsutaka Oishi +6 more
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The synthesis and structural characterization of graft copolymers composed of γ-PGA backbone and oligoesters pendant chains [PDF]
, 2017 © 2017 The Authors. Published by American Chemical Society. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1021/jasms ...
Adamus, Grażyna +5 more
core +2 more sources
The Use of Computed Tomography in the Study of Microstructure of Molded Pieces Made of Poly(3-hydroxybutyric-co-3-hydroxyvaleric acid) (PHBV) Biocomposites with Natural Fiber [PDF]
, 2021 Wiesław Frącz +3 more
openalex +1 more source
Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion
Epilepsia, EarlyView.Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi +7 more
wiley +1 more source
γ-Aminobutyric AcidB(GABAB)-Receptor Mediation of Different In Vivo Effects of γ-Butyrolactone
Journal of Pharmacological Sciences, 2008 The endogenous brain constituent, γ-hydroxybutyric acid (GHB), as well as its prodrug, γ-butyrolactone (GBL), have recently gained interest in the drug addiction field due to their abuse potential and fatalities caused by overdose.
Mauro A.M. Carai +5 more
doaj +1 more source
Pharmacokinetics and Excretion of Gamma-Hydroxybutyrate (GHB) in Healthy Subjects [PDF]
, 2017 In Europe and the United States, the recreational use of gammahydroxy butyric acid (GHB) at dance clubs and "rave” parties has increased substantially. In addition, GHB is used to assist in the commission of sexual assaults.
Brenneisen, Rudolf +6 more
core
PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]
, 2019 Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G +10 more
core +2 more sources
Unraveling A‐β+ ketosis‐prone diabetes: An evolving diagnosis with an elusive pathogenesis
Journal of Diabetes Investigation, EarlyView.ABSTRACT Since the discovery of insulin over a century ago, how we conceptualize, describe and treat diabetes has evolved, paving the way for the identification of distinct diabetes subgroups and individualized treatment options. Historically, the term ketosis‐prone diabetes (KPD) has comprised a group of diabetes syndromes characterized by severe ...
Nina Suda +3 more
wiley +1 more source