Results 81 to 90 of about 480,266 (218)

Identification of Serum-Based Metabolic Feature and Characteristic Metabolites in Paraquat Intoxicated Mouse Models

Frontiers in Physiology, 2020
Paraquat (PQ) is a widely used herbicide which can cause high mortality to humans. However, relatively few studies focus on metabolic feature of PQ intoxication for investigating the underlying mechanisms.
Youjia Yu, Zishan Gao, Jiaqian Lou, Zhengsheng Mao, Kai Li, Chunyan Chu, Li Hu, Zheng Li, Chuwei Deng, Hanting Fan, Peng Chen, Huijie Huang, Yanfang Yu, Jingjing Ding, Ding Li, Feng Chen, Feng Chen   +16 more
doaj   +1 more source

Metabolic Reprogramming of a Phenolic Acid by a Plant P450 Monooxygenase Reverses Bacterial Immunosuppression

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4672-4688, July 2026.
Ralstonia solanacearum suppresses P450 activity to block VA‐to‐VanA conversion, leading to VA accumulation and compromised immunity. ABSTRACT Soil acidification often exacerbates plant diseases caused by soil‐borne pathogens like Ralstonia solanacearum, but the underlying molecular mechanisms remain elusive. This study unveils a sophisticated metabolic
Hua Wang, Xiaoshuang Peng, Xinrui Wang, Ruiyu Yang, Tao Liu, Huidi Liu, Chao Zhao, Hong Zhou, Liang Yang, Shili Li, Wei Ding   +10 more
wiley   +1 more source

Poly (vinyl alcohol) Microspheres Sandwiched Poly (3-hydroxybutyric acid) Electrospun Fibrous Scaffold for Tissue Engineering and Drug Delivery

, 2014
Three drug delivery systems viz. doxycycline hyclate entrapped poly (vinyl alcohol) (PVA) microspheres (DM), composite fibers of doxycycline hyclatepoly (3-hydroxybutyric acid) (PHB) electrospun fibers (DF), and doxycycline hyclateloaded poly (vinyl ...
Liji Sobhana (537829), Giriprasath Ramanathan (537828), Uma Tirichurapalli Sivagnanam (537830), Natarajan Tirupattur Srinivasan (537831), Naveen Nagiah (537827)   +4 more
core   +1 more source

The Chronic Intermittent Form of Isovaleric Acidemia With Staphylococcal Scalded Skin Syndrome: A Case Report and Literature Review

Journal of Pediatrics Review, 2020
Isovaleric Acidemia (IVA) is an autosomal recessive Inborne Error of Metabolism (IEM), i.e., caused by the mutation of isovaleric-CoA dehydrogenase. Two phenotypes of IVA are reported; acute and chronic.
Daniel Zamanfar, Elham Keyhanian, Mobin Ghazaiean, Somayeh Rostami Maskopaii   +3 more
doaj  

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, Volume 604, Issue 13, Page 5391-5420, 1 July 2026.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid

, 2003
Two gamma-hydroxybutyric acid (GHB) analogues, trans-gamma-hydroxycrotonic acid (t-HCA) and gamma-(p-methoxybenzyl)-gamma-hydroxybutyric acid (NCS-435) displaced [H-3]GHB from GHB receptors with the same affinity as GHB but, unlike GHB, failed to ...
CIGNARELLA G., MOCCI I., TANGANELLI S., CASTELLI, MARIA PAOLA, CARTA F., FERRARO L., ANTONELLI T., CARAI M. A. M., GESSA G. L. .   +8 more
core   +1 more source

Enantioselective Microbial Reduction with Baker's Yeast on an Industrial Scale

CHIMIA, 2000
Microbial synthesis is an important contribution to Green Chemistry and production-integrated environmental protection. The example of baker's yeast is used to demonstrate how microorganisms can be versatile reagents for asymmetric synthesis and
Martin Bertau, Martin Bürli
doaj   +2 more sources

Klebsiella sp. strain B7 enhances alkaline tolerance by secreting pyruvic acid to accelerate L‐malic acid accumulation in soybean

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1727-1743, June 2026.
Klebsiella sp. strain B7 acts as a positive regulator in alkaline stress responses in soybean. By activating pyruvic acid metabolism and L‐malic acid biosynthesis pathways, B7 significantly increases alkaline tolerance and yield in soybean. ABSTRACT Alkaline stress is a major constraint on crop growth and development and negatively impacts soybean ...
Yingxue Cao, Yijia Jiang, Yang Li, Yong Long, Siyu Huang, Hongwei Li, Miao Yang, Mingyu Yang, Yuecheng Tang, Bo Zhang, Zhongming Fang, Ming Yuan, Zhenhua Yu, Fanli Meng   +13 more
wiley   +1 more source

In vivo assessment of parenteral formulations of oligo(3-hydroxybutyric acid) conjugates with the model compound ibuprofen

, 2010
Polymer-drug conjugates have gained significant attention as pro-drugs releasing an active substance as a result of enzymatic hydrolysis in physiological environment.
Carsten Ehrhardt, Pawel Grieb, Maria Luczyk-Juzwa, EHRHARDT, CARSTEN, Malgorzata Sznitowska, Pawel Stasiak   +5 more
core   +1 more source