Results 31 to 40 of about 480,266 (218)

Metabolomic effects of androgen deprivation therapy treatment for prostate cancer

Cancer Medicine, 2020
Androgen deprivation therapy (ADT) is the main treatment strategy for men with metastatic prostate cancer (PC). However, ADT is associated with various metabolic disturbances, including impaired glucose tolerance, insulin resistance and weight gain ...
Jen‐Tsan Chi, Pao‐Hwa Lin, Vladimir Tolstikov, Taofik Oyekunle, Emily Y. Chen, Valerie Bussberg, Bennett Greenwood, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish, Stephen J. Freedland   +10 more
doaj   +1 more source

Metabolomic Profiling of Bipolar Disorder by ¹H-NMR in Serbian Patients

Metabolites, 2023
Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden.
Katarina Simić, Zoran Miladinović, Nina Todorović, Snežana Trifunović, Nataša Avramović, Aleksandra Gavrilović, Silvana Jovanović, Dejan Gođevac, Ljubodrag Vujisić, Vele Tešević, Ljubica Tasic, Boris Mandić   +11 more
doaj   +1 more source

(2S,3R)-2-[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonylamino]-3-hydroxybutyric acid monohydrate

Acta Crystallographica Section E, 2008
In the title compound, C11H17N3O6·H2O, an important building block of the medicine cefbuperazone sodium, the piperazine ring adopts a screw-boat conformation. Intermolecular O—H...O and intramolecular N—H...O hydrogen bonds are observed.
Chun-xiang Ji, Yong-tao Cui, Dong-ling Yang, Cheng Guo   +3 more
doaj   +1 more source

A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces

, 2002
The occurrence of poly-3-hydroxybutyric acid (PHB) in 12 different strains of the genusStreptomyces was investigated. Gas chromatographic estimation indicated that all the strains produced PHB and the range of maximum PHB accumulation was between 1.5 and
Verma, S., Bhatia, Y., Roy, I., Valappil, S.P.   +3 more
core   +1 more source

Highly Diastereoselective Construction of Carbon– Heteroatom Quaternary Stereogenic Centers in the Synthesis of Analogs of Bioactive Compounds: From Monofluorinated Epoxyalkylphosphonates to α-Fluoro-, β-, or γ-Amino Alcohol Derivatives of Alkylphosphonates

Frontiers in Chemistry, 2021
The synthesis of the stable surrogates of an important amino acid (R)-4-amino-3-hydroxybutyric acid (GABOB) such as substituted hydroxy aminophosphonic acids bearing a quaternary stereogenic center is presented.
Magdalena Rapp, Klaudia Margas-Musielak, Patrycja Kaczmarek, Agnieszka Witkowska, Tomasz Cytlak, Tomasz Cytlak, Tomasz Siodła, Henryk Koroniak   +7 more
doaj   +1 more source

Glucose related endocrine and metabolic responses following bolus intravenous hypertonic dextrose administration in Iranian fat-tailed ewes at different pre and post parturition periods [PDF]

Bulgarian Journal of Veterinary Medicine, 2020
Providing glucose as primary metabolic fuel for maintenance, foetal growth and milk production may be considered necessary for protection against negative energy balance and metabolic disorders.
A. Chalmeh, A. Merzaei, M. Pourjafar, K. Badiei, M. Mazrouei Sebdani, I. Saadat Akhtar , M. Hadi Zarei   +6 more
doaj   +1 more source

Ulva rigida Valorization into Poly(3-hydroxybutyrate), Organic Acids and Functional Ingredients

Marine Drugs, 2023
Halomonas elongata 1H9T is a moderate halophilic strain able to produce poly(3-hydroxybutyrate) (P(3HB)), a biodegradable plastic, and gluconic acid, a valuable organic acid with wide industrial applications. In this work, the green alga Ulva rigida was used as platform to produce cultivation substrates for microbial conversion as well as functional ...
Tânia Leandro, Marco Teles, Joana S. Gomes-Dias, Mafalda Marques, Cristina M. R. Rocha, M. Manuela R. da Fonseca, M. Teresa Cesário   +6 more
openaire   +4 more sources

Why Do High-Risk Patients Develop or Not Develop Coronary Artery Disease? Metabolic Insights from the CAPIRE Study

Metabolites, 2022
Traditional cardiovascular (CV) risk factors (RFs) and coronary artery disease (CAD) do not always show a direct correlation. We investigated the metabolic differences in a cohort of patients with a high CV risk profile who developed, or did not develop,
Martino Deidda, Antonio Noto, Christian Cadeddu Dessalvi, Daniele Andreini, Felicita Andreotti, Eleuterio Ferrannini, Roberto Latini, Aldo P. Maggioni, Marco Magnoni, Giuseppe Mercuro, on behalf of the CAPIRE Investigators   +10 more
doaj   +1 more source

The metabolic effects of intermittent versus continuous feeding in critically ill patients

Scientific Reports, 2023
Intermittent (or bolus) feeding regimens in critically ill patients have been of increasing interest to clinicians and scientists. Changes in amino acid, fat and carbohydrate metabolites over time might yet deliver other benefits (e.g.
D. Wilkinson, I. J. Gallagher, A. McNelly, D. E. Bear, N. Hart, H. E. Montgomery, A. Le Guennec, M. R. Conte, T. Francis, S. D. R. Harridge, P. J. Atherton, Z. A. Puthucheary   +11 more
doaj   +1 more source

Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain [PDF]

, 2001
2-Hydroxybutyric acid appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral"
Wyse, A.T.S., A.R. Silva, Dutra-Filho, C.S., M. Wajner, A.T.S. Wyse, C.M.D. Wannmacher, Wajner, M., C. Ruschel, C.S. Dutra-Filho, Ruschel, C., C. Helegda, Helegda, C., Wannmacher, C.M.D., Silva, A.R.   +13 more
core   +3 more sources