Results 11 to 20 of about 1,374,074 (257)

Development of a semi-endogenous PRT-based expression system for Methylotuvimicrobium alcaliphilum and its application to enhance 3-hydroxybutyric acid production from methanol [PDF]

Journal of Biological Engineering
Background Endogenous expression systems, such as those incorporating promoters, ribosome-binding sites (RBS), and terminators (i.e., PRT systems), have been developed for various bacterial host strains.
Khoi Nhat Pham, Eun Yeol Lee
doaj   +2 more sources

Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study [PDF]

Cardiovascular Diabetology
Background No previous studies have explored metabolites associated with both genetic predispositions to type 2 diabetes (T2DM) and T2DM onset. Therefore, we aimed to explore metabolic profiles using genetic risk to identify pathways for tailored T2DM ...
Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Seizo Koshiba, Kazuki Kumada, Ikuko Motoike, Eiji Hishinuma, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N. Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kinuko Ohneda, Kengo Kinoshita, Atsushi Hozawa, Masayuki Yamamoto, Biobank Japan Project, the ToMMo investigators   +36 more
doaj   +2 more sources

Enhanced production of D-(-)-3-hydroxybutyric acid by recombinant Escherichia coli. [PDF]

FEMS Microbiology Letters, 2002
Wild-type bacteria including Escherichia coli normally do not produce extracellular D-(-)-3-hydroxybutyric acid (3HB). To produce extracellular chiral 3HB, a new pathway for synthesis of 3HB was constructed by simultaneous expression of genes of beta-ketothiolase (phbA), acetoacetyl-CoA reductase (phbB), phosphor-transbutyrylase (ptb) and butyrate ...
Haijun Gao, Qiong Wu, Guoqiang Chen
semanticscholar   +3 more sources

Molecular characterization, clinical phenotype, and neurological outcome of twelve Palestinian children with beta-ketothiolase deficiency: report of two novel variants in the ACAT1 gene [PDF]

BMC Medical Genomics
Background Beta-ketothiolase deficiency (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency (OMIM #203750, *607809) is an autosomal recessive disorder of isoleucine catabolism and ketone body utilization.
Imad M. Dweikat, Hamza A. Abdul-Hafez, Alaa Zayed, Moien Kanaan, Hanin Kasem, Rami Bzour   +5 more
doaj   +2 more sources

𝜷-hydroxybutyric acid attenuates oxidative stress and improves markers of mitochondrial function in the HT-22 hippocampal cell line [PDF]

Journal of Integrative Neuroscience, 2021
Ketone bodies have been the topic of research for their possible therapeutic neurotropic effects in various neurological diseases such as Parkinson’s disease, dementia, and seizures.
Mohammed Majrashi, Mansour Altukri, Sindhu Ramesh, Manoj Govindarajulu, Jack Schwartz, Mohammed Almaghrabi, Forrest Smith, Tony Thomas, Vishnu Suppiramaniam, Timothy Moore, Miranda Reed, Muralikrishnan Dhanasekaran   +11 more
doaj   +1 more source

Serum Metabolomic Study on the Difference between Mild and Severe Acute Pancreatitis Based on Liquid Chromatography-tandem Mass Spectrometry [PDF]

Zhongguo quanke yixue, 2023
Background Mild acute pancreatitis (MAP) has a certain probability of transforming into severe acute pancreatitis (SAP) . Once SAP occurs, it will cause greater harm to patients. It is meaningful for diagnosis and treatment of pancreatitis to explore the
HUANG Xiangping, WU Ling, TAN Chaochao
doaj   +1 more source

Acid-tolerant poly(3-hydroxybutyrate) hydrolases from moulds [PDF]

FEMS Microbiology Letters, 1988
We have isolated some mould strains that can grow under acid conditions with poly(3-hydroxybutyrate) (PHB) as sole carbon source, and secrete PHB hydrolases active at pH values at least down to 3. An improved assay method for such enzymes using a pH stat has been developed, and used to determine the dependence of reaction rate on enzyme and polymer ...
Douglas W. McLellan, Peter J. Halling
openaire   +2 more sources

Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat

Toxics, 2023
Diquat (DQ), a widely used bipyridyl herbicide, is associated with significantly higher rates of kidney injuries compared to other pesticides. However, the underlying molecular mechanisms are largely unknown.
Huazhong Zhang, Jinsong Zhang, Jinquan Li, Zhengsheng Mao, Jian Qian, Cheng Zong, Hao Sun, Beilei Yuan   +7 more
doaj   +1 more source

Production of (R)-3-hydroxybutyric acid from methane by in vivo depolymerization of polyhydroxybutyrate in Methylocystis parvus OBBP.

Bioresource Technology, 2022
Methylocystis parvus OBBP accumulates polyhydroxybutyrate (PHB) using methane as the sole carbon and energy source. In this work, the feasibility of producing (R)-3-hydroxybutyric acid (R3HBA) via intracellularly accumulated PHB through depolymerization (
Luz Yáñez, Yadira Rodríguez, Felipe Scott, A. Vergara‐Fernández, Raúl Muñoz   +4 more
semanticscholar   +1 more source

Targeted and untargeted metabolomic approach for GDM diagnosis

Frontiers in Molecular Biosciences, 2023
Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and is mainly connected with glucose metabolism.
Izabela Burzynska-Pedziwiatr, Danuta Dudzik, Anna Sansone, Beata Malachowska, Beata Malachowska, Beata Malachowska, Beata Malachowska, Andrzej Zieleniak, Monika Zurawska-Klis, Carla Ferreri, Chryssostomos Chatgilialoglu, Katarzyna Cypryk, Lucyna A. Wozniak, Michal J. Markuszewski, Malgorzata Bukowiecka-Matusiak   +14 more
doaj   +1 more source