Results 11 to 20 of about 480,266 (218)

Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet. [PDF]

Int J Mol Sci, 2021
BACKGROUND: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory properties; however, the effect ...
Shrestha N, Melvin SD, McKeating DR, Holland OJ, Cuffe JSM, Perkins AV, McAinch AJ, Hryciw DH.   +7 more
europepmc   +2 more sources

Characterisation of a novel conjugate of ibuprofen with 3-hydroxybutyric acid oligomers

Journal of Pharmacy and Pharmacology, 2009
Abstract Objectives A conjugate of ibuprofen with 3-hydroxybutyric acid oligomers has been evaluated as a novel drug delivery model system. Methods This paper focuses on the synthesis and the characterisation of the physicochemical ...
Pawel, Stasiak, Carsten, Ehrhardt, Maria, Juzwa, Malgorzata, Sznitowska   +3 more
openaire   +3 more sources

Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) based tissue engineering matrices

Journal of Materials Science: Materials in Medicine, 2003
In this study, the aim was to produce tissue-engineered bone using osteoblasts and a novel matrix material, poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV). In order to prepare a porous PHBV matrix with uniform pore size, sucrose crystals were loaded in the foam and then leached leaving pores behind.
Gamze Torun, Köse, Suzan, Ber, Feza, Korkusuz, Vasif, Hasirci   +3 more
core   +4 more sources

Novel Enzymatic Synthesis of 3-hydroxybutyric Acid Oligomerswith Inserted Lactobionic Acid Moieties

, 2011
3-Hydroxybutyric acid and lactobionic acid yielded linear and cyclic oligomers in a lipase-catalyzedcondensation polymerization reaction, performed at 80°C in bulk and organic solvent systems. Novozyme435 was the most efficient biocatalyst, and a mixture of t-butanol and dimethylsulfoxide in 80:20 (v/v) ratioprovided the highest copolymer conversions ...
Kakasi-Zsurka, S., Todea, A., But, A., Paul, C., Boeriu, C.G., Nagv, A., Davidescu, C.M., Peter, F.   +7 more
openaire   +2 more sources

Targeted and untargeted metabolomic approach for GDM diagnosis

Frontiers in Molecular Biosciences, 2023
Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and is mainly connected with glucose metabolism.
Izabela Burzynska-Pedziwiatr, Danuta Dudzik, Anna Sansone, Beata Malachowska, Beata Malachowska, Beata Malachowska, Beata Malachowska, Andrzej Zieleniak, Monika Zurawska-Klis, Carla Ferreri, Chryssostomos Chatgilialoglu, Katarzyna Cypryk, Lucyna A. Wozniak, Michal J. Markuszewski, Malgorzata Bukowiecka-Matusiak   +14 more
doaj   +1 more source

Identification of Morphine and Heroin-Treatment in Mice Using Metabonomics

Metabolites, 2021
Although heroin and morphine are structural analogues and morphine is a metabolite of heroin, it is not known how the effect of each substance on metabolites in vivo differs. Heroin and morphine were administered to C57BL/6J mice in increasing doses from
Wuhuan Lu, Ran Zhang, Wei Sheng, Luohua Feng, Peng Xu, Youmei Wang, Yuan Xie, Hui Xu, Guangji Wang, Jiye Aa   +9 more
doaj   +1 more source

A New Antimicrobial Agent: Poly (3‐hydroxybutyric acid) Oligomer [PDF]

Macromolecular Bioscience, 2019
AbstractIn this work, it is first reported that the poly (3‐hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one‐step ring‐opening polymerization of β‐butyrolactone and extraction from the fermented ...
Linlin Ma, Ziheng Zhang, Jun Li, Xingxing Yang, Bin Fei, Polly H. M. Leung, Xiaoming Tao   +6 more
openaire   +3 more sources

Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer. [PDF]

Cancer Med
This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Zainurin NAA, Bambarandhage AUKH, Escalona MM, Ivanova D, Gate T, Tench H, Beckman M, Phillips H, Pennick M, Mur LAJ.   +9 more
europepmc   +2 more sources

The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders

Frontiers in Psychiatry, 2020
BackgroundAutism spectrum disorder (ASD) is a type of neurodevelopmental disease that is frequently accompanied by sleep disorder. Herein, we investigated changes in the gut microbiota and its metabolites correlated with core symptoms and sleep problems ...
Xueying Hua, Xueying Hua, Jiang Zhu, Jiang Zhu, Ting Yang, Ting Yang, Min Guo, Min Guo, Qiu Li, Qiu Li, Jie Chen, Jie Chen, Tingyu Li, Tingyu Li   +13 more
doaj   +1 more source

Analysis of 3-hydroxyisovaleric acid and 3-hydroxybutyric acid in plasma samples by LC-MS/MS

, 2022
Down syndrome is a common genetic disorder that results from the presence of an extra chromosome in the 21st chromosome pair of humans. Metabolomics is an alternative method in discovery of new biomarkers for the screening and diagnosis of Down syndrome.
NEMUTLU, EMİRHAN, REÇBER, TUBA, ÖZKAN, ECE, KIR, SEDEF, BEKSAÇ, MEHMET SİNAN   +4 more
core   +1 more source