Results 11 to 20 of about 2,128 (126)

Two Cases of Hereditary Paraganglioma-Pheochromocytoma Syndrome in Siblings, Caused by a Novel Succinate Dehydrogenase Complex Subunit D Variant. [PDF]

IJU Case Rep
ABSTRACT Introduction Pheochromocytomas and paragangliomas are increasingly recognized as hereditary malignancies, with ~30%–40% of cases involving germline variants. We report a familial case of hereditary pheochromocytoma‐paraganglioma syndrome caused by a novel variant in the SDHD gene.
Nakamura R, Yamamoto Y, Kato T, Mukai K, Nomura M, Nojima S, Hatano K, Kakuta Y, Kawashima A, Nonomura N.   +9 more
europepmc   +2 more sources

Synthesis, Radiochemical Characterization, and Biodistribution of a ¹⁸⁸Re Analogue of [¹³¹I]mIBG in a Neuroblastoma Xenograft Model. [PDF]

J Labelled Comp Radiopharm
A 188Re analogue of [131I]mIBG was synthesized in moderate yields using 188Re‐4 + 1 chemistry. In vitro studies using SK‐N‐SH neuroblastoma cell lines demonstrated that the compound exhibited affinity for norepinephrine transporters expressed on these cancer cells.
Sakhare N, Kumar D, Das S, Mitra A, Mirapurkar S, Rani G, Sheela M, Chirayil V, Mohanty B, Mathur A, Mallia MB, Chaudhari P.   +11 more
europepmc   +2 more sources

Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements [PDF]

, 2020
The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac sympathetic nerve system in patients with heart failure and Parkinson's disease.
Buck, Andreas, Chen, Xinyu, Higuchi, Takahiro, Kudo, Takashi, Lapa, Constantin   +4 more
core   +2 more sources

The human norepinephrine transporter in combination with C-11-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy [PDF]

, 2005
Although the herpes simplex virus thymidine kinase gene has been frequently applied as a reporter gene for monitoring gene transfection in animals, it has some intrinsic limitations for use in humans.
Beerens, Antoine, Buursma, A.R., de Vries, E.F J, Haisma, H.J., Hospers, G.A.P., Rots, Marianne, Vaalburg, W., van Waarde, Aaren   +7 more
core   +7 more sources

Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target. [PDF]

, 2010
BACKGROUND: The proinflammatory and anti-inflammatory role of the sympathetic nervous system in early and late inflammation is an unresolved paradox. A drastic loss of sympathetic nerve fibres in the synovial tissue of patients with rheumatoid arthritis
Capellino S., Cosentino M., Grifka J., Schmidt M., Straub R.H., Wolff C.   +5 more
core   +1 more source

Current Trends in Functional Imaging of Pheochromocytomas and Paragangliomas [PDF]

, 2006
Most pheochromocytomas/paragangliomas should be evaluated with anatomical imaging (computed tomography or magnetic resonance imaging) followed by functional imaging (nuclear medicine modalities).
Anderson C.J., Averbuch S.D., B. L SHULKIN, Duet M., Gabriel M., Hoegerle S., I. ILIAS, Ilias I., J. C SISSON, K. PACAK, Lamberts S.W., Mamede M., Mundschenk J., Proye C., Schulz C., Shulkin B., Shulkin B.L., Shulkin B.L., Shulkin B.L., Sisson J.C., Tischler A., Trampal C., Wieland D.M.   +22 more
core   +1 more source

A case of marked improvement in pareidolia in untreated schizophrenia following antipsychotic treatment. [PDF]

PCN Rep
Abstract Background Pareidolia, the tendency to perceive meaningful images within ambiguous visual patterns, is commonly observed in neurodegenerative disorders and schizophrenia. Owing to the limited number of studies, the characteristics of pareidolia accompanying schizophrenia remain unclear.
Kato T, Seki E, Kumasaka T, Tsujii T, Mochizuki D, Kida H, Nikkuni S, Mizuno M, Sakuma K.   +8 more
europepmc   +2 more sources

Systems Radiology and Personalized Medicine [PDF]

, 2022
Medicine has evolved into a high level of specialization using the very detailed imaging of organs. This has impressively solved a multitude of acute health-related problems linked to single-organ diseases. Many diseases and pathophysiological processes,

core   +1 more source

The Impact of Directionality in Predications on Text Mining [PDF]

, 2008
The number of publications in biomedicine is increasing enormously each year. To help researchers digest the information in these documents, text mining tools are being developed that present co-occurrence relations between concepts. Statistical measures
Fiszman, Marcelo, Leroy, Gondy, Rindflesch, Thomas C.   +2 more
core   +4 more sources

A novel approach in the treatment of neuroendocrine gastrointestinal tumors: Additive antiproliferative effects of interferon-γ and meta-iodobenzylguanidine

BMC Cancer, 2004
Background Therapeutic options to effectively inhibit growth and spread of neuroendocrine gastrointestinal tumors are still limited. As both meta-iodobenzylguanidine (MIBG) and interferon-γ (IFNγ) cause antineoplastic effects in neuroendocrine ...
Ahnert-Hilger Gudrun, Huether Alexander, Sutter Andreas P, Höpfner Michael, Scherübl Hans   +4 more
doaj   +1 more source