Is Development of High-Grade Gliomas Sulfur-Dependent?
Molecules, 2014 We characterized γ-cystathionase, rhodanese and 3-mercaptopyruvate sulfurtransferase activities in various regions of human brain (the cortex, thalamus, hypothalamus, hippocampus, cerebellum and subcortical nuclei) and human gliomas with II to IV grade ...
Maria Wróbel +5 more
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Enzymatic activity of the Arabidopsis sulfurtransferase resides in the C-terminal domain but is boosted by the N-terminal domain and the linker peptide in the full-length enzyme [PDF]
, 2005 Sulfurtransferases/rhodaneses are a group of enzymes widely distributed in plants, animals, and bacteria that catalyze the transfer of sulfur from a donor molecule to a thiophilic acceptor substrate.
Burow, M. +2 more
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Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]
, 2012 The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant +85 more
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Cellular and Molecular Gastroenterology and Hepatology, 2018 Hydrogen sulfide (H2S) is a major physiologic gastrotransmitter. Its role in the regulation of the lower esophageal sphincter (LES) function remains unknown. The present study addresses this question.
Xiaopeng Bai +11 more
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The rhodanese RhdA helps Azotobacter vinelandii in maintaining cellular redox balance [PDF]
, 2010 The tandem domain rhodanese-homology protein RhdA of Azotobacter vinelandii shows an active-site loop structure that confers structural peculiarity in the environment of its catalytic cysteine residue.
Anderson A.J. +5 more
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Generation and Characterization of a CRISPR/Cas9—Induced 3-mst Deficient Zebrafish
Biomolecules, 2020 3-mercaptopyruvate sulfurtransferase (3-MST) is an enzyme capable of synthesizing hydrogen sulfide (H2S) and polysulfides. In spite of its ubiquitous presence in mammalian cells, very few studies have investigated its contribution to homeostasis and ...
Antonia Katsouda +4 more
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Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease
Antioxidants, 2021 Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (H2S)-releasing drugs, few have demonstrated the influence of endogenous H2S production.
Kevin M. Casin, John W. Calvert
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Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism [PDF]
, 2019 Elaborate antioxidant pathways have evolved to minimize the threat of excessive reactive oxygen species (ROS) and to regulate ROS as signaling entities.
Gao, Yan, Olson, Kenneth R.
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Production of hydrogen sulfide from D-cysteine and its therapeutic potential
Frontiers in Endocrinology, 2013 Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney and brain from ischemic insult. H2S
Norihiro eShibuya, Hideo eKimura
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Journal of Advanced Research, 2021 Background: Over the last several decades, hydrogen sulfide (H2S) has been found to exert multiple physiological functions in mammal systems. The endogenous production of H2S is primarily mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE)
Hai-Jian Sun +4 more
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