Results 41 to 50 of about 3,733 (181)

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284. [PDF]

FEBS Lett
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Di Napoli G, Fissore A, Salladini E, Raccuia E, Oliaro-Bosso S, Ruggiero A, Berisio R, Medina M, Velazquez-Campoy A, Adinolfi S, Marengo M.   +10 more
europepmc   +2 more sources

Impairment of hydrogen sulfide synthesis in chondrocytes under high glucose environment: a link between type 2 diabetes and osteoarthritis [PDF]

, 2018
Poster ...
Blanco García, Francisco J, Burguera, Elena F., Meijide-Faílde, Rosa, Vaamonde-García, Carlos   +3 more
core   +1 more source

Hypertension and Aging Affect Liver Sulfur Metabolism in Rats

Cells, 2021
Hypertension and age are key risk factors for cardiovascular morbidity and mortality. Hydrogen sulfide (H2S), a gaseous transmitter, contributes significantly to regulating arterial blood pressure and aging processes.
Dominika Szlęzak, Patrycja Bronowicka-Adamska, Tomasz Hutsch, Marcin Ufnal, Maria Wróbel   +4 more
doaj   +1 more source

The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues [PDF]

, 2011
The enzymes of the transsulfuration pathway, cystathionine --synthase (CBS) and cystathionine --lyase (CSE), are important for the endogenous production of hydrogen sulfide (H2S), a gaseous signaling molecule. The relative contributions of CBS and CSE to
Kery V, Linden DR, Mudd SH, Omer Kabil, Peter Xie, Ruma Banerjee, Victor Vitvitsky   +6 more
core   +1 more source

Escherichia coli Uses Separate Enzymes to Produce H2S and Reactive Sulfane Sulfur From L-cysteine

Frontiers in Microbiology, 2019
Hydrogen sulfide (H2S) has been proposed to have various physiological functions, and it may function through reactive sulfane sulfur. Since the two sulfur forms often coexist, they are normally considered interchangeable.
Kai Li, Yufeng Xin, Guanhua Xuan, Rui Zhao, Huaiwei Liu, Yongzhen Xia, Luying Xun, Luying Xun   +7 more
doaj   +1 more source

A Proteomic Approach to Study the Effect of Thiotaurine on Human Neutrophil Activation [PDF]

, 2017
Thiotaurine, a thiosulfonate related to taurine and hypotaurine, is formed by a metabolic process from cystine and generated by a transulfuration reaction between hypotaurine and thiocysteine.
A Ferrante, AK Mustafa, B Sörbo, BD Paul, BD Paul, C De Marco, C De Marco, D Cavallini, D Cavallini, D Cavallini, DB Learn, E Capuozzo, E Capuozzo, E Cuevasanta, EG Mueller, F Di Domenico, GX Luo, H Beinert, H Kimura, J Dragotto, J Westley, JI Toohey, JI Toohey, L Cattaneo, M Whiteman, M Whiteman, MR Hara, O Kabil, PK Yadav, RCO Zanardo, S Canterini, S Singh, TR Chauncey, TV Mishanina   +33 more
core   +2 more sources

MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT

Redox Biology, 2022
Background & aims: Excessive inflammatory responses and oxidative stress are considered the main characteristics of inflammatory bowel disease (IBD). Endogenous hydrogen sulfide (H2S) has been reported to show anti-inflammatory activity in IBD.
Jie Zhang, Li Cen, Xiaofen Zhang, Chenxi Tang, Yishu Chen, Yuwei Zhang, Mengli Yu, Chao Lu, Meng Li, Sha Li, Bingru Lin, Tiantian Zhang, Xin Song, Chaohui Yu, Hao Wu, Zhe Shen   +15 more
doaj   +1 more source

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39) [PDF]

, 2014
Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction.
Cai, Caliendo, Campolo, Chan, Chen, Cortese-Krott, Davidson, Fox, Fu, Halliwell, Kondo, Lavu, Li, Li, Li, Li, Liu, Liu, Liu, Mani, Merighi, Mkrtchyan, Murphy, Módis, Módis, Ohtsuki, Park, Paul, Perry, Robinson, Robinson, Shibuya, Shirozu, Smith, Suzuki, Szabo, Teng, Thorson, Thurnhofer, Vacek, Vandiver, Wallace, Wang, Wang, Watanabe, Weksler, Whiteman, Whiteman, Whiteman, Whiteman, Whiteman, Whiteman, Xu, Yang, Yin   +54 more
core   +1 more source

The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma

Frontiers in Pharmacology, 2023
With an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in the world. It is also the primary reason for cancer-related death in the world. The pathogenesis of HCC is complex, such as
Huijie Zhao, Yanting Zhang, Yanting Zhang, Xiaodi Fu, Chaoren Chen, Saadullah Khattak, Saadullah Khattak, Honggang Wang   +7 more
doaj   +1 more source

In Vivo Anti-inflammatory Activity of Lipoic Acid Derivatives in Mice  [PDF]

, 2013
Background: In mammals lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA) function as cofactors for multienzymatic complexes catalyzing the decarboxylation of α-ketoacids.
Anna Bilska-Wilkosz, Brunon Kwiecień, Inga Kwiecień, Jacek Sapa, Joanna Knutelska, Lidia Włodek, Magdalena Dudek, Marek Bednarski, Maria Sokołowska-Jeżewicz, Małgorzata Iciek, Małgorzata Zygmunt   +10 more
core   +1 more source