Results 61 to 70 of about 3,761 (182)

SseA, a 3-mercaptopyruvate sulfurtransferase fromEscherichia coli: crystallization and preliminary crystallographic data [PDF]

Acta Crystallographica Section D Biological Crystallography, 2002
SseA, the translation product of the Escherichia coli sseA gene, is a 31 kDa protein endowed with 3-mercaptopyruvate:cyanide sulfurtransferase activity in vitro. As such, SseA is the prototype of a sulfurtransferase subfamily distinguished from the better known rhodanese sulfurtransferases, which display thiosulfate:cyanide sulfurtransferase activity ...
A. Spallarossa, A. Carpen, F. Forlani, S. Pagani, M. Bolognesi, D. Bordo   +5 more
openaire   +3 more sources

A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery [PDF]

, 2017
Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated.
Alexander, Stephen P.H., Donovan, J., Dunn, William R., Garle, M.J., Ralevic, Vera, Roberts, Richard E., Wong, P.S.   +6 more
core   +2 more sources

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]

, 2016
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya, Hellmich, Mark R., Marcatti, Michela, Nagy, Péter, Szabo, Csaba, Szczesny, Bartosz, Wiktorowicz, John E., Zatarain, John R.   +7 more
core   +1 more source

Scientific opinion on the acute health risks related to the presence of cyanogenic glycosides in raw apricot kernels and products derived from raw apricot kernels [PDF]

, 2016
Peer reviewedPublisher ...

core   +3 more sources

Hydrogen Sulfide and Polysulfides as Biological Mediators

Molecules, 2014
Hydrogen sulfide (H2S) is recognized as a biological mediator with various roles such as neuromodulation, regulation of the vascular tone, cytoprotection, anti-inflammation, oxygen sensing, angiogenesis, and generation of mitochondrial energy.
Hideo Kimura
doaj   +1 more source

Mitochondrial Sulfide Detoxification Requires a Functional Isoform O-Acetylserine(thiol)lyase C in Arabidopsis thaliana [PDF]

, 2012
In non-cyanogenic species, the main source of cyanide derives from ethylene and camalexin biosyntheses. In mitochondria, cyanide is a potent inhibitor of the cytochrome c oxidase and is metabolised by the β-Cyanoalanine synthase CYS-C1, catalysing the ...
García Fernández, Irene, Gotor Martínez, Cecilia, Romero González, Luis Carlos, Álvarez Núñez, Consolación   +3 more
core   +1 more source

Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival [PDF]

Cell Chemical Biology, 2020
H2S-producing enzymes in bacteria have been shown to be closely engaged in the process of microbial survival and antibiotic resistance. However, no inhibitors have been discovered for these enzymes, e.g., 3-mercaptopyruvate sulfurtransferase (MST). In the present study, we identified several classes of inhibitors for Escherichia coli MST (eMST) through
Giorgia Croppi, Yueyang Zhou, Rong Yang, Yunfei Bian, Mingtao Zhao, Youtian Hu, Benfang Helen Ruan, Jing Yu, Fang Wu   +8 more
openaire   +2 more sources

Regulation of the T-type Ca²⁺ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H₂S in nociception [PDF]

, 2015
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide.
Abe, Andersson, Avanzato, Benavides, Berridge, Bezprozvanny, Bourinet, Bourinet, Boycott, Carbone, Catterall, Chemin, Chevalier, Choe, Chris Peers, Clapham, Coste, Cribbs, Dolphin, Dziegielewska, Elies, Emerick, Feng, Francois, Francois, Francois, Gadotti, Garcia-Caballero, Gonzalez, Hsu, Huang, Huguenard, Iftinca, Jackson-Weaver, Jacobo Elies, Jacus, Jagodic, Jagodic, Jason L. Scragg, Jevtovic-Todorovic, John P. Boyle, Joksovic, Kang, Kang, Kawabata, Kim, Kimura, Kuksis, Kuo, Kuo, Latham, Latour, Lee, Lee, Leffler, Li, Li, Lipscombe, Maeda, Marger, Matsunami, Messinger, Moore, Moran, Mustafa, Nagai, Nelson, Nelson, Nelson, Nelson, Nikita Gamper, Nowycky, Orestes, Orestes, Paul, Paul, Peers, Peers, Perez-Reyes, Rajan, Rose, Sekiguchi, Shibuya, Shin, Shipston, Sitdikova, Stadtman, Sun, Szabo, Takahashi, Telezhkin, Todorovic, Todorovic, Todorovic, Todorovic, Tzeng, Wang, Waxman, Weiss, White, Wilkinson, Zamponi, Zhang   +102 more
core   +2 more sources

Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity

Nitric Oxide, 2018
Hydrogen sulfide (H2S) is produced by the action of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) or 3-mercaptopyruvate sulfurtransferase (3-MST). 3-MST converts 3-mercaptopyruvate (MPT) to H2S and pyruvate. H2S is recognized as an endogenous gaseous mediator with multiple regulatory roles in mammalian cells and organisms.
Mitidieri E, Tramontano T, GURGONE, DANILA, Citi V, Calderone V, Brancaleone V, KATSOUDA, DIMITRA, Nagahara N, Papapetropoulos A, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R, SORRENTINO, RAFFAELLA   +12 more
openaire   +6 more sources

Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism

Antioxidants, 2023
Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals.
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike   +13 more
doaj   +1 more source