Results 111 to 120 of about 5,846 (172)

Sulindac sulfide suppresses oncogenic transformation through let-7b-mediated repression of K-Ras signaling. [PDF]

Cell Death Discov
Liang Z, Ma R, Yi B, Riker AI, Xi Y.
europepmc   +1 more source

Risk assessment of four polycyclic aromatic hydrocarbons in South Korean sesame oil products. [PDF]

Food Sci Biotechnol
Hong DE, Jeong DH, Kim S, Lee HS.
europepmc   +1 more source

Generation and characterization of a Cre-inducible ZNF768 overexpression mouse model. [PDF]

Sci Rep
Poirier A, Tribouillard L, Kordahi M, Gélinas Y, Roy J, Beaulieu MJ, Orain M, Blanchet MR, Joubert P, Laplante M.   +9 more
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Proteomic Characterization Reveals CYP2S1 as a Mediator of Drug Resistance in PDAC. [PDF]

Pancreas
Thiel V, Nadler WM, Kerner A, Kuhlmann L, Reitberger M, Vorberg T, Schwerd-Kleine P, Noll E, Giese NA, Yen HY, Steiger K, Vogel V, Klein C, Hackert T, Koschny R, Opitz CA, Trumpp A, Sprick MR, Rösli C.   +18 more
europepmc   +1 more source

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Fungal oxidation of 3-methylcholanthrene: Formation of proximate carcinogenic metabolites of 3-methylcholanthrene

Chemico-Biological Interactions, 1982
The filamentous fungus, Cunninghamella elegans, was found to metabolize the potent carcinogen, 3-methylcholanthrene (3-MC) to 1-hydroxy-3-MC, 2-hydroxy-3-MC, 1-keto-3-MC, 2-keto-3-MC and trans-9,10-dihydrodiols of 1-hydroxy-3-MC. In addition several unidentified derivatives of 3-MC were found.
D T Gibson, C E Cerniglia
exaly   +3 more sources

The identification of 3-methylcholanthrene-9,10-dihydrodiol as an intermediate in the binding of 3-methylcholanthrene to DNA in cells in culture

Chemico-Biological Interactions, 1978
Two metabolites of 3-methylcholanthrene (3MC), previously shown to be precursors of the DNA-bound form of 3MC observed in embryo cells in culture, were prepared from 3MC by microsomal metabolism and isolated by high pressure liquid chromatography (HPLC).
P Brookes, M R Osborne, M R Osborne
exaly   +3 more sources

Metabolism of 3-methylcholanthrene in rat liver cytosol

Chemico-Biological Interactions, 1989
The present study investigates the metabolism of the potent carcinogen 3-methylcholanthrene in rat liver cytosol preparations. Three metabolites of 3-methylcholanthrene were characterized by HPLC and GC/MS analysis. These metabolites were identified as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene and cholanthrene.
James W Flesher, Steven R Myers, S R Myers   +2 more
exaly   +3 more sources

Synthesis of 3-methylcholanthrene

Tetrahedron Letters, 1981
Abstract A novel synthesis of 3-methylcholanthrene is described which is operationally sipmler than the method in current use and is potentially applicable to the synthesis ofa wide range of other polycyclic hydrocarbons and their cracinogenic metabolites.
Stephen A. Jacobs, Ronald G. Harvey
openaire   +1 more source

Microsomal and nuclear metabolism of 3-methylcholanthrene

Biochemical Pharmacology, 1979
Abstract Hepatic nuclei and microsomes prepared from rats pretreated with 3-methyleholanthrene, or hepatic nuclei prepared from untreated rats, were incubated with generally 3H-labeled 3-methylcholanthrene in the presence of an NADPH-generating system.
B, Tierney, E, Bresnick, P, Sims, P L, Grover   +3 more
openaire   +2 more sources

Metabolism of 3-methylcholanthrene in rat pancreas

Digestive Diseases and Sciences, 1981
In vitro and in vivo studies revealed that pancreases of Long-Evans male rats metabolized 3-methylcholanthrene (3MC) principally at the 1- and 2-carbon positions. The pancreatic metabolizing capability was not induced by pretreatment with either benzo(a)pyrene (BP) or phenobarbital (PB).
O, Black, E, Murrill, C, Fanska
openaire   +2 more sources