Results 121 to 130 of about 5,846 (172)
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Archives of Pharmacal Research, 1993
This study has been undertaken to examine the effect of 3-methylcholanthrene (3MC) on rat uterine growth and to understand the mechanism of action of 3MC in rat uterus. After diethylstilbesterol(DES) or tamoxifen(TAM) or 3MC or DES plus TAM or DES plus 3MC was administered into immature female rats, uterine weight of each group was measured.
Yhun Y. Sheen, Sun S. Kim, Hea C. Yun
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This study has been undertaken to examine the effect of 3-methylcholanthrene (3MC) on rat uterine growth and to understand the mechanism of action of 3MC in rat uterus. After diethylstilbesterol(DES) or tamoxifen(TAM) or 3MC or DES plus TAM or DES plus 3MC was administered into immature female rats, uterine weight of each group was measured.
Yhun Y. Sheen, Sun S. Kim, Hea C. Yun
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Carcinogenesis, 1986
DNA prelabelled in the purine or pyrimidine bases was reacted with anti-7,8-epoxy-trans-9,10-dihydroxy-7,8,9,10-tetra-hydro-3-methylchol ant hrene (anti-3MCDE). Enzymic degradation and column chromatography allowed the isolation of a number of hydrocarbon--nucleoside derivatives.
M R, Osborne +3 more
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DNA prelabelled in the purine or pyrimidine bases was reacted with anti-7,8-epoxy-trans-9,10-dihydroxy-7,8,9,10-tetra-hydro-3-methylchol ant hrene (anti-3MCDE). Enzymic degradation and column chromatography allowed the isolation of a number of hydrocarbon--nucleoside derivatives.
M R, Osborne +3 more
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Karyology of Rhabdomyosarcomas Induced with 3-Methylcholanthrene
Tumori Journal, 1972This work aims to find out how a neoplastic condition affects the chromosome set of the rat. Malignant tumors were induced by 3-methylcholanthrene in adult rats. The karyologic examination of 3 sarcomas (S1, S2, S3) showed that: in S1 65% of the metaphases are hypotetraploid; in S2 75% of the metaphases are roughly diploid and only 25 % are ...
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Progestin secretion in 3‐methylcholanthrene‐treated rats
International Journal of Cancer, 1972AbstractThe mechanism of deciduomata maintenance by 3‐methylcholanthrene (MCA) was investigated in normally cycling Sprague‐Dawley rats. Animals received daily injections of ovine prolactin (LTH) from days 1‐4 following estrus (pre‐trauma period).
R C, Moon, S, Young
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Serum increases CYP1A1 induction by 3-methylcholanthrene
Biochemical and Biophysical Research Communications, 2002CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. We have previously demonstrated that fetal bovine serum (FBS) induces CYP1A1 gene transcription.
Quoc-Binh, N'Guyen +9 more
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Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene
Life Sciences, 1977Abstract Groups of adult male rats treated with 3-methylcholanthrene, phenobarbital or vehicles alone, were administered caffeine either orally or intravenously. Serum caffeine concentrations were measured by radioimmunoassay. In vehicle and phenobarbital pretreated animals, caffeine elimination kinetics were non-linear. In control animals, the in
A, Aldridge, W D, Parsons, A H, Neims
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Biochemistry and molecular biology international, 1996
Hydroxylation of a meso-anthracenic carbon atom with subsequent formation of a reactive ester bearing a good leaving group (e.g., sulfate) has been proposed as a possible biochemical mechanism responsible for DNA binding, mutagenicity and tumorigenicity of 3-methylcholanthrene, one of the most potent carcinogenic polycyclic aromatic hydrocarbons in ...
H K, Jeong, M, Shlyankevich, Y J, Surh
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Hydroxylation of a meso-anthracenic carbon atom with subsequent formation of a reactive ester bearing a good leaving group (e.g., sulfate) has been proposed as a possible biochemical mechanism responsible for DNA binding, mutagenicity and tumorigenicity of 3-methylcholanthrene, one of the most potent carcinogenic polycyclic aromatic hydrocarbons in ...
H K, Jeong, M, Shlyankevich, Y J, Surh
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ChemInform Abstract: SYNTHESIS OF 3‐METHYLCHOLANTHRENE
Chemischer Informationsdienst, 1981AbstractAus dem 4‐Methyl‐1‐indanon (I) erhält man mit der Li‐Verbindung (II) das Phthalid (III),das mit Zn zu (IV) reduziert und zum Derivat (V) cyclokondensiert wird.
S. A. JACOBS, R. G. HARVEY
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Pharmacology & Toxicology, 1991
Abstract:Foetal mice of genotype AhbAhd(responsive to induction of metabolism of polycyclic aromatic hydrocarbons [PAH]) or AhdAhd(non‐responsive) were exposed transplacentally on gestation day 17 to a single dose of 3‐methylcholanth‐rene (MC, 5–17. mg/kg) with or without prior treatment on day 15 with β‐naphthoflavone (βNF, 150 mg/kg).
L M, Anderson, A B, Jones, C W, Riggs
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Abstract:Foetal mice of genotype AhbAhd(responsive to induction of metabolism of polycyclic aromatic hydrocarbons [PAH]) or AhdAhd(non‐responsive) were exposed transplacentally on gestation day 17 to a single dose of 3‐methylcholanth‐rene (MC, 5–17. mg/kg) with or without prior treatment on day 15 with β‐naphthoflavone (βNF, 150 mg/kg).
L M, Anderson, A B, Jones, C W, Riggs
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Anti-uterotrophic Response of Immature Mice to 3-Methylcholanthrene
Nature, 1969As well as its ability to induce cancer in various tissues, the polycyclic hydrocarbon 3-methylcholanthrene (MCA) is capable of affecting the activity of certain endocrine glands1–3 and altering the metabolism of several hormones4–7. Indirect evidence from several sources6,8–12 indicates that, in various experimental conditions, MCA may be capable of ...
W C, Newman, R C, Moon
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