Results 131 to 140 of about 5,846 (172)

Interaction of 3-Methylcholanthrene with Lecithin—Cholesterol Mixed Films

Journal of Pharmaceutical Sciences, 1971
The interaction of a carcinogenic hydrocarbon, 3-methylcholanthrene, with mixed films of various mole fractions of cholesterol and lecithin was investigated. The extent of interaction between 3-methylcholanthrene and cholesterol in the mixed films is greatly influenced by the competitive interaction between cholesterol and the phospholipid.
N D, Weiner, I, Chawdry, A, Felmeister
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The influence of vitamin a on the susceptibility of the rat lung to 3‐methylcholanthrene

International Journal of Cancer, 1976
AbstractThe susceptibility of rats to pulmonary carcinogens is increased in the absence of vitamin A intake even when considerable amounts (0.4 nmole/mg) of vitamin A are stored in the liver and deficiency symptoms are absent. This was demonstrated in studies on the induction of metaplastic lung nodules by intratracheally administered 3 ...
P, Nettesheim, M L, Williams
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Effects of 3-methylcholanthrene administration on the proteins of endoplasmic reticulum

Biochemical Pharmacology, 1971
Abstract The effects of the polycyclic hydrocarbon, 3-methylcholanthrene, have been studied on the proteins of the smooth and rough endoplasmic reticulum. The evidence indicated that 3-methylcholanthrene caused a more rapid increase in the incorporation of 14 C-labeled amino acid mixture into these components and a slower degradation of the proteins.
O, Black, E T, Cantrell, R J, Buccino, E, Bresnick   +3 more
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Effects of 3‐methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen

Journal of Applied Toxicology, 1992
AbstractThis report presents a set of investigations on the hepatotoxic action of acetaminophen (AA). Male mice of Balb C strain were given [3H]acetaminophen in doses of 100, 300 and 600 mg kg−1 with or without pretreatment with 3‐methylcholanthrene (3MCh) or diethyl maleate (DEM).The results of this study show that AA administered in moderate doses ...
J A, Szymańska, E A, Swietlicka, J K, Piotrowski, M, Skrzypińska-Gawrysiak, S, Sporny   +4 more
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Ultrastructural and biochemical effects of 3-methylcholanthrene in rainbow trout

Bulletin of Environmental Contamination and Toxicology, 1995
Effluent discharged from industrial operations often contains a variety of chemicals which can be cytotoxic, mutagenic and carcinogenic in nature. Among these xenobiotic chemicals, the polyaromatic hydrocarbons (PAH) are frequently present in contaminated aquatic environments. Fish absorb these PAH and metabolize them, primarily in liver, by cytochrome
A A, Khan, S S, Semalulu
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The formation of dihydrodiols by chemical or enzymic oxidation of 3-methylcholanthrene

Chemico-Biological Interactions, 1978
The chemical oxidation of 3-methylcholanthrene in an ascorbic acid-ferrous sulphate-EDTA reaction mixture gave all five possible dihydrodiols. The structures and stereochemistry of the dihydrodiols were shown by UV, mass and NMR spectral studies and by chemical examination to be cis-2a,3-dihydroxy-3-methylcholanthrene, trans-4,5-dihydro-4,5-dihydroxy-3-
B, Tierney, A, Hewer, H, Rattle, P L, Grover, P, Sims   +4 more
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The carcinogenic activities in mice of compounds related to 3‐methylcholanthrene

International Journal of Cancer, 1967
AbstractA number of derivatives of 3‐methylcholanthrene have been tested for carcinogenic action by injection into C57 black mice. 1‐ and 2‐Hydroxy‐3‐methylcholanthrene and 3‐methylcholanthrene‐1‐ and 2‐one were active carcinogens, but cis‐1,2‐dihydroxy‐3‐methylcholanthrene showed only weak activity. The hydrocarbon, 3‐methylcholanthrylene (1,2‐dehydro‐
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Intradermal 3-Methylcholanthrene in Rabbits and Mice

Dermatologica, 2009
R, Fleischmajer, J V, Lara, P, Charoenvej   +2 more
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Mutagenesis of human cells by 3-methylcholanthrene

Mutation Research, 1979
R D, Curren, C J, Homer, P J, Price, A E, Freeman   +3 more
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3-Methylcholanthrene-Induced Thyroiditis in Buffalo Strain Rats

Archives of Environmental Health: An International Journal, 1970
Inbred adult Buffalo strain male and female rats were given 0.033% 3-methylcholanthrene continuously in the diet. They were killed after 4, 8, 12, 16, 24, and 52 weeks. The incidence of rats with thyroiditis tended to increase with continued ingestion of the chemical.
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