Results 51 to 60 of about 5,846 (172)

A highly efficient synthesis of 3-methylcholanthrene

The Journal of Organic Chemistry, 1993
A five-step synthesis of 3-methylcholanthrene (1) has been achieved starting from 5-methylhomophthalic anhydride and N,N-diethyl-1-naphthamide in 55% overall yield. Treatment of a solution of the preformed lithium enolate of 5-methylhomophthalic anhydride (3) with an equimolar solution of 2-lithio-1-naphthamide (4), followed by acid hydrolysis ...
Thanasis Gimisis, Masato Koreeda
openaire   +2 more sources

Dormant Metastases Exhibit a Unique Phenotype Primarily Promoted by the Ch25h Gene and Are Maintained in Dormancy by T Lymphocytes

MedComm, Volume 6, Issue 11, November 2025.
Significance: Immune‐controlled dormant metastases exhibit a unique phenotype, primarily promoted by the Ch25h gene, that can be exploited to discover new biomarkers, as well as the development of therapies to eradicate dormant metastases or control overt metastases.
Virginia Chamorro, Ignacio Algarra, Verónica Sanz, María Pulido, Irene Romero, Estefanía Chico, Marina Millán, María Escaño‐Maestre, Pablo Botella, Isabel Linares, Ángel M. García‐Lora   +10 more
wiley   +1 more source

Histofluorescence of 3-methylcholanthrene metabolites in the rat pancreas

Gastroenterology, 1978
Pancreases of Long-Evans rats were treated in vitro and in vivo with 3-methylcholanthrene and examined by histofluorescence techniques. For in vitro studies, tissue sections were dipped in 3-methylcholanthrene and incubated in vitro. These sections revealed that acinar and ductal epithelium had equal fluorescence which suggested equal metabolic ...
openaire   +2 more sources

Biological J‐Coupling Spectroscopy at Low Magnetic Field

Small Science, Volume 5, Issue 11, November 2025.
The strong J(C,H)‐coupling from [2‐13C] pyruvate is exploited to measure the pyruvate‐to‐lactate conversion in cancer cells at low magnetic fields. This is combined with a parahydrogen‐induced polarizationprotocol optimized to provide a biocompatible solution with 20 000‐fold signal enhancement.
Gonzalo G. Rodriguez, Charlotte von Petersdorff‐Campen, Sergey Korchak, Oscar Sucre, Maria D. Santi, Josef Elsasser, Ruhuai Mei, Lisa M. Fries, Jan Felger, Andrea Markus, Frauke Alves, Stefan Glöggler   +11 more
wiley   +1 more source

Targeted Therapies in the Most Common Advanced Solid Tumors, Drug Resistance, and Counteracting Progressive Micrometastatic Disease: The Next Frontier of Research

MedComm, Volume 6, Issue 10, October 2025.
In TME, undetectable DCCs (panel A) join with a low tumor burden along with low immune suppression, that favor successful immune manipulation through immune suppression inhibiting immune‐therapy. This moves the immune balance toward the immune response and likely makes more stable the dormant state of DCCs in the unstable metastatic niche and/or allows
Andrea Nicolini, Paola Ferrari, Roberto Silvestri, Dario A. Bini   +3 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, Volume 2, Issue 3, September 2025.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. This study was performed to find which types of hepatic CYP isoforms are responsible for the metabolism of mirodenafil (a new erectogenic) and one of its metabolite, SK3541, using various hepatic CYP inducers and inhibitors in rats.
Young Hee Choi, Young Sun Lee, Myung Gull Lee, Tae Kon Kim, Bong-Yong Lee   +4 more
doaj   +1 more source

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

Advanced Science, Volume 12, Issue 31, August 21, 2025.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo, Yuting Luo, Sicheng Chen, Tiantian Yang, Bixia Liu, Xiting Liao, Xiaoke Zheng, Tian Tian, Jinxu Liu, Qinru Zhan, Xiaohua Situ, Zhongpeng Xie, Yanxia Wang, Zhe‐Sheng Chen, Honglei Chen, Zheng Yang, Zunfu Ke   +16 more
wiley   +1 more source

Animal models of lung cancer: Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms

Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1229-1252, July 2025.
Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang, Xianbin Zhao, Lili Tan, Pingxinyi Que, Tong Zhao, Wei Huang, Dejiao Yao, Songqi Tang   +7 more
wiley   +1 more source

Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass.

PLoS ONE, 2015
Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj   +1 more source