Results 11 to 20 of about 13,314,497 (296)

Design, Synthesis and Anti-Lung Cancer Evaluation of 1, 2, 3-Triazole Tethered Dihydroartemisinin-Isatin Hybrids. [PDF]

Front Pharmacol, 2021
A series of 1,2,3-triazole tethered dihydroartemisinin-isatin hybrids 8a-c and 9a-k were designed and synthesized. Their antiproliferative activity against A549, doxorubicin-resistant A549 (A549/DOX) as well as cisplatin-resistant A549 (A549/DDP) lung cancer cell lines was also investigated in this study.
Hou H, Qu B, Su C, Hou G, Gao F.
europepmc   +5 more sources

Identification of 8-Azaguanine Biosynthesis–Related Genes Provides Insight Into the Enzymatic and Non-enzymatic Biosynthetic Pathway for 1,2,3-Triazole

Frontiers in Bioengineering and Biotechnology, 2020
8-Azaguanine (1) is a special 1,2,3-triazole containing natural product that possesses potent antibacterial and antitumor activities. In the present study, the entire 8-azaguanine biosynthetic gene cluster was located from Streptomyces CGMCC4.1633 ...
Feifei Hou, Feifei Hou, Yupeng Wan, Yupeng Wan, Qi Gan, Mo Xian, Wei Huang   +6 more
doaj   +1 more source

Three-component synthesis of 1,2,3-triazoles in the presence of PVC-supported triazole-copper complex by click reaction [PDF]

شیمی کاربردی روز, 2020
In this research work novel PVC-supported triazole-copper(I) iodide catalyst (PVC–Triazole–CuI) was prepared and used the for synthesis of 1,2,3-triazoles.
Ali Keivanloo, Mostafa Gholizadeh, Elnaz Rezaii   +2 more
doaj   +1 more source

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The resistance of such strains as Staphylococcus aureus, Escherichia coli extends to many antimicrobial drugs. This problem can be solved by searching for new drugs with high bactericidal and antifungal action.
Ye. O. Karpun, N. M. Polishchuk
doaj   +1 more source

Synthesis and Characterization of the Triazole Derived from Thiosemicarbazide, 4-Amino-5-Phenyl-4H-1,2,4- Triazole-3-Thiol and Their Copper(II) and Nickel(II) Complexes [PDF]

Engineering and Technology Journal, 2013
Triazole N-(3-mercapto-5-phenyl-4H-1,2,4-triazol-4-yl)hydrazinecarbothioamide prepared in good yield via the condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and thiosemicarbazide.
Hamdan Abood Aday
doaj   +1 more source

Triazoles as promising small molecules anticancer agents [PDF]

Records of Pharmaceutical & Biomedical Sciences
The 1,2,3-triazole scaffold has emerged as a pivotal heterocyclic motif in medicinal chemistry due to its unique physicochemical properties, synthetic accessibility, and broad spectrum of biological activities. These five-membered nitrogen-rich rings are
Mennatallah Shaheen, Khaled Darwish, Safaa Kishk, Magda Elsayed, Ismail Salama   +4 more
doaj   +1 more source

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

Alkylation and Acylation of the 1, 2, 3-Triazole Ring

Chemical and Pharmaceutical Bulletin, 1997
Trimethylsilylaion of 1, 2, 3-triazole regioselectively proceeded to give 2-trimethylsilyl-2H-1, 2, 3-triazole, which was treated with primary alkyl halides in the presence of tetrabutylammonium fluoride to give 1-alkyl-1H-1, 2, 3-triazoles as a sole product.
OHTA, Shunsaku, KAWASAKI, Ikuo, UEMURA, Takahiro, YAMASHITA, Masayuki, YOSHIOKA, Tomomichi, YAMAGUCHI, Satoshi   +5 more
openaire   +2 more sources

Three-component reaction between ethyl carbazate, potassium selenocyanate and aroyl chlorides: Synthesis of 1,2,4-triazole-3-selones

, 2022
We reported a three-component, simple, one-pot, and novel method for the synthesis of 1,2,4-triazole-3-selones from the condensation of potassium selenocyanate and aroyl chlorides with ethyl carbazate at room temperature.
Mohsen Mohammadi (5593175), Razieh Mohebat (3348872), Mohammad H. Mosslemin (7479770), Alireza Hassanabadi (586732)   +3 more
core   +1 more source

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. We have continued the study of 1,2,4-triazole derivatives, which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus.
Yu. G. Samelyuk , A. G. Kaplaushenko
doaj   +1 more source