Results 111 to 120 of about 9,649,671 (339)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Book Review: Haberkorn, Tyrell, Revolution Interrupted: ...

open access: yesJournal of Current Southeast Asian Affairs, 2012
Book Review of the monograph: Haberkorn, Tyrell (2011), Revolution Interrupted: Farmers, Students, Law and Violence in Northern Thailand Madison, Wisconsin: University of Wisconsin Press, ISBN: 978 0 299 28184 7, 256 ...
Fabian Drahmoune
doaj  

A 300 GHz "Always-in-Focus" Focusing System for Target Detection [PDF]

open access: yes, 2013
A focusing system for a 300 GHz radar with 5 m target distance and 10 mm diameter spot size resolution is proposed. The focusing system is based on a Gaussian telescope scheme and its main parameters have been de¬signed using Gaussian beam quasi-optical ...
Garcia-Muñoz, L. E.   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Knowing Left From Right: Ideological Identification in Brazil, 2002-2006 Diferenciando a Esquerda da Direita: Identificação Ideológica no Brasil, 2002-2006

open access: yesJournal of Politics in Latin America, 2010
Ideology, typically defined on a left-right spectrum, should provide a means of communication between elites and masses. After years of leftist party rule, have Brazilian voters internalized ideological divisions? Longitudinal surveys conducted from 2002
Barry Ames, Amy Erica Smith
doaj  

INTEGRAL high energy detection of the transient IGR J11321-5311

open access: yes, 2007
Context: The transient hard X-ray source IGR J11321-5311 was discovered by INTEGRAL on June 2005, during observations of the Crux spiral arm. To date, this is the only detection of the source to be reported by any X/gamma-ray mission.
A. B. Hill   +17 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Governance Obstacles to Geothermal Energy Development in Indonesia

open access: yesJournal of Current Southeast Asian Affairs, 2015
Despite having 40 per cent of the world’s potential for geothermal power production, Indonesia exploits less than five per cent of its own geothermal resources.
Matthew S. Winters, Matthew Cawvey
doaj  

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