Results 81 to 90 of about 9,649,671 (339)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Internationalisation of Mainland Chinese Firms into Malaysia: From Obligated Embeddedness to Active Embeddedness

Journal of Current Southeast Asian Affairs, 2014
This paper examines the rationale by which mainland Chinese firms choose their coalition partners in their Malaysian ventures. I explore how, under certain political economic conditions, such cross-border investment and corporate tie-ups can be shaped to
Guanie LIM
doaj  

Interferometry of Direct Photons in Central 280Pb+208Pb Collisions at 158A GeV

, 2003
Two-particle correlations of direct photons were measured in central 208Pb+208Pb collisions at 158 AGeV.
A. K. Dubey, A. Kugler, A. L. S. Angelis, A. Lebedev, A. Maximov, A. Nianine, A. Oskarsson, A. Tsvetkov, A. Vinogradov, A. Vodopianov, B. Batiounia, B. C. Sinha, B. Guskov, B. K. Nandi, B. Mohanty, B. W. Kolb, B. Wysłouch, C. Blume, C. Roy, D. Bucher, D. Morrison, D. P. Mahapatra, D. Peressounko, D. S. Mukhopadhyay, D. Silvermyr, E. C. v.d. Pijll, E. Stenlund, F. J. M. Geurts, F. Plasil, F. Retiere, G. C. Mishra, G. J. v. Nieuwenhuizen, G. Martínez, G. R. Young, G. Roland, G. Shabratova, G. Sood, G. Stefanek, H. Büsching, H. Delagrange, H. H. Gutbrod, H. Kalechofsky, H. Löhner, H. Naef, H. Schlagheck, H. Å. Gustafsson, H.-R. Schmidt, I. Hrivnacova, I. Kosarev, I. Koutcheryaev, I. Otterlund, I. Roufanov, I. Sibiriak, J. M. Rubio, J. Nystrand, J. Rak, K. B. Bhalla, K. El Chenawi, K. Enosawa, K. Kadija, K. Karadjev, K. Karpio, K. Reygers, K. Söderström, L. Carlén, L. Luquin, L. Rosselet, L. Tykarski, M. Ippolitov, M. Kurata, M. L. Purschke, M. M. Aggarwal, M. Martin, M. P. Decowski, M. R. Dutta Majumdar, M. S. Ganti, M. Sumbera, M.-J. Mora, N. K. Rao, N. Slavine, N. v. Eijndhoven, O. Gavrishchuk, P. Donni, P. Kulinich, P. Nilsson, P. Nomokonov, P. Stankus, P. Steinberg, P. V. K. S. Baba, R. Glasow, R. Raniwala, R. Santo, S. Bathe, S. C. Phatak, S. Chattopadhyay, S. Fokin, S. Garpman, S. K. Badyal, S. K. Nayak, S. Nikolaev, S. Nishimura, S. P. Sørensen, S. Raniwala, S. S. Sambyal, S. Sato, S. Vörös, T. Bernier, T. C. Awes, T. H. Shah, T. K. Ghosh, T. K. Nayak, T. Moukhanova, T. Peitzmann, T. Siemiarczuk, T. Svensson, V. Antonenko, V. Arefiev, V. Astakhov, V. Avdeitchikov, V. Frolov, V. Manko, V. Nikitine, V. Petracek, V. S. Bhatia, W. Bauer, W. Pinganaud, Y. Miake, Y. P. Viyogi, Y. Schutz, Z. Ahammed   +129 more
core   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

New Developments in India–Myanmar Bilateral Relations?

Journal of Current Southeast Asian Affairs, 2015
The article deals with bilateral relations between India and Myanmar. It argues that the current transformation processes offer a unique opportunity for a major readjustment of India’s foreign policy towards Myanmar. In taking on India’s perspective,
Pierre Gottschlich
doaj  

Planar CuO_2 hole density estimation in multilayered high-T_c cuprates

, 2011
We report that planar CuO_2 hole densities in high-T_c cuprates are consistently determined by the Cu-NMR Knight shift. In single- and bi-layered cuprates, it is demonstrated that the spin part of the Knight shift K_s(300 K) at room temperature ...
A. Abragam, Akira Iyo, H. Yasuoka, Hidekazu Mukuda, Hijiri Kito, Parasharam M. Shirage, R. E. Walstedt, Shiho Iwai, Shin-ichiro Tabata, Sunao Shimizu, Yoshio Kitaoka   +10 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Beyond Democratic Tolerance: Witch Killings in Timor-Leste

Journal of Current Southeast Asian Affairs, 2015
Newly democratising states experience challenges in reconciling “traditional” or “customary” dispute resolution practices with newly established state-based legal systems based on the rule of law. For Timor-Leste, these tensions are pronounced in
Rebecca Strating, Beth Edmondson
doaj  

Kant 300

Magyar Filozófiai Szemle
2024-ben világszerte megemlékeztek Kant születésének 300. évfordulójáról. Annak a sokszínű közösségnek a tagjai, amelyet valaha „az írástudók köztársaságának” neveztek, s amely a kései német felvilágosodás halványuló reményeinek ingatag alapjaként az idősödő Kant számára is oly fontos volt, megszámlálhatatlanul sok konferencián ünnepelték a filozófust –
Ákos Forczek, Tamás Ullmann
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source