Results 11 to 20 of about 617,855 (266)

Morphological and Functional Changes of Rat Hepatocytes by Vertical Cell-Cell Adhesion in Three-Dimensional Stacked-Up Culture

Journal of Biomechanical Science and Engineering, 2008
Vertical cell-cell contact is an important difference between 2D- and 3D-culture models. We hypothesized that this difference in cell-cell contacts is critical in maintaining hepatocyte functions.
Ryo SUDO, Toshihiro MITAKA, Mariko IKEDA, Kazuo TANISHITA   +3 more
doaj   +1 more source

Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids

Biology Open, 2021
Emerging three-dimensional (3D) cultures of glioblastoma are becoming powerful models to study glioblastoma stem cell behavior and the impact of cell–cell and cell–microenvironment interactions on tumor growth and invasion.
Roberta Azzarelli, Michela Ori, Anna Philpott, Benjamin D. Simons   +3 more
doaj   +1 more source

Evaluation Of Protective Effects Of Alginate Hydrogel During Neurons Transdifferentiated From Bone Marrow Stromal Cells On Decrease Of Reactive Oxygene Specious

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: Cell therapy is a feasible method for the treatment of spinal cord injury as well as other neurological disorders. Because of the cell death reported to be in the cell transplants, the use of +scaffolds can be useful to improve cell ...
Leila Salari asl, Taki Tiraihi
doaj  

3D Multicellular Spheroid for the Study of Human Hematopoietic Stem Cells: Synergistic Effect Between Oxygen Levels, Mesenchymal Stromal Cells and Endothelial Cells

Journal of Blood Medicine, 2021
Emilia Barreto-Duran,1 Claudia Camila Mejia-Cruz,1 Luis Fernando Jaramillo-Garcia,2 Efrain Leal-Garcia,3 Alfonso Barreto-Prieto,1 Viviana Marcela Rodriguez-Pardo1 1Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad ...
Barreto-Duran E, Mejia-Cruz CC, Jaramillo-Garcia LF, Leal-Garcia E, Barreto-Prieto A, Rodriguez-Pardo VM   +5 more
doaj  

Reprogramming of spermatogonial stem cells into pluripotent stem cells in the spheroidal state

Animal Cells and Systems, 2019
Spermatogonial stem cells (SSCs) are unipotent adult stem cells, capable of differentiating into sperm cells. SSCs can be cultured in vitro for a long time.
Yukyeong Lee, Minseong Lee, Seung-Won Lee, Na Yong Choi, Seokbeom Ham, Hye Jeong Lee, Kisung Ko, Kinarm Ko   +7 more
doaj   +1 more source

Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay

Marine Drugs, 2019
Plocabulin is a novel microtubule-disrupting antitumor agent of marine origin that is currently undergoing phase II clinical trials. Plocabulin has potent antiproliferative and antiangiogenic actions in carcinoma cell lines and has antitumor activity in ...
Alba Costales-Carrera, Asunción Fernández-Barral, Pilar Bustamante-Madrid, Laura Guerra, Ramón Cantero, Antonio Barbáchano, Alberto Muñoz   +6 more
doaj   +1 more source

Walking-Induced Bone Strain Stimulates Cultured Osteoblasts Accompanied by the Low-Magnitude, High Frequency Components

Journal of Biomechanical Science and Engineering, 2009
The purpose of this study is to test a hypothesis that involvement of the low-magnitude, high frequency strain components in the walking-induced bone strain is essential to elicit the osteogenic response of osteoblasts to the bone strain.
Shigeo M. TANAKA, Hui B. SUN
doaj   +1 more source

Development of a three-dimensional direct current electric field stimulation bioreactor to enhance the axonal outgrowth and control the axonal orientation

Journal of Biomechanical Science and Engineering, 2020
Until now, numerous studies on the effects of electrical stimulation on nerve cell activation in a cell culture have been conducted. However, there are very few studies that have used the three-dimensional (3D) culture system to investigate nerve cell ...
Eiji NAKAMACHI, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA, Manabu OKITA   +4 more
doaj   +1 more source

Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity

Neurobiology of Disease, 2022
Oxidative stress is caused by an imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in brain aging and age-related neurodegenerative diseases.
David Pamies, Daphne Wiersma, Moriah E. Katt, Liang Zhao, Johannes Burtscher, Georgina Harris, Lena Smirnova, Peter C. Searson, Thomas Hartung, Helena T. Hogberg   +9 more
doaj   +1 more source

The Stabilization Effect of Mesenchymal Stem Cells on the Formation of Microvascular Networks in a Microfluidic Device

Journal of Biomechanical Science and Engineering, 2013
There is a demand for three-dimensional (3D) angiogenesis model including endothelial cells (ECs) and mesenchymal stem cells (MSCs), which are known to differentiate into pericytes, to construct stabilized and matured microvascular networks in vitro ...
Kyoko YAMAMOTO, Kohei TANIMURA, Yo MABUCHI, Yumi MATSUZAKI, Seok CHUNG, Roger D. KAMM, Mariko IKEDA, Kazuo TANISHITA, Ryo SUDO   +8 more
doaj   +1 more source