Results 51 to 60 of about 617,855 (266)

PREOPERATIVE PREPARATION OF LIMBAL CELL TRANSPLANTS FOR THE TREATMENT OF OPTIC NEUROPATHY (EXPERIMENTAL STUDY)

Офтальмохирургия, 2017
Purpose. To study experimentally in vitro secretion of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF) using intact and induced multi-potent mesenchymal limbal stem cells (MSCs) in three-dimensional culture (3D).Material ...
S. A. Borzenok, M. K. Khubetsova, I. N. Saburina, N. A. Gavrilova, Y. A. Komakh, K. D. Tonaeva, D. S. Ostrovsky, N. I. Lanevskaya, L. N. Skuratovskaya, V. S. Repin   +9 more
doaj   +1 more source

A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue

Frontiers in Bioengineering and Biotechnology, 2021
Three-dimensional (3D) co-culture models have closer physiological cell composition and behavior than traditional 2D culture. They exhibit pharmacological effects like in vivo responses, and therefore serve as a high-throughput drug screening model to ...
Jietao Lin, Jietao Lin, Jietao Lin, Antonia RuJia Sun, Antonia RuJia Sun, Antonia RuJia Sun, Jian Li, Jian Li, Jian Li, Tianying Yuan, Wenxiang Cheng, Wenxiang Cheng, Wenxiang Cheng, Liqing Ke, Liqing Ke, Liqing Ke, Jianhai Chen, Jianhai Chen, Jianhai Chen, Wei Sun, Shengli Mi, Peng Zhang, Peng Zhang, Peng Zhang   +23 more
doaj   +1 more source

3D culture for cardiac cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
This review discusses historical milestones, recent developments and challenges in the area of 3D culture models with cardiovascular cell types. Expectations in this area have been raised in recent years, but more relevant in vitro research, more accurate drug testing results, reliable disease models and insights leading to bioartificial organs are ...
openaire   +2 more sources

3D PHOTOGRAPHS IN CULTURAL HERITAGE [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013
Abstract. This paper on providing "oo-information" (= objective object-information) on cultural monuments and sites, based on 3D photographs is also a contribution of CIPA task group 3 to the 2013 CIPA Symposium in Strasbourg. To stimulate the interest in 3D photography for scientists as well as for amateurs, 3D-Masterpieces are presented. Exemplary it
W. Schuhr, J. D. Lee, St. Kiel
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Canine endometrial organoids respond to exogenous steroid hormones and are an in vitro model for cystic endometrial hyperplasia

Reproduction and Fertility
The etiology, epidemiology, and pathogenesis of many uterine diseases, including endometritis, cystic endometrial hyperplasia (CEH), and pyometra, remain poorly understood in canids, hindering the advancement of effective preventative therapeutics to ...
Riley E Thompson, Alexandria M Horner, Charissa Ehresman, Ahmed Gad, Mindy A Meyers, Jennifer Palmer, DN Rao Veeramachaneni, Budhan S Pukazhenthi, Fiona K Hollinshead   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase

Stem Cell Research & Therapy, 2020
Background Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes.
Xiaofang Liu, Jinhua Qin, Mingyang Chang, Shuyong Wang, Yali Li, Xuetao Pei, Yunfang Wang   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source