Results 61 to 70 of about 668,339 (308)
Cells, 2020 There is a limited number of established ovarian cancer cell lines matching the low-grade serous histotype available for research purposes. Three-dimensional (3D) culture systems provide in vitro models with better tissue-like characteristics than two ...
Caroline Natânia de Souza-Araújo +6 more
doaj +1 more source
European Journal of Cell Biology, 2022 Mesenchymal stem cells (MSCs) show a decline in pluripotency and differentiation with increased cell culture passages in 2D cultures. The 2D monolayer culture fails to correctly imitate the architecture and microenvironments of in-vivo cell models ...
Gitika Thakur +10 more
doaj +1 more source
Engineered three-dimensional microenvironments as functional in vitro models of stromal tissues [PDF]
, 2014 Currently, the majority of current cultures is still carried out with long-established techniques like the exploitation of 2D supports, the use of tissue-derived immortalized cell lines, and the administration of un-physiological doses of soluble factors
Piccinini, Elia
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Representative secretome from 3D culture or 3D co-cultured spheroids. [PDF]
, 2022 Representative secretome from 3D culture or 3D co-cultured spheroids.
Andreia M. Porcari (5093840) +10 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Microenvironment-Cell Nucleus Relationship in the Context of Oxidative Stress
Frontiers in Cell and Developmental Biology, 2018 The microenvironment is a source of reactive oxygen species (ROS) that influence cell phenotype and tissue homeostasis. The impact of ROS on redox pathways as well as directly on epigenetic mechanisms and the DNA illustrate communication with the cell ...
Shirisha Chittiboyina +5 more
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THE VAST PROJECT: VALORISATION OF HISTORY AND LANDSCAPE FOR PROMOTING THE MEMORY OF WWI [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017 The VAST (valorisation of history and landscape) project (http://vast.fbk.eu/) was part of the initiatives promoted by the Autonomous Province of Trento (Italy) for the commemoration of the 100th Anniversary of the First World War (WWI) outbreak.
E. Nocerino +13 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Cell-Type-Specific Quantification of a Scaffold-Based 3D Liver Co-Culture
Methods and Protocols, 2019 In order to increase the metabolic activity of human hepatocytes and liver cancer cell lines, many approaches have been reported in recent years. The metabolic activity could be increased mainly by cultivating the cells in 3D systems or co-cultures (with
Marc Ruoß +9 more
doaj +1 more source