Results 81 to 90 of about 668,339 (308)

Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture. [PDF]

PLoS ONE, 2018
Mesenchymal stem cells (MSCs) play important roles in tissue regeneration, and multi-lineage differentiation and immunomodulation are two major characteristics of MSCs that are utilized in stem cell therapy.
Jing Li, Tong Chen, Xiahe Huang, Yunshan Zhao, Bin Wang, Yanyun Yin, Yi Cui, Yannan Zhao, Ruiping Zhang, Xiujie Wang, Yingchun Wang, Jianwu Dai   +11 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Perspective in 3D mesenchymal stromal cells as tools for potential diabetes treatment

Research in Pharmaceutical Sciences
Background and purpose: Diabetes represents one of the major global health issues, and the number of cases is expected to increase dramatically in the coming years.
Alessia Dallatana, Linda Cremonesi, Damiano Coato, Giulio Innamorati, Luca Giacomello   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Canine endometrial organoids respond to exogenous steroid hormones and are an in vitro model for cystic endometrial hyperplasia

Reproduction and Fertility
The etiology, epidemiology, and pathogenesis of many uterine diseases, including endometritis, cystic endometrial hyperplasia (CEH), and pyometra, remain poorly understood in canids, hindering the advancement of effective preventative therapeutics to ...
Riley E Thompson, Alexandria M Horner, Charissa Ehresman, Ahmed Gad, Mindy A Meyers, Jennifer Palmer, DN Rao Veeramachaneni, Budhan S Pukazhenthi, Fiona K Hollinshead   +8 more
doaj   +1 more source

PREOPERATIVE PREPARATION OF LIMBAL CELL TRANSPLANTS FOR THE TREATMENT OF OPTIC NEUROPATHY (EXPERIMENTAL STUDY)

Офтальмохирургия, 2017
Purpose. To study experimentally in vitro secretion of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF) using intact and induced multi-potent mesenchymal limbal stem cells (MSCs) in three-dimensional culture (3D).Material ...
S. A. Borzenok, M. K. Khubetsova, I. N. Saburina, N. A. Gavrilova, Y. A. Komakh, K. D. Tonaeva, D. S. Ostrovsky, N. I. Lanevskaya, L. N. Skuratovskaya, V. S. Repin   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

3D-printable Zwitterionic Nano-composite Hydrogel System for Biomedical Applications [PDF]

, 2019
Data to used in 3D-printable Zwitterionic Nano-composite Hydrogel System for Biomedical Applications paper.This include:Viscosity data for SPE hydrogel of different compositions as well as at different time points after preparation.Tensile data of 3D ...
Simon Martin (1249167), Mark Lewis (1255254), Andrew Capel (1258833), Daniel Engstrom (1253022), Nathalie Sallstrom (1259853)   +4 more
core   +1 more source