Results 81 to 90 of about 1,015,150 (276)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A comprehensive taxonomy for three-dimensional displays [PDF]

, 2012
Even though three-dimensional (3D) displays have been introduced in relatively recent times in the context of display technology, they have undergone a rapid evolution, to the point that a plethora of equipment able to reproduce dynamic three-dimensional
Pimenta, Waldir, Santos, Luís Paulo
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dynamic 3D Network Data Visualization [PDF]

, 2018
Monitoring network traffic has always been an arduous and tedious task because of the complexity and sheer volume of network data that is being consistently generated.
Stafford, Brok
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Scaling of Three-Dimensional Computer-Generated Holograms with Layer-Based Shifted Fresnel Diffraction

Applied Sciences, 2019
Holographic three-dimensional (3D) displays can reconstruct a whole wavefront of a 3D scene and provide rich depth information for the human eyes. Computer-generated holographic techniques offer an efficient way for reconstructing holograms without ...
Hao Zhang, Liangcai Cao, Guofan Jin
doaj   +1 more source

3D audio as an information-environment: manipulating perceptual significance for differntiation and pre-selection [PDF]

, 2001
Contemporary use of sound as artificial information display is rudimentary, with little 'depth of significance' to facilitate users' selective attention. We believe that this is due to conceptual neglect of 'context' or perceptual background information.
Lennox, Peter, Myatt, Tony, Vaughan, John   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Recent Advances and Applications of Holographic 3D Display

Research
Due to the importance of vision in human lives, 3-dimensional (3D) display has become a key and hot topic in the field of information research. With the advancement of computer science technology, holographic 3D display, capable of fully recording and ...
Qian Huang, Rui-Yi Zhao, Chen-Liang Chang, Yi-Wei Zheng, Yi-Long Li, Zhao-Song Li, Nan-Nan Li, Chao Liu, Da-Wei Zhang, Song-Lin Zhuang, Di Wang   +10 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source