Results 271 to 280 of about 2,629,967 (312)

The 3D genome of plasma cells in multiple myeloma. [PDF]

open access: yesSci Rep
Zhang K   +11 more
europepmc   +1 more source

Structural Variation and 3D Genome-Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication. [PDF]

open access: yesAdv Sci (Weinh)
Shao L   +11 more
europepmc   +1 more source

The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse models

open access: yes
Kashuk E   +8 more
europepmc   +1 more source
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3D or Not 3D: Shaping the Genome during Development

Cold Spring Harbor Perspectives in Biology, 2021
One of the most fundamental questions in developmental biology is how one fertilized cell can give rise to a fully mature organism and how gene regulation governs this process. Precise spatiotemporal gene expression is required for development and is believed to be achieved through a complex interplay of sequence-specific information, epigenetic ...
Glaser, J. ; https://orcid.org/0000-0001-6745-6924   +1 more
openaire   +4 more sources

3D Genomics

Molecular Biology, 2019
The development of new research methods significantly changed our views on the role that the 3D organization of the genome plays in its functional activity. It was found that the genome is subdivided into structural-functional units that restrict the area of enhancer action at the level of spatial organization.
S V, Razin, S V, Ulianov, A A, Gavrilov
openaire   +2 more sources

Organization and function of the 3D genome

Nature Reviews Genetics, 2016
Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and how it can be established, reset ...
Bonev, B, Cavalli, Giacomo
openaire   +3 more sources

Mechanical forces and the 3D genome

Current Opinion in Structural Biology, 2023
Traditionally, the field of genomics has been studied from a biochemical perspective. Besides chemical influences, cells are subject to a variety of mechanical signals from their surrounding tissue microenvironment. These mechanical signals can not only cause changes to a cell's physical structure but can also lead to alterations in their genomes and ...
openaire   +3 more sources

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