Results 281 to 290 of about 2,629,967 (312)
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Expanding the toolbox for 3D genomics
Nature Genetics, 2018The ability to visualize and study the 3D folding of chromosomes in cells has been propelled forward by several major technological advances in the past two decades. Two new studies now further expand the scientific toolbox for studying chromosome conformation by providing novel methodologies for accurate mapping of genome topology and predicting the ...
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Chinese Science Bulletin, 2014
It is already more than 10 years after the completion of Human Genome Project. However, the mechanism about how genomic information guides the gene expression in a particular space and time remains to be elucidated. Structure determines function is a consensus that we understand the laws of nature.
ShengMing DU +3 more
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It is already more than 10 years after the completion of Human Genome Project. However, the mechanism about how genomic information guides the gene expression in a particular space and time remains to be elucidated. Structure determines function is a consensus that we understand the laws of nature.
ShengMing DU +3 more
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Advances in technologies for 3D genomics research
Science China Life Sciences, 2020The spatial structure of the orderly organized chromatin in the nucleus has important roles in maintaining normal cell function and in regulation of gene expression, and the high-throughput Hi-C and ChIA-PET methods have been widely used in various biological studies for determining potential spatial genome structures and their functions.
Yan, Zhang, Guoliang, Li
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A tour of 3D genome with a focus on CTCF
Seminars in Cell & Developmental Biology, 2019The complex three-dimensional (3D) structure of the genome plays critical roles in the maintenance of genome stability, organization, and dynamics and in regulation of gene expression for understanding molecular mechanisms and diseases. Chromatin maintains biological functions and transcriptional activities through long distance interaction and ...
Diane C, Wang +3 more
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3D genome and its disorganization in diseases
Cell Biology and Toxicology, 2018The chromosomes in eukaryotic cells are highly folded and organized to form dynamic three-dimensional (3D) structures. In recent years, many technologies including chromosome conformation capture (3C) and 3C-based technologies (Hi-C, ChIA-PET) have been developed to investigate the 3D structure of chromosomes.
Ruifeng, Li +5 more
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Nature Methods, 2009
Refinements in methods to uncover the higher-order structure of the genome will allow functional insight into genomic architecture at high resolution.
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Refinements in methods to uncover the higher-order structure of the genome will allow functional insight into genomic architecture at high resolution.
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An uneven race: genome editing for parasitic worms
Nature Reviews Microbiology, 2021Geetha Sankaranarayanan +2 more
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MicroRNAome genome: A treasure for cancer diagnosis and therapy
Ca-A Cancer Journal for Clinicians, 2014Ioana Berindan Neagoe +2 more
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