Results 251 to 260 of about 4,889,916 (279)

Unraveling the three-dimensional (3D) genome architecture in Neurodevelopmental Disorders (NDDs)

Neurogenetics
The human genome, comprising millions of pairs of bases, serves as the blueprint of life, encoding instructions for cellular processes. However, genomes are not merely linear sequences; rather, the complex of DNA and histones, known as chromatin, exhibits complex organization across various levels, which profoundly influence gene expression and ...
P, Carballo-Pacoret, A, Carracedo, C, Rodriguez-Fontenla   +2 more
openaire   +2 more sources

Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics

Genes & Development
The three-dimensional (3D) genome provides an essential layer of organization that shapes genome function in space and time. Chromatin compartments and topologically associating domains (TADs) arise from the interplay between intrinsic properties of chromatin and architectural factors, including cohesin and CTCF.
Rebecca G. Smith, Hannah M. Wilson, Kathleen L. Schiela, Yu Liu   +3 more
openaire   +2 more sources

Two Gap-Free Reference Genomes and a Global View of the Centromere Architecture in Rice

Molecular Plant, 2021
Evan Long, Daojun Yuan, Rod A. Wing
exaly  

The Self-Organizing Genome: Principles of Genome Architecture and Function

Cell, 2020
Tom Misteli
exaly  

Comparative Genome Analyses Highlight Transposon-Mediated Genome Expansion and the Evolutionary Architecture of 3D Genomic Folding in Cotton

Molecular Biology and Evolution, 2021
Maojun Wang, Fang Liu, Xianlong Zhang
exaly  

3D genome architecture — of loops and globules

Nature Reviews Genetics, 2014
openaire   +1 more source

3D Genome Architecture of Human Renal Cortex and Medulla

Journal of the American Society of Nephrology, 2020
Selvaraj Muthusamy, Shreeram Akilesh
openaire   +1 more source

Translating Cancer Genomes and Transcriptomes for Precision Oncology

Ca-A Cancer Journal for Clinicians, 2016
Sunita Shankar, Sameek Roychowdhury
exaly  

Reconstructing 3D genome architecture using SHAKER

Presentamos SHAKER, un marco computacional para la reconstrucción de la arquitectura 3D de la cromatina, que integra datos de contacto Hi-C con imágenes de superresolución obtenidas mediante OligoSTORM. SHAKER construye la cromatina como una cadena de polímeros, definida por frecuencias de interacción y densidades espaciales, optimizadas a través de un
openaire   +1 more source

Evolution and Genome Architecture in Fungal Plant Pathogens

Nature Reviews Microbiology, 2017
Eva H Stukenbrock, Mareike Möller
exaly