Results 1 to 10 of about 138,031 (115)
The Fluid Mosaic Model of chromatin organization: integrating dynamics, conformational heterogeneity and multiscale organization [PDF]
Communications BiologyThe field of 3D chromatin organization has advanced significantly in recent years, with a marked increase in research focusing on dynamics and viscoelastic properties of chromatin.
Ajazul H. Wani
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MeCP2-driven chromatin organization controls nuclear stiffness [PDF]
Communications BiologyCellular differentiation is driven by epigenetic modifiers and readers, including the methyl CpG binding protein 2 (MeCP2), whose level and mutations cause the neurological disorder Rett syndrome.
Hector Romero +13 more
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Transposable elements that have recently been mobile in the human genome
BMC Genomics, 2021 Background Transposable elements (TE) comprise nearly half of the human genome and their insertions have profound effects to human genetic diversification and as well as disease.
Matias I. Autio +5 more
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Frontiers in Immunology, 2020 Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized.
Llorenç Rovirosa +3 more
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Cell Regeneration, 2022 Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating gene expression.
Xiaoru Ling +4 more
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Regulation of chromatin organization during animal regeneration
Cell Regeneration, 2023 Activation of regeneration upon tissue damages requires the activation of many developmental genes responsible for cell proliferation, migration, differentiation, and tissue patterning.
Xiaohui Jia, Weifeng Lin, Wei Wang
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How enzymatic activity is involved in chromatin organization
eLife, 2022 Spatial organization of chromatin plays a critical role in genome regulation. Previously, various types of affinity mediators and enzymes have been attributed to regulate spatial organization of chromatin from a thermodynamics perspective.
Rakesh Das +4 more
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Evaluation of chromatin mesoscale organization
APL Bioengineering, 2022 Chromatin organization in the nucleus represents an important aspect of transcription regulation. Most of the studies so far focused on the chromatin structure in cultured cells or in fixed tissue preparations. Here, we discuss the various approaches for
Dana Lorber, Talila Volk
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Regulation of chromatin microphase separation by binding of protein complexes
eLife, 2023 We show evidence of the association of RNA polymerase II (RNAP) with chromatin in a core-shell organization, reminiscent of microphase separation where the cores comprise dense chromatin and the shell, RNAP and chromatin with low density.
Omar Adame-Arana +4 more
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Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation. [PDF]
PLoS ONE, 2013 Unlike other tissues, development and differentiation of the mammary gland occur mostly after birth. The roles of systemic hormones and local growth factors important for this development and functional differentiation are well-studied. In other tissues,
Monique Rijnkels +6 more
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