Results 31 to 40 of about 3,249,481 (296)

Proteomic interrogation of human chromatin. [PDF]

, 2011
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary, Christodoulos A Floudas, Floudas, Christodoulos A., Barry M Zee, Garcia, Benjamin A., Richard C Baliban, Baliban, Richard C., Sandra B Hake, Torrente, Mariana P., Zee, Barry M., Hake, Sandra B., Christodoulos A. Floudas, Barry M. Zee, Nicolas L. Young, Mariana P. Torrente, Gary LeRoy, Richard C. Baliban, Sandra B. Hake, Benjamin A. Garcia, Nicolas L Young, Benjamin A Garcia, Young, Nicolas L., Mariana P Torrente, Torrente Mariana P., Zee Barry M., Young Nicolas L., Hake Sandra B., LeRoy Gary, Garcia Benjamin A., Floudas Christodoulos A., Baliban Richard C.   +30 more
core   +2 more sources

Understanding three-dimensional chromatin organization in diploid genomes

Computational and Structural Biotechnology Journal, 2021
The three-dimensional (3D) organization of chromatin in the nucleus of diploid eukaryotic organisms has fascinated biologists for many years. Despite major progress in chromatin conformation studies, current knowledge regarding the spatial organization ...
Jing Li, Yu Lin, Qianzi Tang, Mingzhou Li   +3 more
doaj   +1 more source

Chromatin organization in myelodysplastic syndrome. [PDF]

Exp Hematol
Disordered chromatin organization has emerged as a new aspect of the pathogenesis of myelodysplastic syndrome (MDS). Characterized by lineage dysplasia and a high transformation rate to acute myeloid leukemia (AML), the genetic determinant of MDS is thought to be the main driver of the disease's progression.
Xu JJ, Viny AD.
europepmc   +3 more sources

Bridging the dynamics and organization of chromatin domains by mathematical modeling

Nucleus, 2017
The genome is 3-dimensionally organized in the cell, and the mammalian genome DNA is partitioned into submegabase-sized chromatin domains. Genome functions are regulated within and across the domains according to their organization, whereas the chromatin
Soya Shinkai, Tadasu Nozaki, Kazuhiro Maeshima, Yuichi Togashi   +3 more
doaj   +1 more source

Chromatin Organization [PDF]

Cell, 2011
Although the Victorian proverb “everything in its place and a place for everything” is meant for orderly households, it could just as easily describe the organization of eukaryotic genomes. This issue's Select profiles articles that reveal new insights into how DNA is packaged and partitioned into three-dimensional (3D) structures throughout the life ...
openaire   +1 more source

Non-specific interactions are sufficient to explain the position of heterochromatic chromocenters and nucleoli in interphase nuclei [PDF]

, 2009
The organization of the eukaryote nucleus into functional compartments arises by self-organization both through specific protein–protein and protein–DNA interactions and non-specific interactions that lead to entropic effects, such as e.g.
Nooijer, S., de, Bisseling, T., Wellink, J., Mulder, B.   +3 more
core   +1 more source

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco, Prisco, Antonella, Nicodemi, Mario, Nicodemi M, Prisco A   +4 more
core   +1 more source

Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA [PDF]

, 2010
Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core   +1 more source

ATAC-See : A Tn5 Transposase-Mediated Assay for Detection of Chromatin Accessibility with Imaging

, 2023
Assay of transposase-accessible chromatin with visualization (ATAC-see), a transposase-mediated imaging technology that enables direct imaging of the accessible genome in situ and deep sequencing to reveal the identity of the imaged elements.
Yadav, Ram Prakash,, Dang, Yonglong,, Chen, Xingqi,   +2 more
core   +1 more source

Chromatin organization and transcriptional regulation [PDF]

Current Opinion in Genetics & Development, 2013
Cell type specific transcriptional regulation must be adhered to in order to maintain cell identity throughout the lifetime of an organism, yet it must be flexible enough to allow for responses to endogenous and exogenous stimuli. This regulation is mediated not only by molecular factors (e.g.
Michael R, Hübner, Mélanie A, Eckersley-Maslin, David L, Spector   +2 more
openaire   +2 more sources